Haleluya Wami
YOU?
Author Swipe
View article: A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system
A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system Open
Gonorrhoea is a major sexually transmitted infection and the emergence of multidrug-resistant Neisseria gonorrhoeae poses a global health threat. To identify candidate antibiotics against N. gonorrhoeae , we screened Pseudomonas aeruginosa…
View article: Serial passage in an insect host indicates genetic stability of the human probiotic<i>Escherichia coli</i>Nissle 1917
Serial passage in an insect host indicates genetic stability of the human probiotic<i>Escherichia coli</i>Nissle 1917 Open
Background and objectives The probiotic Escherichia coli strain Nissle 1917 (EcN) has been shown to effectively prevent and alleviate intestinal diseases. Despite the widespread medical application of EcN, we still lack basic knowledge abo…
View article: The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic <i>Escherichia coli</i> (UPEC/EAEC) isolated from a urinary tract infection
The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic <i>Escherichia coli</i> (UPEC/EAEC) isolated from a urinary tract infection Open
Enteroaggregative Escherichia coli (EAEC) comprises an important diarrheagenic pathotype, while uropathogenic E. coli (UPEC) is the most important agent of urinary tract infection (UTI). Recently, EAEC virulence factors have been detected …
View article: Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study
Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study Open
The resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. E. coli strains, which are among the most common uropathogens, a…
View article: Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations
Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations Open
The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing dsDNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54 kb genomic region in Enterobacteriac…
View article: Comparative Genomics of Emerging Lineages and Mobile Resistomes of Contemporary Broiler Strains of Salmonella Infantis and E. coli
Comparative Genomics of Emerging Lineages and Mobile Resistomes of Contemporary Broiler Strains of Salmonella Infantis and E. coli Open
Introduction Commensal and pathogenic strains of multidrug-resistant (MDR) Escherichia coli and non-typhoid strains of Salmonella represent a growing foodborne threat from foods of poultry origin. MDR strains of Salmonella Infantis and E. …
View article: Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity
Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity Open
A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut–CNS axis can be shaped by dietary factors, either dir…
View article: Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinants
Diversity and prevalence of colibactin- and yersiniabactin encoding mobile genetic elements in enterobacterial populations: insights into evolution and co-existence of two bacterial secondary metabolite determinants Open
1 Abstract The bacterial genotoxin colibactin interferes with the eukaryotic cell cycle by causing double-stranded DNA breaks. It has been linked to bacterially induced colorectal cancer in humans. Colibactin is encoded by a 54-kb genomic …
View article: Comparative genomics of emerging lineages and mobile resistomes of contemporary broiler strains of<i>Salmonella</i>Infantis and<i>E. coli</i>
Comparative genomics of emerging lineages and mobile resistomes of contemporary broiler strains of<i>Salmonella</i>Infantis and<i>E. coli</i> Open
Introduction Commensal and pathogenic strains of MDR Escherichia coli and non-typhoid strains of Salmonella represent a growing foodborne threat from foods of poultry origin. MDR strains of S . Infantis and E. coli are frequently isolated …
View article: Serial passage of the human probiotic<i>E. coli</i>Nissle 1917 in an insect host leads to changed bacterial phenotypes
Serial passage of the human probiotic<i>E. coli</i>Nissle 1917 in an insect host leads to changed bacterial phenotypes Open
Summary Probiotics are living microorganisms that are increasingly and successfully used for the therapy of various diseases. The most common use of probiotics is the therapeutic and preventive application for gastrointestinal disorders. T…
View article: The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic <i>Escherichia coli</i> (UPEC/EAEC) isolated from a urinary tract infection
The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic <i>Escherichia coli</i> (UPEC/EAEC) isolated from a urinary tract infection Open
Enteroaggregative Escherichia coli (EAEC) comprises an important diarrheagenic pathotype, while uropathogenic E. coli (UPEC) is the most important agent of urinary tract infection (UTI). Recently, EAEC virulence factors have been detected …
View article: A recently isolated human commensal <i>Escherichia coli</i> ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage‐derived IncY plasmid
A recently isolated human commensal <i>Escherichia coli</i> ST10 clone member mediates enhanced thermotolerance and tetrathionate respiration on a P1 phage‐derived IncY plasmid Open
The ubiquitous human commensal Escherichia coli has been well investigated through its model representative E. coli K‐12. In this work, we initially characterized E. coli Fec10, a recently isolated human commensal strain of phylogroup A/se…
View article: Erratum for Wallenstein et al., “ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli”
Erratum for Wallenstein et al., “ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli” Open
International audience
View article: ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli Open
The nonribosomal peptide/polyketide hybrid colibactin can be considered a bacterial virulence factor involved in extraintestinal infection and also a procarcinogen. Nevertheless, and despite its genotoxic effect, colibactin expression can …
View article: Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <scp>S100A8</scp>/<scp>A9</scp> alarmins, and <scp>MHC</scp> H‐2 haplotype
Spontaneous onset of TNFα‐triggered colonic inflammation depends on functional T lymphocytes, <span>S100A8</span>/<span>A9</span> alarmins, and <span>MHC</span> H‐2 haplotype Open
Recently, we established a doxycycline‐inducible human tumor necrosis factor alpha (TNFα)‐transgenic mouse line, ihTNFtg. Non‐induced young and elderly mice showed low but constitutive expression of hTNFα due to promoter leakiness. The per…
View article: Genome Sequence of the Fish Brain Bacterium Clostridium tarantellae
Genome Sequence of the Fish Brain Bacterium Clostridium tarantellae Open
Eubacterium tarantellae was originally cultivated from the brain of fish affected by twirling movements. Here, we present the draft genome sequence of E. tarantellae DSM 3997, which consists of 3,982,316 bp. Most protein-coding genes in th…