Haley Steiner
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View article: Loss of Paneth cells dysregulates gut ILC subsets and enhances weight gain response to high fat diet in a mouse model
Loss of Paneth cells dysregulates gut ILC subsets and enhances weight gain response to high fat diet in a mouse model Open
Obesity has been associated with dysbiosis, but innate mechanisms linking intestinal epithelial cell subsets and obesity remain poorly understood. Using mice lacking Paneth cells (Sox9 ΔIEC mice), small intestinal epithelial cells speciali…
View article: NEI supplementation improves alum-based immunity in CFTR KO mice
NEI supplementation improves alum-based immunity in CFTR KO mice Open
Cystic fibrosis (CF) is a genetic disorder that causes severe damage to the lungs and digestive system. CF affects the cells that produce mucus, sweat, and digestive enzymes and is caused by mutations in the Cystic Fibrosis Transmembrane C…
View article: Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity Open
Significance We report that suppression of the serine protease elastase reshapes innate responses induced by injected vaccines containing alum adjuvant. This reprogramming improves the induction of protective antibodies in the bloodstream …
View article: Contents: Eur. J. Immunol. 8'18
Contents: Eur. J. Immunol. 8'18 Open
View article: Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG‐ and IgA‐producing cells
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG‐ and IgA‐producing cells Open
It is well established that dendritic cells and macrophages play a role in antigen presentation to B and T cells and in shaping B and T cell responses via cytokines they produce. We have previously reported that depletion of neutrophils im…
View article: Sublingual targeting of STING with 3′3′-cGAMP promotes systemic and mucosal immunity against anthrax toxins
Sublingual targeting of STING with 3′3′-cGAMP promotes systemic and mucosal immunity against anthrax toxins Open
View article: Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization
Neutrophils negatively regulate induction of mucosal IgA responses after sublingual immunization Open