Hala E. Abdel‐Hamied
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View article: Clinico-Pathological Features and Immunohistochemical Comparison of p16, p53, and Ki-67 Expression in Muscle-Invasive and Non-Muscle-Invasive Conventional Urothelial Bladder Carcinoma
Clinico-Pathological Features and Immunohistochemical Comparison of p16, p53, and Ki-67 Expression in Muscle-Invasive and Non-Muscle-Invasive Conventional Urothelial Bladder Carcinoma Open
Introduction: The identification of bladder detrusor muscle invasion in urothelial cancer is essential for prognosis and management. We studied the clinical, histological, and immunohistochemical expression of p16, p53, and Ki-67 in urothe…
View article: A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment
A bioinformatic analysis of the role of TP53 status on the infiltration of CD8+ T cells into the tumor microenvironment Open
CD8+ T cells play basic roles in the immune system in a tumor microenvironment (TME) to fight cancer. Several reports have suggested signs of the involvement of tumor protein p53 (TP53) in a complex immune system network. Moreover, our pre…
View article: ESTROGEN ATTENUATES DIMETHYLHYDRAZINE-INDUCED COLON INJURY IN FEMALE RATS VIA ABROGATION OF OXIDATIVE STRESS AND INFLAMMATIONS
ESTROGEN ATTENUATES DIMETHYLHYDRAZINE-INDUCED COLON INJURY IN FEMALE RATS VIA ABROGATION OF OXIDATIVE STRESS AND INFLAMMATIONS Open
The involvement of estrogen, the female sex hormone, in a variety of gastrointestinal conditions has been documented.We studied the effect of endogenous and exogenous estrogen (estradiol benzoate, 30μg/kg/day S.C) for 8 weeks on early pren…
View article: Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT166 as a Surrogate Model Colorectal Carcinoma
Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT166 as a Surrogate Model Colorectal Carcinoma Open
The IQGAP1 regulates the expression of IQGAPs, Ras, IL-8 receptors, and the apoptotic network. Therefore, the silence of IQGAP1 is a promising strategy for colon cancer therapy.
View article: Stromal immunohistochemistry of the smooth muscle actin expression in indolent versus aggressive basal cell carcinoma
Stromal immunohistochemistry of the smooth muscle actin expression in indolent versus aggressive basal cell carcinoma Open
Background Basal cell carcinoma (BCC) is often locally aggressive but rarely metastasizes. Detection of aggressive BCCs at an early stage is mandatory to avoid localized destruction, which causes disabilities to patients; several factors a…
View article: THERAPEUTIC AND IMMUNO-MODULATORY EFFECT OF SILVER NANOPARTICLES-LOADED WITH METRONIDAZOLE ON EXPERIMENTAL BLASTOCYSTOSIS
THERAPEUTIC AND IMMUNO-MODULATORY EFFECT OF SILVER NANOPARTICLES-LOADED WITH METRONIDAZOLE ON EXPERIMENTAL BLASTOCYSTOSIS Open
Blastocystis is one of the commonest enteric protozoa in many hosts.This study evaluated the effect of silver nanoparticles (AgNps) loaded with metronidazole (MTZ) on mice infected with Blastocystis.They were subjected to parasitological, …
View article: Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression.
Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression. Open
IQGAPs genes play critical role in either induction or suppression of cancer and its progression, however the relationship between Ras genes and these genes are still unclear. In this study, we tried to understand the mechanistic action of…