Halime Kalkavan
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View article: Clinical and radiomics parameter prognostication in metastatic uveal melanoma patients treated with hepatic arterial infusion chemotherapy
Clinical and radiomics parameter prognostication in metastatic uveal melanoma patients treated with hepatic arterial infusion chemotherapy Open
Introduction Metastatic uveal melanoma (MUM) has a poor prognosis, but hepatic arterial infusion chemotherapy (HAIC) may improve outcomes in patients with hepatic metastases. To identify reliable prognostic factors for patient stratificati…
View article: Early years, advanced disease: The unmet need in young adults with non-small cell lung cancer
Early years, advanced disease: The unmet need in young adults with non-small cell lung cancer Open
Early-onset LC is characterized by advanced disease stage, adenocarcinoma histopathology and frequent targetable genomic alterations, especially in patients without a history of smoking. Early diagnosis remains a critical unmet medical nee…
View article: Protocol for the establishment of murine orthotopic lung tumors and the assessment of contralateral pulmonal metastasis by flow cytometry
Protocol for the establishment of murine orthotopic lung tumors and the assessment of contralateral pulmonal metastasis by flow cytometry Open
Murine orthotopic tumor models can accurately resemble cancer biology characteristics including metastasis, drug sensitivity, and remodeling of the tumor microenvironment. Here, we present a protocol for establishing murine orthotopic lung…
View article: <scp>ABO</scp>‐Blood Group Associates With Survival Outcomes in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Pembrolizumab Monotherapy
<span>ABO</span>‐Blood Group Associates With Survival Outcomes in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Pembrolizumab Monotherapy Open
Purpose In patients with metastatic non‐small cell lung cancer (NSCLC) with high programmed death‐ligand 1 (PD‐L1) expression, there is still a lack of biomarkers to identify patients with maximum benefit from first‐line treatment with che…
View article: BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK
BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK Open
Expression of BCL-B, an anti-apoptotic BCL-2 family member, is correlated with worse survival in lung adenocarcinomas. Here, we show that BCL-B can mitigate cell death initiation through interaction with the effector protein BOK. We found …
View article: Prognostic value of clinical and radiomic parameters in patients with liver metastases from uveal melanoma
Prognostic value of clinical and radiomic parameters in patients with liver metastases from uveal melanoma Open
Approximately every second patient with uveal melanoma develops distant metastases, with the liver as the predominant target organ. While the median survival after diagnosis of distant metastases is limited to a year, yet‐to‐be‐defined sub…
View article: Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers
Comprehensive pan-cancer analysis of cfDNA methylation marks in tumors reveals complex epigenetic regulatory circuits and diagnostic biomarkers Open
DNA methylation is an extensively studied, stable, and fundamental epigenetic alteration in most cancer types 1 . Single-base-pair resolution analyses of DNA methylation is currently feasible 2 . Analysis of DNA methylation, in liquid biop…
View article: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis
Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis Open
The absence of Caspase-8 or its adapter, Fas-associated death domain (FADD), results in activation of receptor interacting protein kinase-3 (RIPK3)- and mixed-lineage kinase-like (MLKL)–dependent necroptosis in vivo. Here, we show that spo…
View article: Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy
Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy Open
Understanding tumor resistance to T cell immunotherapies is critical to improve patient outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and presentation mach…
View article: Viral infection overcomes ineffectiveness of anti-tumoral CD8+ T cell mediated cytotoxicity
Viral infection overcomes ineffectiveness of anti-tumoral CD8+ T cell mediated cytotoxicity Open
With the integration of PD-1 and CTLA-4 targeting immune checkpoint blockade into cancer treatment regimes, the anti-tumoral cytotoxicity of tumor-specific CD8 + T cells is well established. However, while the unresponsiveness of CD8 + T c…
View article: BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma Open
Whether cell types exposed to a high level of environmental insults possess cell type-specific prosurvival mechanisms or enhanced DNA damage repair capacity is not well understood. BRN2 is a tissue-restricted POU domain transcription facto…
View article: MOMP, cell suicide as a BCL-2 family business
MOMP, cell suicide as a BCL-2 family business Open
Apoptosis shapes development and differentiation, has a key role in tissue homeostasis, and is deregulated in cancer. In most cases, successful apoptosis is triggered by mitochondrial outer membrane permeabilization (MOMP), which defines t…
Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression Open
Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong and prolonged immune activati…
View article: IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts
IL-10 Induces T Cell Exhaustion During Transplantation of Virus Infected Hearts Open
Background/Aims: Unexpected transmissions of viral pathogens during solid organ transplantation (SOT) can result in severe, life-threatening diseases in transplant recipients. Immune activation contributes to disease onset. However mechani…
High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model Open
Background: Graft versus host disease (GvHD) occurs in 20% of cases with patients having an MHC I matched bone marrow transplantation (BMT). Mechanisms causing this disease remain to be studied. Methods: Here we used a CD8+ T cell transgen…