Haleh Hamedifar
YOU?
Author Swipe
View article: Enzymatic, cell-based, and <i>in silico</i> evaluation of di-substituted aminomethyl-1,2,3-triazole–cinamamide hybrids as mushroom tyrosinase inhibitors
Enzymatic, cell-based, and <i>in silico</i> evaluation of di-substituted aminomethyl-1,2,3-triazole–cinamamide hybrids as mushroom tyrosinase inhibitors Open
A series of novel aryl-substituted aminomethyl 1,2,3-triazole–cinamamide hybrids (9a–q) were synthesized and tested as tyrosinase inhibitors using enzymatic, in silico , and cell-based assays.
View article: Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer’s Disease
Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer’s Disease Open
An Isoindolinedione-benzamide pyridinium derivatives were designed through a structure-based strategy and synthesized as novel multifunctional anti-Alzheimer agents. The inhibitory activities of all 17 derivatives against acetylcholinester…
View article: Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study
Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study Open
In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a novel series of isoindolin-1,3-dione-based acetohydrazides (compounds 8a – h ) was designed, synthesized, and evaluated as possible ac…
View article: Cost-effectiveness and budget impact analysis of Daratumumab, Lenalidomide and dexamethasone for relapsed-refractory multiple myeloma
Cost-effectiveness and budget impact analysis of Daratumumab, Lenalidomide and dexamethasone for relapsed-refractory multiple myeloma Open
Background The prominent efficacy in terms of increasing progression-free survival (PFS) of Daratumumab, Lenalidomide and dexamethasone (DRd) triplet therapy versus Carfilzomib, Lenalidomide and dexamethasone (KRd) was proven previously in…
View article: Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies
Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies Open
View article: Multiple myeloma and the potential of new checkpoint inhibitors for immunotherapy
Multiple myeloma and the potential of new checkpoint inhibitors for immunotherapy Open
Multiple myeloma (MM), a cancer of the bone marrow, is categorized as the second most common hematological malignancy of adults in the Western world. Despite dramatic improvements in immunotherapies in the field of cancers, MM immunotherap…
View article: Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides
Design, synthesis, and cytotoxic evaluation of quinazoline derivatives bearing triazole-acetamides Open
A novel series of quinazoline-based agents bearing triazole-acetamides 8a-l were designed and synthesized. All the obtained compounds were tested for in vitro cytotoxic activities against three human cancer cell lines named H…
View article: Immune checkpoints and cancer immunotherapies: insights into newly potential receptors and ligands
Immune checkpoints and cancer immunotherapies: insights into newly potential receptors and ligands Open
Checkpoint markers and immune checkpoint inhibitors have been increasingly identified and developed as potential immunotherapeutic targets in various human cancers. Despite valuable efforts to discover novel immune checkpoints and their li…
View article: Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors
Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors Open
View article: Design, synthesis, in vitro α-glucosidase inhibition, docking, and molecular dynamics of new phthalimide-benzenesulfonamide hybrids for targeting type 2 diabetes
Design, synthesis, in vitro α-glucosidase inhibition, docking, and molecular dynamics of new phthalimide-benzenesulfonamide hybrids for targeting type 2 diabetes Open
View article: Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors
Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors Open
View article: Author response for "Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review"
Author response for "Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review" Open
View article: Author response for "Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review"
Author response for "Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review" Open
View article: Coronavirus disease 2019 (COVID‐19): An overview of the immunopathology, serological diagnosis and management
Coronavirus disease 2019 (COVID‐19): An overview of the immunopathology, serological diagnosis and management Open
SARS‐CoV‐2 is a novel human coronavirus responsible for the Coronavirus disease 2019 (COVID‐19) pandemic. Pneumonia and acute respiratory distress syndrome are the major complications of COVID‐19. SARS‐CoV‐2 infection can activate innate a…
View article: Intellectual Disability in Morocco: A Pilot Study.
Intellectual Disability in Morocco: A Pilot Study. Open
Objective: Intellectual disability (ID) is a heterogeneous group of disorders characterized by a congenital limitation in intellectual functioning and adaptive behaviour. Our present work aimed to describe the demographic and clinic…
View article: The Effect of β-<scp>d</scp>-Mannuronic Acid in Animal Model of Epilepsy
The Effect of β-<span>d</span>-Mannuronic Acid in Animal Model of Epilepsy Open
In the present study, we aimed to evaluate the therapeutic efficacy of β-d-mannuronic acid (M2000) in a rat model of epilepsy. Pentylenetetrazole (PTZ)-induced kindling model was applied in 30 Wistar rats divided into 3 groups through a to…
View article: Cost-utility analysis of Macitentan Vs. Bosentan in pulmonary atrial hypertension
Cost-utility analysis of Macitentan Vs. Bosentan in pulmonary atrial hypertension Open
Macitentan is preferable to and dominant over bosentan in both effectiveness and expenditure. Thus, the therapeutic regimen containing macitentan is introduced as a favorable treatment strategy.
View article: PRS13 COST-UTILITY ANALYSIS OF MACITENTAN IN COMPARISON WITH BOSENTAN IN PULMONARY ATRIAL HYPERTENSION (PAH)
PRS13 COST-UTILITY ANALYSIS OF MACITENTAN IN COMPARISON WITH BOSENTAN IN PULMONARY ATRIAL HYPERTENSION (PAH) Open