H. Fox
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View article: Aging of the placenta
Aging of the placenta Open
Imino sugars are used to treat type 2 diabetes mellitus [miglitol (Glyset)] and lysosomal storage disorders [miglustat (Zavesca)] based on the inhibition of α-glucosidases and glucosyltransferases. In this substrate specificity study, we e…
View article: Gestational trophoblastic disease
Gestational trophoblastic disease Open
The term gestational trophoblastic disease includes hydatidiform moles, invasive hydatidiform moles, and choriocarcinoma. However, many gynaecologists and oncologists seem to consider that these conditions represent a neoplastic spectrum, …
View article: Prognostic value of epidermal growth factor receptor expression in cervical carcinoma.
Prognostic value of epidermal growth factor receptor expression in cervical carcinoma. Open
Immunohistochemical demonstration of epidermal growth factor receptor expression may be useful in identifying those patients with a poor prognosis, particularly those with adenosquamous carcinomas which have not metastasised to the regiona…
View article: Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles.
Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles. Open
AIMS: To determine whether the expression of proliferating cell nuclear antigen (PCNA) in villous cytotrophoblast could distinguish between placental tissue from a hydropic abortion and that from a partial hydatidiform mole. METHODS: Tissu…
View article: Prognostic value of c-erbB-2 expression in uterine cervical carcinoma.
Prognostic value of c-erbB-2 expression in uterine cervical carcinoma. Open
AIMS: To study the pattern of expression and prognostic importance of c-erbB-2 protein in cervical carcinoma. METHODS: Sixty two cases of stage IB/IIA cervical carcinoma, representing the three main tumour types, were investigated immunohi…
View article: Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain.
Human serum Cohn fraction IV (alpha-globulin [correction of globin] enriched) inhibits ligand binding at neurotransmitter receptors in human brain. Open
Human serum proteins are found in significant density in the neuropil in brains of demented individuals. The functional significance of these abnormally distributed proteins has been unknown. We now report that alpha-globulin-enriched frac…
View article: Vulvar intraepithelial neoplasia and microinvasive carcinoma of the vulva.
Vulvar intraepithelial neoplasia and microinvasive carcinoma of the vulva. Open
The pathological, cytological, and clinical features of vulvar intraepithelial neoplasia (VIN) are described. The rate of progression of VIN III to an invasive carcinoma is very low and spontaneous regression can occur. These features prev…
View article: Neuroblastoma arising in a mature cystic teratoma of the ovary
Neuroblastoma arising in a mature cystic teratoma of the ovary Open
A case is described of a neuroblastoma which appeared to arise in a mature cystic teratoma of the ovary. The literature concerning neural tumours of the ovary is briefly reviewed and the grounds for believing that the development of such n…
View article: Malignant fibrous histiocytomas of salivary glands
Malignant fibrous histiocytomas of salivary glands Open
The light microscopic, immunohistological and ultrastructural findings in two cases of malignant fibrous histiocytoma arising in salivary glands are presented and the features of seven previously reported cases are reviewed. This neoplasm …
View article: Cervical intraepithelial neoplasia.
Cervical intraepithelial neoplasia. Open
The theoretical and practical reasons for replacing the terms "cervical dysplasia" and "cervical carcinoma in situ" by the single diagnostic entity of "cervical intraepithelial neoplasia" are reviewed and the advantages and drawbacks of th…
View article: An immunohistochemical study of distribution of carcinoembryonic antigen in epithelial tumours of the ovary.
An immunohistochemical study of distribution of carcinoembryonic antigen in epithelial tumours of the ovary. Open
An immunohistochemical study of the tissue CEA content of 82 epithelial neoplasms of the ovary has shown that mucinous tumours contain more of this substance than do their serous counterparts; otherwise a knowledge of tissue CEA content ap…
View article: An immunohistochemical study of the significance of HCG secretion by large bowel adenocarcinomata.
An immunohistochemical study of the significance of HCG secretion by large bowel adenocarcinomata. Open
A series of five benign and 60 malignant colonorectal neoplasms has been examined immunohistochemically for the presence of HCG. This hormone was not demonstrated in any of the benign tumours but was present in 43% of the malignant neoplas…
View article: Ectopic production of salivary type amylase by a pseudomesotheliomatous carcinoma of the lung
Ectopic production of salivary type amylase by a pseudomesotheliomatous carcinoma of the lung Open
A pseudomesotheliomatous carcinoma of the lung which appeared to be ectopically secreting large quantities of salivary (S) type amylase is described. This unusual variant of adenocarcinoma may mimic a mesothelioma, but is distinguished fro…
View article: A possible role for placental lysosomes in the formation of villous syncytiotrophoblast
A possible role for placental lysosomes in the formation of villous syncytiotrophoblast Open
An ultrastructural and ultrahistochemical study of first trimester human placentae confirms previous reports that the cytotrophoblastic cells show a spectrum of differentiation, that dissolution of the limiting membrane of the cytotrophobl…
View article: The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.
The distribution of mucosal antibodies in the bowel of patients with Crohn's disease. Open
Specimens of intestine from 24 patients with histologically proven Crohn's disease have been studies by an immunofluorescent technique for the distribution of immunoglobulins A, G, M, E, and D. A marked reduction of IgA in lymphoid and epi…
View article: A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis Open
Ninety-two cases of granulosa cell tumor of the ovary have been studied. The clinical and pathologic data from this group were similar to that obtained in previous series. Because of the long natural history of many granulosa cell tumors, …
View article: An immunofluorescent study of the distribution of immunoglobulin-containing cells in the normal and the inflamed human gall bladder
An immunofluorescent study of the distribution of immunoglobulin-containing cells in the normal and the inflamed human gall bladder Open
Immunoglobulin-containing cells are present in the normal human gall bladder but they are much less numerous in this site than in the normal intestine. IgA-containing cells predominate in the mucosa but in the muscle layer IgM cells are th…
View article: Leiomyosarcoma of the penis
Leiomyosarcoma of the penis Open
A case of leiomyosarcoma of the penis is described. The previous reports of this tumor are summarized, and the prognosis and treatment are discussed.
View article: Haemangiomata of the placenta
Haemangiomata of the placenta Open
A series of six placental haemangiomata is described. Of these one was large and was associated clinically with hydramnios and premature labour. The remaining five were discovered in the course of a systemic examination of 500 unselected p…