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View article: High-fidelity 3D models of human cadavers and their organs with the use of handheld scanner–Alternative method in medical education and clinical practice
High-fidelity 3D models of human cadavers and their organs with the use of handheld scanner–Alternative method in medical education and clinical practice Open
Background Traditional cadaveric dissection is considered the gold standard in anatomical education; however, its accessibility is limited by ethical, logistical, and financial constraints. Recent advancements in three-dimensional (3D) sca…
View article: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment
miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment Open
M2s contribute to the SN microenvironment by secreting IL-34 and thus enhance SN function by upregulating hyperpolarization-activated cyclic nucleotide-gated channel subtype 4. Elevated miR-363-5p, seen in age-related SN dysfunction, may r…
View article: High-resolution 3D visualization of human hearts with emphases on the cardiac conduction system components—a new platform for medical education, mix/virtual reality, computational simulation
High-resolution 3D visualization of human hearts with emphases on the cardiac conduction system components—a new platform for medical education, mix/virtual reality, computational simulation Open
Introduction High-resolution digitized cardiac anatomical data sets are in huge demand in clinical, basic research and computational settings. They can be leveraged to evaluate intricate anatomical and structural changes in disease patholo…
View article: Identifying sex similarities and differences in structure and function of the sinoatrial node in the mouse heart
Identifying sex similarities and differences in structure and function of the sinoatrial node in the mouse heart Open
Background The sinoatrial node (SN) generates the heart rate (HR). Its spontaneous activity is regulated by a complex interplay between the modulation by the autonomic nervous system (ANS) and intrinsic factors including ion channels in SN…
View article: Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs
Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs Open
(1) Background: The sinus node (SN) is the main pacemaker of the heart. It is characterized by pacemaker cells that lack mitochondria and contractile elements. We investigated the possibility that transcription factors (TFs) and microRNAs …
View article: Similarities and differences in morphology, CD31 and CD68 expression of male vs. female sinoatrial node and its surrounding atrial muscle in ageing and obesity
Similarities and differences in morphology, CD31 and CD68 expression of male vs. female sinoatrial node and its surrounding atrial muscle in ageing and obesity Open
Research purpose: The sinoatrial node (SN) is the main pacemaker site, and it is located in the junctional area of the superior vena cava within the right atrium (RA). The precise micro-anatomy of the SN in males and females in ageing and …
View article: Anatomical obstacles in cavotricuspid isthmus detected by modified 2D transthoracic echocardiography and long-term outcomes in radiofrequency ablation of typical atrial flutter
Anatomical obstacles in cavotricuspid isthmus detected by modified 2D transthoracic echocardiography and long-term outcomes in radiofrequency ablation of typical atrial flutter Open
Preoperative use of mTTE evaluation helps predict difficulty in cavotricuspid isthmus radiofrequency ablation, thus allowing better planning of the radiofrequency ablation strategy using the most accurate radiofrequency ablation electrode.
View article: Innovations in cardiac conduction system research: Female frontiers and global disparities
Innovations in cardiac conduction system research: Female frontiers and global disparities Open
Background: The cardiac conduction system (CCS) initiates and propagates electrical impulses across the heart. Scientists of both sexes have played unprecedented roles in discovering the CCS and advancing our anatomical, electrophysiologic…
View article: Interactive teaching of medical 3D cardiac anatomy: atrial anatomy enhanced by ECG and 3D visualization
Interactive teaching of medical 3D cardiac anatomy: atrial anatomy enhanced by ECG and 3D visualization Open
The most commonly applied way of teaching students to convey the foundations of human anatomy and physiology involves textbooks and lectures. This way of transmitting knowledge causes difficulties for students, especially in the context of…
View article: Morphology of human sinoatrial node and its surrounding right atrial muscle in the global obesity pandemic—does fat matter?
Morphology of human sinoatrial node and its surrounding right atrial muscle in the global obesity pandemic—does fat matter? Open
Introduction The sinus node (SN) is the main pacemaker site of the heart, located in the upper right atrium at the junction of the superior vena cava and right atrium. The precise morphology of the SN in the human heart remains relatively …
View article: MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment
MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment Open
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that play a role in post-transcriptional gene regulation. It is generally accepted that their main mechanism of action is the negative regulation of gene expression, through …
View article: Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension
Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension Open
Patients with pulmonary arterial hypertension (PAH) have a high burden of arrhythmias, including arrhythmias arising from sinus node dysfunction, and the aim of this study was to investigate the effects of PAH on the sinus node. In the rat…
View article: Atrioventricular node dysfunction in pressure overload-induced heart failure—Involvement of the immune system and transcriptomic remodelling
Atrioventricular node dysfunction in pressure overload-induced heart failure—Involvement of the immune system and transcriptomic remodelling Open
Heart failure is associated with atrioventricular (AV) node dysfunction, and AV node dysfunction in the setting of heart failure is associated with an increased risk of mortality and heart failure hospitalisation. This study aims to unders…
View article: Data from Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension
Data from Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension Open
Data
View article: Topographical anatomy of the left ventricular summit: implications for invasive procedures
Topographical anatomy of the left ventricular summit: implications for invasive procedures Open
The difference in size and content of the LVS is significant, with no correlation to any variable. The size depends on the anatomy of the most prominent septal perforator artery. The superior, inaccessible aspect dominates, and the LVS is …
View article: Editorial: Vascular Disease Multi-Scale Multi-Physics Modeling and Experimental Data
Editorial: Vascular Disease Multi-Scale Multi-Physics Modeling and Experimental Data Open
investigations provide further clarity of experimental-clinical measurements (Hashemi et al., 2021). The relevance of molecules such as nitrous oxide on pertinent health issues 48 are very much possible due to modelling developments by Dr.…
View article: Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals
Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals Open
Research purpose: The cardiac conduction system (CCS) regulates electrical impulses across the heart and cardiac arrhythmias cause structural remodelling of the CCS. Since its discovery over a century ago, the precise anatomy and differenc…
View article: Corrigendum to “Do human sinoatrial node cells have t-tubules?” [Transl. Res. Anat. 25C (2021) 100131]
Corrigendum to “Do human sinoatrial node cells have t-tubules?” [Transl. Res. Anat. 25C (2021) 100131] Open
Background and purpose: Every heartbeat is generated by spontaneously depolarizing specialised nodal cells that make up the sinoatrial node (SN). The SN's unique properties depend on two complex mechanisms - the membrane-voltage and the Ca…
View article: MiR-486-3p and MiR-938—Important Inhibitors of Pacemaking Ion Channels and/or Markers of Immune Cells
MiR-486-3p and MiR-938—Important Inhibitors of Pacemaking Ion Channels and/or Markers of Immune Cells Open
The sinus node (SN) is the heart’s primary pacemaker and has a unique expression of pacemaking ion channels and immune cell markers. The role of microribonucleic acids (miRNAs) in control of ion channels and immune function of the sinus no…
View article: Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit
Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit Open
Background: Purkinje fibers (PFs) control timing of ventricular conduction and play a key role in arrhythmogenesis in heart failure (HF) patients. We investigated the effects of HF on PFs. Methods: Echocardiography, electrocardiography, mi…
View article: Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes
Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes Open
Rationale: Athletes present with atrioventricular node dysfunction manifesting as atrioventricular block. This can necessitate electronic pacemaker implantation, known to be more frequent in athletes with a long training history. Objective…
View article: Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease
Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease Open
Background The sinoatrial/sinus node (SAN) is the primary pacemaker of the heart. In humans, SAN is surrounded by the paranodal area (PNA). Although the PNA function remains debated, it is thought to act as a subsidiary atrial pacemaker (S…