Hamdi M. Hassaneen
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View article: Synthesis, reactions, antitumor and antimicrobial activity of new 5,6-dihydropyrrolo[2,1-a]isoquinoline chalcones
Synthesis, reactions, antitumor and antimicrobial activity of new 5,6-dihydropyrrolo[2,1-a]isoquinoline chalcones Open
View article: Synthesis, Spectral Characterization, and Biological Evaluation of Novel [1,2,4]Triazolo[3,4‐ <i>a</i> ]isoquinolines and 5,6‐Dihydropyrrolo[2,1‐ <i>a</i> ]isoquinolines: Insights From Molecular Docking, ADMET, and Antibacterial Studies
Synthesis, Spectral Characterization, and Biological Evaluation of Novel [1,2,4]Triazolo[3,4‐ <i>a</i> ]isoquinolines and 5,6‐Dihydropyrrolo[2,1‐ <i>a</i> ]isoquinolines: Insights From Molecular Docking, ADMET, and Antibacterial Studies Open
This study discussed the synthesis of novel [1,2,4]triazolo[3,4‐ a ]isoquinolines and 5,6‐dihydropyrrolo[2,1‐ a ]isoquinolines as promising antibacterial agents, showing the significance of isoquinoline scaffold to enhance these biological…
View article: Utility of 6-aza-2-thiothymine in the synthesis of novel [1,2,4]triazolo[4,3-<i>b</i>][1,2,4]triazin-7-one derivatives: synthesis, structure elucidation, molecular docking and <i>in vitro</i> anti-lung cancer activity
Utility of 6-aza-2-thiothymine in the synthesis of novel [1,2,4]triazolo[4,3-<i>b</i>][1,2,4]triazin-7-one derivatives: synthesis, structure elucidation, molecular docking and <i>in vitro</i> anti-lung cancer activity Open
Novel triazolo[4,3- b ][1,2,4]triazin-7-one derivatives (7a–j) were synthesized and tested against PC3, A549, PACA2 and BJ1 cell lines. 7a and 7g were investigated using DNA fragmentation, DNA damage and gene expression and molecular docki…
View article: Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer
Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer Open
A novel series of six [1,2,4]triazolo[3,4- a ]isoquinolin-3-yl)-3-(1,3-diphenyl-1 H -pyrazol-4-yl)prop-2-en-1-ones ( 3a – 3f ) was designed and synthesized. They were characterized based on spectral and elemental analyses. In silico studie…
View article: Convenient synthesis and characterization of new 1,3,4-thiadiazoles and thiazoles incorporating thiophene moiety
Convenient synthesis and characterization of new 1,3,4-thiadiazoles and thiazoles incorporating thiophene moiety Open
View article: Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: <i>in vitro</i> studies
Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: <i>in vitro</i> studies Open
A new series of pyrazole-based chalcones were synthesized and tested against MCF7, PC3, PACA2 and BJ1 as in vitro study. Gene expression, DNA damage, DNA fragmentation and molecular docking for were discussed.
View article: Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR
Design, synthesis and potent anti-pancreatic cancer activity of new pyrazole derivatives bearing chalcone, thiazole and thiadiazole moieties: gene expression, DNA fragmentation, cell cycle arrest and SAR Open
Four pyrazol derivatives (4, 5, 7, and 25) showed potent anti-PACA-2 cell line with IC 50 (13.0, 31.5 and 24.9, 5.5 μg mL −1 ) respectively, while compounds 23 and 25 showed potent anti-PC3 cell line with IC 50 (26.1 and 11.8 μg mL −1 ).
View article: CCDC 2217711: Experimental Crystal Structure Determination
CCDC 2217711: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis Open
Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity. Various functional modifications in chalcones have been reported, along with the…
View article: CCDC 2212615: Experimental Crystal Structure Determination
CCDC 2212615: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt
Novel eco-friendly [1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives efficiency against fungal deterioration of ancient Egyptian mummy cartonnage, Egypt Open
Fungal deterioration is one of the major factors that significantly contribute to mummy cartonnage damage. Isolation and molecular identification of thirteen fungal species contributing to the deterioration of ancient Egyptian mummy carton…
View article: Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549) Open
View article: Synthesis of Novel Hydrazonoyl Chlorides as Useful Precursor in Synthesis of New Thiadiazoles, Selenadiazoles and Triazolotriazines
Synthesis of Novel Hydrazonoyl Chlorides as Useful Precursor in Synthesis of New Thiadiazoles, Selenadiazoles and Triazolotriazines Open
The reaction of hydrazino of pyrazolopyrimidine derivatives with N-phenyl-C-acetylmethanohydrazonoyl chloride afforded the corresponding hydrazonoyl chlorides. The treatment of the obtained hydrazonoyl chlorides with both of potassium thio…
View article: Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents
Synthesis and biological evaluation of new 1,3,4-thiadiazole derivatives as potent antimicrobial agents Open
A series of 1,3,4-thiadiazole derivatives were designed and synthesized using N -(4-nitrophenyl)acetohydrazonoyl bromide and 1-[3,5-dimethyl-1-(4-nitrophenyl)-1 H -pyrazol-4-yl]ethan-1-one as starting materials. The treatment of 1-[3,5-dim…
View article: [1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice
[1,2,4] Triazolo [3,4-a]isoquinoline chalcone derivative exhibits anticancer activity via induction of oxidative stress, DNA damage, and apoptosis in Ehrlich solid carcinoma-bearing mice Open
View article: Synthesis, Cytotoxicity and Docking Simulation of Bioactive [1,2,4]Triazolo[3,4-α]dihydroisoquinoline Chalcone Derivatives
Synthesis, Cytotoxicity and Docking Simulation of Bioactive [1,2,4]Triazolo[3,4-α]dihydroisoquinoline Chalcone Derivatives Open
View article: Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies
Anticancer activity of novel 3‐(furan‐2‐yl)pyrazolyl and 3‐(thiophen‐2‐yl)pyrazolyl hybrid chalcones: Synthesis and in vitro studies Open
Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the corresponding aldehydes 6 afforded the targeted chalcone derivative…
View article: Study The Expression of DYRK1B Gene And Its Association With Metabolic Syndrome Among The Egyptians
Study The Expression of DYRK1B Gene And Its Association With Metabolic Syndrome Among The Egyptians Open
Background: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence…
View article: Overview on Synthesis, Reactions, Applications, and Biological Activities of Schiff Bases
Overview on Synthesis, Reactions, Applications, and Biological Activities of Schiff Bases Open
Schiff bases exhibited various pharmacological and biological activities such as antibacterial, cytotoxic effects, antifungal, and antimalarial. Schiff bases were used for designing organic compounds, metal complexes, or nanoparticles. Als…
View article: Cytotoxic activity, apoptosis induction and cell cycle arrest in human breast cancer (MCF7) cells by a novel fluorinated tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin chalcones
Cytotoxic activity, apoptosis induction and cell cycle arrest in human breast cancer (MCF7) cells by a novel fluorinated tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin chalcones Open
A series of halogenated chalcones ( 3–8 ) was synthesized and confirmed by several spectral tools. The cytotoxic effect of this series was tested against a panel of different cancer cell lines (MCF7, A549, HCT116, and PC3). Our MTT assay r…
View article: Design, synthesis, molecular prediction and biological evaluation of pyrazole-azomethine conjugates as antimicrobial agents
Design, synthesis, molecular prediction and biological evaluation of pyrazole-azomethine conjugates as antimicrobial agents Open
A series of Schiff bases linked with heterocyclic moiety (6a–c, 7a–c, 11a–c, 12a–c, and 13a–c) and ferrocenyl Schiff bases (15a–c) were designed, synthesized, and confirmed based on the spectral da…
View article: Synthesis, Antimicrobial and Antitumor Study of New Pyrido[2,1-a]isoquinolines via Isoquinoline-1-acetonitrile
Synthesis, Antimicrobial and Antitumor Study of New Pyrido[2,1-a]isoquinolines via Isoquinoline-1-acetonitrile Open
View article: CCDC 1943556: Experimental Crystal Structure Determination
CCDC 1943556: Experimental Crystal Structure Determination Open
View article: CCDC 1943555: Experimental Crystal Structure Determination
CCDC 1943555: Experimental Crystal Structure Determination Open
View article: Synthesis of ethynylated biaryls and asymmetric diethynylated benzene via sequential Sonogashira and Suzuki couplings in water
Synthesis of ethynylated biaryls and asymmetric diethynylated benzene via sequential Sonogashira and Suzuki couplings in water Open
Two 1-bromo-4-ethynylbenzene candidates were synthesized from 1-bromo-4-iodobenzene via Sonogashira coupling then sequentially employed in Suzuki coupling with arylboronic acids in water to give ethynylated biaryl derivatives.Optimization …
View article: Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds
Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds Open
Refluxing of (E)-5-amino-1-phenyl-3-styryl-1H-pyrazole-4-carbonitrile 2 with triethylor-thoformate in acetic anhydride afforded the corresponding formimidate 3. Treatment of 3 with hydrazine hydrate in ethanol afforded amino imino compound…