Hala Abou Assi
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View article: Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase
Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase Open
Telomeric C-rich repeated DNA sequences fold into tetrahelical i-motif structures in vitro at acidic pH. While studies have suggested that i-motifs may form in cells, little is known about their potential role in human telomere biology. In…
View article: Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting
Measuring thermodynamic preferences to form non-native conformations in nucleic acids using ultraviolet melting Open
Thermodynamic preferences to form non-native conformations are crucial for understanding how nucleic acids fold and function. However, they are difficult to measure experimentally because this requires accurately determining the population…
View article: delta-Melt: Nucleic acid conformational penalties from melting experiments
delta-Melt: Nucleic acid conformational penalties from melting experiments Open
Thermodynamic propensities of biomolecules to adopt non-native conformations are crucial for understanding how they function, but prove difficult to measure experimentally. Combining optical melting experiments with chemical modifications …
View article: Measuring thermodynamic preferences to form non-native conformations in nucleic acids using melting experiments reveals a rich sequence-specific DNA conformational landscape
Measuring thermodynamic preferences to form non-native conformations in nucleic acids using melting experiments reveals a rich sequence-specific DNA conformational landscape Open
Thermodynamic preferences to form non-native conformations are crucial for understanding how nucleic acids fold and function. However, they are difficult to measure experimentally because this requires accurately determining the population…
View article: Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction
Rapid and accurate determination of atomistic RNA dynamic ensemble models using NMR and structure prediction Open
Biomolecules form dynamic ensembles of many inter-converting conformations which are key for understanding how they fold and function. However, determining ensembles is challenging because the information required to specify atomic structu…
View article: 2′-<i>O</i>-Methylation can increase the abundance and lifetime of alternative RNA conformational states
2′-<i>O</i>-Methylation can increase the abundance and lifetime of alternative RNA conformational states Open
2′-O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays important biological roles through mechanisms that are not entirely understood. There is evidence that Nm can alter the biological activities of RNAs by…
View article: A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Open
Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we have previously demonstrated that parallel-stranded c…
View article: 2’-<i>O</i>-methylation alters the RNA secondary structural ensemble
2’-<i>O</i>-methylation alters the RNA secondary structural ensemble Open
2’- O -methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays important biological roles through mechanisms that are not entirely understood. There is evidence that Nm can alter the biological activities of RNAs …
View article: An RNA dynamic ensemble at atomic resolution
An RNA dynamic ensemble at atomic resolution Open
Biomolecules do not fold into a single 3D structure but rather form dynamic ensembles of many inter-converting conformations 1 . Knowledge of dynamic ensembles is key for understanding how biomolecules fold and function, and for rationally…
View article: A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution
A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Open
Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we have previously demonstrated that parallel-stranded c…
View article: i-Motif DNA: structural features and significance to cell biology
i-Motif DNA: structural features and significance to cell biology Open
The i-motif represents a paradigmatic example of the wide structural versatility of nucleic acids. In remarkable contrast to duplex DNA, i-motifs are four-stranded DNA structures held together by hemi- protonated and intercalated cytosine …
View article: Controlled growth of high-density nanoparticles on zinc oxide thin films by photo-deposition
Controlled growth of high-density nanoparticles on zinc oxide thin films by photo-deposition Open
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View article: Controlled Growth and Grafting of High-Density Au Nanoparticles on Zinc Oxide Thin Films by Photo-Deposition
Controlled Growth and Grafting of High-Density Au Nanoparticles on Zinc Oxide Thin Films by Photo-Deposition Open
The integration of high-purity nano-objects on substrates remains a great challenge for addressing scaling-up issues in nanotechnology. For instance, grafting gold nanoparticles (NPs) on zinc oxide films, a major step process for catalysis…
View article: 2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA
2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA Open
Human telomeres and promoter regions of genes fulfill a significant role in cellular aging and cancer. These regions comprise of guanine and cytosine-rich repeats, which under certain conditions can fold into G-quadruplex (G4) and i-motif …
View article: Mapping the affinity landscape of Thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-Quadruplex microarrays
Mapping the affinity landscape of Thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-Quadruplex microarrays Open
In situ fabricated nucleic acids microarrays are versatile and very high-throughput platforms for aptamer optimization and discovery, but the chemical space that can be probed against a given target has largely been confined to DNA, while …
View article: Stabilization of i-motif structures by 2′-β-fluorination of DNA
Stabilization of i-motif structures by 2′-β-fluorination of DNA Open
i-Motifs are four-stranded DNA structures consisting of two parallel DNA duplexes held together by hemi-protonated and intercalated cytosine base pairs (C:CH(+)). They have attracted considerable research interest for their potential role …
View article: CCDC 1473005: Experimental Crystal Structure Determination
CCDC 1473005: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …