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View article: Heterogeneous PSMA ligand uptake inside parotid glands
Heterogeneous PSMA ligand uptake inside parotid glands Open
Uptake of PSMA PET is heterogeneous within parotid glands, with uptake biased towards lateral/posterior regions. Uptake within parotid glands was strongly correlated with CT texture feature maps.
View article: Image denoising and model-independent parameterization for IVIM MRI
Image denoising and model-independent parameterization for IVIM MRI Open
Objective . To improve intravoxel incoherent motion imaging (IVIM) magnetic resonance Imaging quality using a new image denoising technique and model-independent parameterization of the signal versus b -value curve. Approach . IVIM images …
View article: Neural blind deconvolution for deblurring and supersampling PSMA PET
Neural blind deconvolution for deblurring and supersampling PSMA PET Open
Objective . To simultaneously deblur and supersample prostate specific membrane antigen (PSMA) positron emission tomography (PET) images using neural blind deconvolution. Approach . Blind deconvolution is a method of estimating the hypothe…
View article: Analysis of left ventricle regional myocardial motion for cardiac radioablation
Analysis of left ventricle regional myocardial motion for cardiac radioablation Open
Purpose Left ventricle (LV) regional myocardial displacement due to cardiac motion was assessed using cardiovascular magnetic resonance (CMR) cine images to establish region‐specific margins for cardiac radioablation treatments. Methods CM…
View article: PSMA PET/CT as a predictive tool for subregional importance estimates in the parotid gland
PSMA PET/CT as a predictive tool for subregional importance estimates in the parotid gland Open
Objective . Xerostomia and radiation-induced salivary gland dysfunction remain a common side effect for head-and-neck radiotherapy patients, and attempts have been made to quantify the heterogeneity of the dose response within parotid glan…
View article: Image denoising and model-independent parameterization for improving IVIM MRI
Image denoising and model-independent parameterization for improving IVIM MRI Open
Variability of IVIM parameters throughout the literature is a long-standing issue, and perfusion-related parameters are difficult to interpret. We demonstrate for improving the analysis of intravoxel incoherent motion imaging (IVIM) magnet…
View article: Investigating heterogeneous PSMA ligand uptake inside parotid glands
Investigating heterogeneous PSMA ligand uptake inside parotid glands Open
The purpose was to investigate the spatial heterogeneity of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) uptake within parotid glands. We aim to quantify patterns in well-defined regions to facilitate furthe…
View article: PSMA PET/CT as a predictive tool for sub-regional importance estimates in the parotid gland
PSMA PET/CT as a predictive tool for sub-regional importance estimates in the parotid gland Open
Xerostomia and radiation-induced salivary gland dysfunction remain a common side effect for head-and-neck radiotherapy patients, and attempts have been made to quantify the heterogeneous dose response within parotid glands. Here several mo…
View article: Neural blind deconvolution for deblurring and supersampling PSMA PET
Neural blind deconvolution for deblurring and supersampling PSMA PET Open
Objective: To simultaneously deblur and supersample prostate specific membrane antigen (PSMA) positron emission tomography (PET) images using neural blind deconvolution. Approach: Blind deconvolution is a method of estimating the hypotheti…
View article: Development of a CT-Based Auto-Segmentation Model for Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography-Delineated Tubarial Glands
Development of a CT-Based Auto-Segmentation Model for Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography-Delineated Tubarial Glands Open
Modern inverse planning radiotherapy techniques allow for organs at risk (OARs) to evade radiation doses that they would have been subjected to with earlier techniques. The extent to which patient outcomes may be improved using these techn…
View article: Radiomics-guided radiation therapy: opportunities and challenges
Radiomics-guided radiation therapy: opportunities and challenges Open
Radiomics is an advanced image-processing framework, which extracts image features and considers them as biomarkers towards personalized medicine. Applications include disease detection, diagnosis, prognosis, and therapy response assessmen…
View article: Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans
Incorporating parotid gland inhomogeneity into head‐and‐neck treatment optimization through the use of artificial base plans Open
Despite a great improvement in target volume dose conformality made possible in recent years by modulated therapies, xerostomia remains a common and severe side effect for head‐and‐neck radiotherapy patients. It is known that parotid gland…
View article: Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary
Inflammaging is associated with shifted macrophage ontogeny and polarization in the aging mouse ovary Open
The fertility of women declines sharply after age 35 and is essentially lost upon menopause at age 51. The ovary plays an important part in aging-associated changes in women’s physiology since it is an essential component of both the repro…
View article: Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary
Dysfunctional MDR-1 disrupts mitochondrial homeostasis in the oocyte and ovary Open
Multidrug resistance transporters (MDRs) are best known for their pathological role in neoplastic evasion of chemotherapeutics and antibiotics. Here we show that MDR-1 is present in the oocyte mitochondrial membrane, and it protects the fe…
View article: Assessment of spatially inhomogeneous intra-organ radiation dose response in salivary glands
Assessment of spatially inhomogeneous intra-organ radiation dose response in salivary glands Open
Cancers treated with radiotherapy must be adequately irradiated to suppress growth at the site of origin. To achieve doses high enough to attain ‘local control’ and inhibit growth of metastases, surrounding normal tissues are selectively c…
View article: Prefer Nested Segmentation to Compound Segmentation
Prefer Nested Segmentation to Compound Segmentation Open
Introduction: Intra-organ radiation dose sensitivity is becoming increasingly relevant in clinical radiotherapy. One method for assessment involves partitioning delineated regions of interest and comparing the relative contributions or imp…
View article: Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation Open
1Department of Physics and Astronomy, University of British Columbia, Vancouver, British Columbia, Canada, 2Department of Medical Physics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, 3Department of Medicine and App…
View article: Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation Open
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
View article: Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation Open
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
View article: Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation Open
Development of a method for functional aspect identification in parotid using dynamic contrast-enhanced magnetic resonance imaging and concurrent stimulation