Haley Abel
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View article: Structural and transduction patterns of human-specific polymorphic SVA insertions
Structural and transduction patterns of human-specific polymorphic SVA insertions Open
View article: Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers
Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers Open
Whole-genome sequencing (WGS) is a comprehensive approach for the genomic evaluation of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). We recently described a streamlined tumor-only WGS assay (ChromoSeq) that uses Illumi…
View article: Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer
Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer Open
DNA methylation is altered in all cancers, but the mechanisms responsible for these changes are not well understood. Using data from 100 primary samples, we show that regions with intermediate methylation in normal hematopoietic cells are …
View article: Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity
Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity Open
Here, we characterize the DNA methylation phenotypes of bone marrow cells from mice with hematopoietic deficiency of Dnmt3a or Dnmt3b (or both enzymes) or expressing the dominant-negative Dnmt3a R878H mutation [R882H in humans; the most co…
View article: FIGURE 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Mutations in AID motifs at SOCS1. A, Schematic of SOCS1 gene structure. Middle track shows where SOCS1 SNVs are located. Zoomed-in tracks (top and bottom) show the location of WRC/GYW motifs and the mutations that lie …
View article: Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Diagram of observed mutated components of the PI3K signaling cascade
View article: FIGURE 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
JAK/STAT signaling. A, Diagram of components of the JAK/STAT signaling cascade. Identified SMGs are shown in red; genes mutated in at least one non-hypermutated sample are shown in yellow; genes mutated only in the hypermutated samp…
View article: Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Observed COSMIC v.3 mutation signatures
View article: Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution Partitioned by Validation Status
View article: Supplementary Figure 9 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 9 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Co-Occurrence and Mutual Exclusivity Among Significantly Mutated Genes
View article: FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Recurrently mutated genes in Hodgkin lymphoma. The frequency and type of mutations affecting genes mutated in 3 or more patients in our cohort are shown in each row. Genes determined to be significantly mutated using MuSiC and/or dN/dScv (…
View article: FIGURE 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Regulating Hippo. A, Diagram of pathways that regulate Hippo signaling. Identified SMGs are shown in red; genes mutated in at least one non-hypermutated sample are shown in yellow; genes only mutated in the hypermutated sample (HL-5…
View article: Supplementary Figure 8 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 8 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Comparison of Genes Shown to be Recurrently Mutated in Studies of Adult cHL
View article: Supplementary Figure 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome VAF and Depth of Coverage
View article: Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution and Exome Tumor Coverage Partitioned by Validation Status
View article: Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Observed COSMIC v.3 mutation signatures
View article: Supplementary Figure 15 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 15 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
VAF Distribution of JAK/STAT and Hippo/TAZ/YAP regulation associated variants
View article: Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Haloplex amplicons
View article: Supplementary Tables 1-14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Tables 1-14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Supplemental Tables 1-14
View article: Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 4 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution Partitioned by Validation Status
View article: Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 17 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Diagram of observed mutated components of the PI3K signaling cascade
View article: Supplementary Figure 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 6 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Coverage Summary Across Sites that Passed and Failed Validation
View article: Supplementary Figure 10 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 10 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Comparison of mutation burden and EBV status
View article: Supplementary Figure 12 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 12 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Normalized Expression of EIF4A2
View article: FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
FIGURE 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Recurrently mutated genes in Hodgkin lymphoma. The frequency and type of mutations affecting genes mutated in 3 or more patients in our cohort are shown in each row. Genes determined to be significantly mutated using MuSiC and/or dN/dScv (…
View article: Supplementary Figure 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 2 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome VAF and HaloPlex Tumor VAF
View article: Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Data File 1 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Haloplex amplicons
View article: Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 5 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Exome Tumor VAF Distribution and Exome Tumor Coverage Partitioned by Validation Status
View article: Supplementary Tables 1-14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Tables 1-14 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Supplemental Tables 1-14
View article: Supplementary Figure 3 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma
Supplementary Figure 3 from Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma Open
Relationship between Variant Validation Rate and The Number of HRS Cells/HPF