Hamdi Rezigue
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View article: In vitro effects of Mim8 and combined Mim8-bypassing therapy on thrombin generation, thromboelastography and fibrin clot ultrastructure
In vitro effects of Mim8 and combined Mim8-bypassing therapy on thrombin generation, thromboelastography and fibrin clot ultrastructure Open
Mim8 significantly improves TG in vitro in both PPP and PRP from patients with severe HA, with ETP levels comparable to those of FVIII at 100 IU/dL. The TGA can effectively monitor the combined treatment with Mim8 and either rFVIIa or APCC…
View article: In vitro combined haemostatic efficacy of emicizumab and extended half‐life factor VIII compounds
In vitro combined haemostatic efficacy of emicizumab and extended half‐life factor VIII compounds Open
Introduction Early prophylaxis is the gold standard of care for severe haemophilia. The development of subcutaneous Factor VIII (FVIII) mimetics, such as emicizumab, has significantly reduced the disease burden and improved protection agai…
View article: Thrombin Generation Assay to Support Hematologists in the Era of New Hemophilia Therapies
Thrombin Generation Assay to Support Hematologists in the Era of New Hemophilia Therapies Open
Hematology laboratories have traditionally monitored hemophilia replacement therapy by measuring coagulation factors before and after infusion. However, new drugs that do not rely on the replacement of the deficient factor require new appr…
View article: <i>In Vitro</i> Effects of Mim8 and Combined Mim8-Bypassing Therapy on Thrombin Generation and Thromboelastography
<i>In Vitro</i> Effects of Mim8 and Combined Mim8-Bypassing Therapy on Thrombin Generation and Thromboelastography Open
Introduction: Primary prophylaxis is the gold standard of care for severe hemophilia. The development of subcutaneous Factor VIII (FVIII) mimetics has the potential to significantly reduce the disease burden and improve protection against …
View article: Management of Abdominal Aortic Aneurysm Surgery in Glanzmann’s Thrombasthenia Patients with Anti-GPIIb-IIIa Antibodies: A Case Report
Management of Abdominal Aortic Aneurysm Surgery in Glanzmann’s Thrombasthenia Patients with Anti-GPIIb-IIIa Antibodies: A Case Report Open
Glanzmann’s thrombasthenia (GT) is a rare autosomal recessive disorder of platelet function. The frequent occurrence of alloimmunization due to repeated platelet transfusions is the major complication of the disease. Achieving hemostasis i…
View article: Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing
Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing Open
Summary Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compa…
View article: In vitro effect of hydroxyethyl starch on COVID-19 patients–associated hypofibrinolytic state
In vitro effect of hydroxyethyl starch on COVID-19 patients–associated hypofibrinolytic state Open
These results highlight that HES increased apparent in vitro tPA-induced fibrinolysis in case of severe COVID-19 disease. Use of this plasma volume expander may translate as a potential help against COVID-19-induced thrombosis occurrence.
View article: Effects of a Maximal Exercise Followed by a Submaximal Exercise Performed in Normobaric Hypoxia (2500 m), on Blood Rheology, Red Blood Cell Senescence, and Coagulation in Well-Trained Cyclists
Effects of a Maximal Exercise Followed by a Submaximal Exercise Performed in Normobaric Hypoxia (2500 m), on Blood Rheology, Red Blood Cell Senescence, and Coagulation in Well-Trained Cyclists Open
Acute normoxic exercise impacts the rheological properties of red blood cells (RBC) and their senescence state; however, there is a lack of data on the effects of exercise performed in hypoxia on RBC properties. This crossover study compar…