R. Hal Scofield
YOU?
Author Swipe
View article: Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease
Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease Open
Objectives Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and…
View article: Broadened autoantibody profiling in incomplete lupus erythematosus 2448
Broadened autoantibody profiling in incomplete lupus erythematosus 2448 Open
Description Incomplete lupus erythematosus (ILE) is characterized by clinical and/or serological features suggestive of systemic lupus erythematosus (SLE) but insufficient for disease classification. While some ILE patients progress to SLE…
View article: Interrogation of Million Veteran Program data reveals associations between post-traumatic stress disorder and autoimmune and other immune-mediated inflammatory diseases 3945
Interrogation of Million Veteran Program data reveals associations between post-traumatic stress disorder and autoimmune and other immune-mediated inflammatory diseases 3945 Open
Description Post-traumatic stress disorder (PTSD), a psychiatric condition caused by exposure to a highly traumatic event, is characterized by intrusive thoughts, negative cognitions, and hyperarousal. While often considered purely psychol…
View article: Dietary Strawberries Improve Serum Antioxidant Profiles in Adults with Prediabetes: A 28-Week Randomized Controlled Crossover Trial
Dietary Strawberries Improve Serum Antioxidant Profiles in Adults with Prediabetes: A 28-Week Randomized Controlled Crossover Trial Open
Prediabetes increases oxidative stress and the risk of type 2 diabetes and related cardiovascular diseases. Previous trials have shown antioxidant-rich strawberries improve this risk, but effects on antioxidant markers are inconclusive. Th…
View article: Evaluating Anti-CCL25 as a Therapeutic Strategy to Disrupt Foci Formation in a Spontaneous Murine Model of Sjögren’s Disease
Evaluating Anti-CCL25 as a Therapeutic Strategy to Disrupt Foci Formation in a Spontaneous Murine Model of Sjögren’s Disease Open
Sjögren’s disease (SjD) targets the salivary and lacrimal glands and is characterized by autoantibody production and glandular lymphocytic infiltrate with ectopic germinal centers (EGCs). The chemokine CCL25 recruits CCR9+ CD4+ T cells to …
View article: Evaluating Anti-CCL25 as a Therapeutic Strategy to Disrupt Foci Formation in a Spontaneous Murine Model of Sjögren’s Disease
Evaluating Anti-CCL25 as a Therapeutic Strategy to Disrupt Foci Formation in a Spontaneous Murine Model of Sjögren’s Disease Open
Background: Sjögren’s disease (SjD) targets the salivary and lacrimal glands and is characterized by autoantibody production and glandular lymphocytic infiltrate with ectopic germinal centers (EGCs). The chemokine CCL25 recruits CCR9⁺ CD4⁺…
View article: Amytrapper Catheter: A Prototype Extracorporeal Device That Traps Blood Amyloid-β in a Rat Model of Alzheimer’s Disease
Amytrapper Catheter: A Prototype Extracorporeal Device That Traps Blood Amyloid-β in a Rat Model of Alzheimer’s Disease Open
Alzheimer’s disease (AD) presents a pressing global health challenge, with amyloid-β (Aβ) accumulation in the brain being a hallmark feature. While monoclonal antibodies targeting Aβ have shown cognitive benefits, safety concerns remain. H…
View article: Rheumatic autoimmune disease in relation to post-traumatic stress disease and traumatic brain injury
Rheumatic autoimmune disease in relation to post-traumatic stress disease and traumatic brain injury Open
Background Post traumatic stress disorder (PTSD) is associated with traumatic brain injury (TBI) and autoimmune disease, including systemic lupus erythematosus (SLE). We sought to determine whether the association was related to only PTSD …
View article: Mitochondrial dysfunction and fatigue in Sjögren’s disease
Mitochondrial dysfunction and fatigue in Sjögren’s disease Open
Objective Sjögren’s disease (SjD) is a chronic exocrine disorder typified by inflammation and dryness, but also profound fatigue, suggesting a pathological basis in cellular bioenergetics. In healthy states, dysfunctional mitochondria are …
View article: Experimental induction of anti-muscarinic type-3-receptor extracellular loop antibodies by immunization with 4-hydroxy-2-nonenal modified Ro60 and unmodified Ro60
Experimental induction of anti-muscarinic type-3-receptor extracellular loop antibodies by immunization with 4-hydroxy-2-nonenal modified Ro60 and unmodified Ro60 Open
Objective Sjögren’s Disease (SjD) subjects have decreased lacrimal/salivary gland function. Studies have proposed that autoantibodies targeting G-protein-coupled muscarinic acetylcholine-type-3-receptor (M3R) are potential clinical markers…
View article: Recommendations for Aligned Nomenclature of Peripheral Nervous System Disorders Across Rheumatology and Neurology
Recommendations for Aligned Nomenclature of Peripheral Nervous System Disorders Across Rheumatology and Neurology Open
[Image: see text]
View article: Mitochondrial Dysfunction and Fatigue in Sjögren’s Disease
Mitochondrial Dysfunction and Fatigue in Sjögren’s Disease Open
Objectives Sjögren’s disease (SjD) is a common exocrine disorder typified by chronic inflammation and dryness, but also profound fatigue, suggesting a pathological basis in cellular bioenergetics. In healthy states, damaged or dysfunctiona…
View article: 703 Pervasive sharing of causal genetic risk factors contributes to clinical and molecular overlap between Sjögren’s Disease and SLE
703 Pervasive sharing of causal genetic risk factors contributes to clinical and molecular overlap between Sjögren’s Disease and SLE Open
Background/Purpose SLE (Systemic Lupus Erythematosus) and SjD (Sjögren's Disease) are similar diseases. Patients with these conditions share many overlapping features and some patients meet the classification criteria for both disease stat…
View article: 702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP)
702 Comparative genome wide association studies (GWASs) of systemic lupus erythematosus (SLE) and multiple sclerosis (MS) from the million veteran program (MVP) Open
Background Strong evidence supports Epstein-Barr virus (EBV) being an original cause for most cases of both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). The Million Veteran Program (MVP) data reduces artifacts from techn…
View article: 701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE)
701 A million veteran program (MVP) genome-wide association study (GWAS) of systemic and cutaneous lupus erythematosus (SLE & CLE) Open
Background >36,000 Veterans have been diagnosed with systemic lupus erythematosus (SLE). With the SLE and cutaneous lupus (CLE) cases and unaffected controls in MVP, we performed a genome-wide association study (GWAS). Methods Cases with t…
View article: P51 First case of lupus: Bishop Eraclius of Liège, Belgium
P51 First case of lupus: Bishop Eraclius of Liège, Belgium Open
Background Around 963 A.D., Bishop Eraclius (Liège, Belgium) wrote an affidavit stating, 'I … was nearly taken to death by the disease called Lupus.' On the seventh night of praying at Saint Martin's tomb (Tours, France), Saints Martin and…
View article: The Potential Utility of Salivary and Tear Proteomics to Discriminate Sjögren’s Disease from Non-Sjögren’s Sicca
The Potential Utility of Salivary and Tear Proteomics to Discriminate Sjögren’s Disease from Non-Sjögren’s Sicca Open
Sjögren’s Disease (SjD) is an autoimmune disorder associated with decreased saliva and/or tear secretions, resulting in patients reporting dryness in the mouth and eyes. Serum autoantibodies directed against the Ro60/SS-A and La/SS-B autoa…
View article: Variants in the<i>DDX6-CXCR5</i>autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Variants in the<i>DDX6-CXCR5</i>autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland Open
Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren’s Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57…
View article: Increased carotid intima–media thickening and antioxidized low-density lipoprotein in an anti-Ro60 SLE autoantibody subset
Increased carotid intima–media thickening and antioxidized low-density lipoprotein in an anti-Ro60 SLE autoantibody subset Open
Objective Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). We have previously shown an association of anti-Ro60/La/Ro52 with antioxidized low-density lipoprotein (LDL) in SLE. Here, we hypothesized that caro…
View article: Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus
Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren’s Disease and Systemic Lupus Erythematosus Open
SjD (Sjögren’s Disease) and SLE (Systemic Lupus Erythematosus) are similar diseases. There is extensive overlap between the two in terms of both clinical features and pathobiologic mechanisms. Shared genetic risk is a potential explanation…
View article: Perspective: Developing Future Veterans Affairs Scientists Through a Diversity, Equity, and Inclusion Program
Perspective: Developing Future Veterans Affairs Scientists Through a Diversity, Equity, and Inclusion Program Open
For >95 years, the Department of Veterans Affairs Office of Research and Development (ORD) has been improving the lives of Veterans and all Americans through health care discovery and innovation. Scientists and trainees from diverse backgr…
View article: Impact of race and ethnicity on family participation in systemic lupus erythematosus genetic studies
Impact of race and ethnicity on family participation in systemic lupus erythematosus genetic studies Open
Objective Systemic lupus erythematosus (SLE) has a higher prevalence and is more severe in African Americans and Hispanics than in non-Hispanic Whites. To understand the shared and unique genetic risk factors of these populations, an adequ…
View article: Increased atherosclerotic plaque and anti-oxidized low density lipoprotein in anti-Ro60 SLE autoantibody subset
Increased atherosclerotic plaque and anti-oxidized low density lipoprotein in anti-Ro60 SLE autoantibody subset Open
Objective Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). We previously showed an association of anti-Ro60/La/Ro52 to anti-oxidized LDL in SLE. Here, we hypothesized that atherosclerotic plaque will be asso…