Halima M. Said
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View article: Determining the risk-factors for molecular clustering of drug-resistant tuberculosis in South Africa
Determining the risk-factors for molecular clustering of drug-resistant tuberculosis in South Africa Open
Background Drug-resistant tuberculosis (DR-TB) epidemic is driven mainly by the effect of ongoing transmission. In high-burden settings such as South Africa (SA), considerable demographic and geographic heterogeneity in DR-TB transmission …
View article: Tuberculosis control at a South African correctional centre: Diagnosis, treatment and strain characterisation
Tuberculosis control at a South African correctional centre: Diagnosis, treatment and strain characterisation Open
Background Correctional centres provide ideal conditions for tuberculosis (TB) transmission and disease progression. Despite the high TB incidence and incarceration rate in South Africa, data from South African correctional centres are sca…
View article: Additional file 1 of Distribution and Clonality of drug-resistant tuberculosis in South Africa
Additional file 1 of Distribution and Clonality of drug-resistant tuberculosis in South Africa Open
Additional file 1.
View article: Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis Open
South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by b…
View article: Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates Open
Modern advances in genomics provide an opportunity to reinterpret historical bacterial culture collections. In this study, genotypic antibiotic resistance profiles of Mycobacterium tuberculosis isolates from a historical 20-year-old multid…
View article: Whole-Genome Sequence of a <i>Mycobacterium goodii</i> Isolate from a Pediatric Patient in South Africa
Whole-Genome Sequence of a <i>Mycobacterium goodii</i> Isolate from a Pediatric Patient in South Africa Open
We describe here the draft genome sequence of a Mycobacterium goodii isolate from a pediatric patient in Western Cape, South Africa. To our knowledge, this is the second reported genome of this rapidly growing nontuberculous mycobacterial …
View article: Mycobacterium tuberculosis infection in cattle from the Eastern Cape Province of South Africa
Mycobacterium tuberculosis infection in cattle from the Eastern Cape Province of South Africa Open
This is the first report of cases of M. tuberculosis infection in cattle in South Africa. The VNTR profiles of the M. tuberculosis strains identified in the current study will form the basis for creating M. tuberculosis VNTR database for a…
View article: Correlation of rpoB Mutations with Minimal Inhibitory Concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS Endemic Setting, South Africa
Correlation of rpoB Mutations with Minimal Inhibitory Concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS Endemic Setting, South Africa Open
Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recomm…
View article: Evaluation of Semiautomated IS <i>6110</i> -Based Restriction Fragment Length Polymorphism Typing for Mycobacterium tuberculosis in a High-Burden Setting
Evaluation of Semiautomated IS <i>6110</i> -Based Restriction Fragment Length Polymorphism Typing for Mycobacterium tuberculosis in a High-Burden Setting Open
The manual IS 6110 -based restriction fragment length polymorphism (RFLP) typing method is highly discriminatory; however, it is laborious and technically demanding, and data exchange remains a challenge. In an effort to improve IS 6110 -b…
View article: Field evaluation of a novel preservation medium to transport sputum specimens for molecular detection of <i>Mycobacterium tuberculosis</i> in a rural African setting
Field evaluation of a novel preservation medium to transport sputum specimens for molecular detection of <i>Mycobacterium tuberculosis</i> in a rural African setting Open
Objectives To assess the performance of an innovative method of transporting sputum to centralised facilities for molecular detection of Mycobacterium tuberculosis : using a swab to inoculate sputum in a transport medium, PrimeStore ® Mole…
View article: A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings
A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings Open
We conclude that SpoNC provides good discrimination for MDR-TB surveillance and early identification of outbreaks in South Africa, with 24-loci MIRU-VNTR applied for pncA wild-type strains as needed.
View article: High Resolution Melting Curve Analysis for Rapid Detection of Pyrazinamide Resistance in &lt;i&gt;Mycobacterium tuberculosis&lt;/i&gt; Clinical Isolates
High Resolution Melting Curve Analysis for Rapid Detection of Pyrazinamide Resistance in <i>Mycobacterium tuberculosis</i> Clinical Isolates Open
Background: Pyrazinamide (PZA) is one of the most important drugs for tuberculosis (TB) treatment, however, its susceptibility is not routinely tested. High-resolution melting (HRM) curve analysis has been widely used for many applications…