Hameetha Banu Rajamohamed Sait
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View article: Proteomics studies to investigate alterations in the tau interactome under conditions of elevated cellular O‐GlcNAcylation
Proteomics studies to investigate alterations in the tau interactome under conditions of elevated cellular O‐GlcNAcylation Open
Background Neurofibrillary tangles consist of tau protein aggregates and represent a hallmark pathology of Alzheimer’s disease. Tau aggregation, specifically the formation of early aggregates, is believed to be neurotoxic. O‐linked glycosy…
View article: P1‐129: CELL‐AUTONOMOUS AND EFFECTS OF NEURONAL BIN1 LOSS <i>IN VIVO</i>
P1‐129: CELL‐AUTONOMOUS AND EFFECTS OF NEURONAL BIN1 LOSS <i>IN VIVO</i> Open
BIN1 has been identified as the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1-associated SNPs correlate with tau deposition as well as with hippocampal atrophy. Furthermore, while the total amount of…
View article: Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy
Tau antibody chimerization alters its charge and binding, thereby reducing its cellular uptake and efficacy Open
View article: Specific Amyloid β Clearance by a Catalytic Antibody Construct
Specific Amyloid β Clearance by a Catalytic Antibody Construct Open
Classical immunization methods do not generate catalytic antibodies (catabodies), but recent findings suggest that the innate antibody repertoire is a rich catabody source. We describe the specificity and amyloid β (Aβ)-clearing effect of …