Haller Igel
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View article: Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition
Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition Open
Rare, full-length circular intron RNAs distinct from lariats have been reported in several species, but their biogenesis is not understood. We envisioned and tested a hypothesis for their formation using Saccharomyces cerevisiae , document…
View article: Intron-lariat spliceosomes convert lariats to true circles: implications for intron transposition
Intron-lariat spliceosomes convert lariats to true circles: implications for intron transposition Open
Rare, full length circular intron RNAs distinct from lariats have been reported in several species, but their biogenesis is not understood. We envision and test a hypothesis for their formation using Saccharomyces cerevisiae , documenting …
View article: Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain
Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain Open
Intron branchpoint (BP) recognition by the U2 snRNP is a critical step of splicing, vulnerable to recurrent cancer mutations and bacterial natural product inhibitors. The BP binds a conserved pocket in the SF3B1 (human) or Hsh155 (yeast) U…
View article: Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain
Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain Open
Intron branch point (BP) recognition by the U2 snRNP is a critical step of splicing, vulnerable to recurrent cancer mutations and bacterial natural product inhibitors. The BP binds a conserved pocket in the SF3B1 (human) or Hsh155 (yeast) …
View article: Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling
Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling Open
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotid…
View article: Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling
Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling Open
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotid…
View article: Correction: Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome
Correction: Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome Open
[This corrects the article DOI: 10.1371/journal.pgen.1008249.].
View article: Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome
Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome Open
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes…
View article: Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction
Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction Open
Stable recognition of the intron branchpoint (BP) by the U2 snRNP to form the pre-spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from yeast indicate that Cus2 aids U2 snRNA folding into the stem IIa c…
View article: Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction
Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction Open
Stable recognition of the intron branchpoint by the U2 snRNP to form the pre-spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from yeast indicate that Cus2 aids U2 snRNA folding into the stem IIa confor…
View article: Rapidly evolving protointrons in<i>Saccharomyces</i>genomes revealed by a hungry spliceosome
Rapidly evolving protointrons in<i>Saccharomyces</i>genomes revealed by a hungry spliceosome Open
Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes…