Hamada S. Abulkhair
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View article: A two-decade overview of oxadiazole derivatives as promising anticancer agents
A two-decade overview of oxadiazole derivatives as promising anticancer agents Open
One of the most difficult illnesses that people today must deal with is cancer.
View article: Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles
Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan–ZnO, and chitosan–ZnO/PVP nanoparticles Open
The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability of the procedure for synthesizing such nanoparticles i…
View article: Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan-ZnO, and chitosan-ZnO/PVP nanoparticles
Introducing the antibacterial and photocatalytic degradation potentials of biosynthesized chitosan, chitosan-ZnO, and chitosan-ZnO/PVP nanoparticles Open
The development of nanomaterials has been speedily established in recent years, yet nanoparticles synthesized by traditional methods suffer unacceptable toxicity and the sustainability of the procedure for synthesizing such nanoparticles i…
View article: A taxonomic analysis of the Sudanese medicinal plant, Vachellia nilotica L. (syn: Acacia nilotica L.) based on pods, seeds, and vegetative traits
A taxonomic analysis of the Sudanese medicinal plant, Vachellia nilotica L. (syn: Acacia nilotica L.) based on pods, seeds, and vegetative traits Open
Vachellia nilotica L. (Syn: Acacia nilotica) has puzzled taxonomic history and nomenclature.This study aimed to update the taxonomy of this species in the Sudan by identifying its subspecies and morphological differences among them.The stu…
View article: Geigeria alata- a potential source for anti-Alzheimer’s constituents: In vitro and computational investigations
Geigeria alata- a potential source for anti-Alzheimer’s constituents: In vitro and computational investigations Open
Antioxidants and acetylcholinesterase inhibitors play a key role in the prevention and management of degenerative disorders including Alzheimer’s disease in particular. Identifying new anticholinesterases from natural sources may contribut…
View article: Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments
Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments Open
View article: The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, <i>in vitro</i> , and <i>in silico</i> mechanistic investigations
The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, <i>in vitro</i> , and <i>in silico</i> mechanistic investigations Open
Treatment options for the management of breast cancer are still inadequate. This inadequacy is attributed to the lack of effective targeted medications, often resulting in the recurrence of metastatic disorders. Cumulative evidence suggest…
View article: Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms
Exploring the dual effect of novel 1,4-diarylpyranopyrazoles as antiviral and anti-inflammatory for the management of SARS-CoV-2 and associated inflammatory symptoms Open
View article: Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity Open
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a ferrocene derivative named 1-(5-(diphenylphosphaneyl)cyclopenta-1,3-dien-1-yl)ethyl)imino)-1,3-dihydroisobenzofuran-5-yl)methanol (compound 1…
View article: Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity Open
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a ferrocene derivative named 1-(5-(diphenylphosphaneyl)cyclopenta-1,3-dien-1-yl)ethyl)imino)-1,3-dihydroisobenzofuran-5-yl)methanol (compound 1…
View article: Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from<i>Panicum turgidum</i>
Unravelling the antifungal and antiprotozoal activities and LC-MS/MS quantification of steroidal saponins isolated from<i>Panicum turgidum</i> Open
Bioassay-guided investigation of Panicum turgidum extract resulted in the identification of seven steroidal saponins (Turgidosterones 1–7).
View article: Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity
Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity Open
In this article, we describe a set of subsequent five-steps chemical reactions to synthesize a ferrocene derivative named 1-(5-(diphenylphosphaneyl)cyclopenta-1,3-dien-1-yl)ethyl)imino)-1,3-dihydroisobenzofuran-5-yl)methanol (compound 1…
View article: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NEW 1,2,4-TRIAZOLO QUINAZOLINE DERIVATIVES
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME NEW 1,2,4-TRIAZOLO QUINAZOLINE DERIVATIVES Open
Cancer is a major public health problem in all countries and remains as one of the top leading causes of death worldwide.Herein we report the synthesis of novel series of triazoloquinazolines as potential anticancer agents.Structures of th…
View article: Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization
Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization Open
The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To this end, repurposing of FDA-approved drugs such as NSAIDs against COVID-19 can…
View article: From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity Open
View article: The identification of ketotifen as a novel cardioprotective agent in patients undergoing anthracyclines chemotherapy
The identification of ketotifen as a novel cardioprotective agent in patients undergoing anthracyclines chemotherapy Open
Objective: The present study aimed to investigate the possible cardioprotective effects of ketotifen and to assess its activity as an iron-chelating agent in patients receiving anthracyclines for the treatment of breast cancer. Patients & …
View article: TRIAZOLOPHTHALAZINE INCORPORATING PIPERAZINE DERIVATIVES: SYNTHESIS AND IN VITRO ANTICANCER EVALUATION STUDY
TRIAZOLOPHTHALAZINE INCORPORATING PIPERAZINE DERIVATIVES: SYNTHESIS AND IN VITRO ANTICANCER EVALUATION STUDY Open
Cancer remains as one of the top leading causes of death worldwide in the last decade. In an attempt to develop a potent anticancer agent, herein we are reporting the synthesis of two novel series of piperazinyltriazolophthalazines as pote…
View article: Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis
Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis Open
View article: Synthesis, Characterization and &lt;i&gt;In Vitro&lt;/i&gt; Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives
Synthesis, Characterization and <i>In Vitro</i> Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives Open
A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The structures of the new derivatives were confirmed by the spectral data and elemental analyses. The antitumor activity of this series again…
View article: Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives
Synthesis, Characterization and In Vitro Antitumor Evaluation of New Pyrazolo[3,4-d]Pyrimidine Derivatives Open
A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives was synthesized. The antitumor activity of this series against human breast adenocarcinoma cell line MCF7 was evaluated. Out of twenty new derivatives, ten we…
View article: Synthesis, characterization and antimicrobial evaluation of some novel quinoline derivatives bearing different heterocyclic moieties
Synthesis, characterization and antimicrobial evaluation of some novel quinoline derivatives bearing different heterocyclic moieties Open
A series of 3-substituted 6-methoxy-1H-pyrazolo [3,4-b]quinoline derivatives was synthesized by treating 6-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine (6) with different acid anhydrides including succinic anhydride, maleic anhydride and pht…
View article: Synthesis and preliminary antimicrobial evaluation of some new 6-methoxyquinoline-3-carbonitrile derivatives
Synthesis and preliminary antimicrobial evaluation of some new 6-methoxyquinoline-3-carbonitrile derivatives Open
A series of new 6-methoxyquinoline-3-carbonitrile derivatives were synthesized using a variety of synthetic routes. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysi…