Cory White
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View article: Dystrophin Dp71 is essential for the development and function of macrophages
Dystrophin Dp71 is essential for the development and function of macrophages Open
Mutations in the DMD gene, encoding dystrophins, cause progressive muscle degeneration with severe sterile inflammation. While macrophages predominate amongst muscle-infiltrating cells, being central to both damage and regeneration, they w…
View article: Very early life microbiome and metabolome correlates with primary vaccination variability in children
Very early life microbiome and metabolome correlates with primary vaccination variability in children Open
Despite multiple vaccine doses early in life, a substantial proportion of infants do not mount protective responses. In this study, we followed a cohort of children over the first 2 years of life, collecting microbiome and metabolome data …
View article: μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping
μMap Photoproximity Labeling Enables Small Molecule Binding Site Mapping Open
The characterization of ligand binding modes is a crucial step in the drug discovery process and is especially important in campaigns arising from phenotypic screening, where the protein target and binding mode are unknown at the outset. E…
View article: Unraveling novel crosstalk between distinct neutrophil subsets and soluble plasma factors in sepsis and ARDS
Unraveling novel crosstalk between distinct neutrophil subsets and soluble plasma factors in sepsis and ARDS Open
Sepsis is a life-threatening condition caused by an aberrant immune response to infection and subsequent organ dysfunction. Further, due to shared mechanisms such as severe inflammation and endothelial dysfunction, sepsis remains the most …
View article: Supplementary Materials from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Materials from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Materials - PDF files 113K, Materials and Methods
View article: Supplementary Figure 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure 1 - PDF files 5795K, Induction of apoptosis by NXD30001 in NF2-deficient cells
View article: Supplementary Table 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Table 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Table 2 - XLS file 40K, qPCR validation of transcriptome
View article: Supplementary Figure Legends from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure Legends from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure Legends - PDF files 65K, Figure Legends
View article: Supplementary Figure 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure 1 - PDF files 5795K, Induction of apoptosis by NXD30001 in NF2-deficient cells
View article: Supplementary Table 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Table 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Table 2 - XLS file 40K, qPCR validation of transcriptome
View article: Supplementary Table 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Table 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Table 1 - XLS file 28K, PCR primers for NF2 mutation screening
View article: Supplementary Table 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Table 1 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Table 1 - XLS file 28K, PCR primers for NF2 mutation screening
View article: Supplementary Figure 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure 2 - PDF files 4552K, Global transcriptome profiling of NXD30001 efficacy
View article: Data from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Data from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Purpose: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is e…
View article: Supplementary Figure 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure 2 from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure 2 - PDF files 4552K, Global transcriptome profiling of NXD30001 efficacy
View article: Supplementary Figure Legends from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Figure Legends from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Figure Legends - PDF files 65K, Figure Legends
View article: Data from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Data from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Purpose: The growth and survival of neurofibromatosis type 2 (NF2)–deficient cells are enhanced by the activation of multiple signaling pathways including ErbBs/IGF-1R/Met, PI3K/Akt, and Ras/Raf/Mek/Erk1/2. The chaperone protein HSP90 is e…
View article: Supplementary Materials from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2
Supplementary Materials from Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 Open
Supplementary Materials - PDF files 113K, Materials and Methods
View article: Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 1. Table S1: “Summary of the studies in the meta-analysis for the association between Season of Birth and DNA methylation at birth and in children (age: 1 to 11 years)”. Baseline summary of participants from each of the ind…
View article: Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 5. Table S4: “Direction of differential methylation of CpGs in DMRs of the at-birth and childhood analyses (preliminary analysis”).
View article: Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 6. Table S5: “Genes mapped to DMP/DMR identified in at-birth samples of babies born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associatio…
View article: Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 8. Table S8: “Genes mapped to DMR identified in the childhood samples of children born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associa…
View article: Proteomic Mapping of Intercellular Synaptic Environments via Flavin-Dependent Photoredox Catalysis
Proteomic Mapping of Intercellular Synaptic Environments via Flavin-Dependent Photoredox Catalysis Open
Receptor-ligand interactions play essential signaling roles within intercellular contact regions. This is particularly important within the context of the immune synapse where protein communication at the surface of physically interacting …