Hamid Abuwarda
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View article: <i>Piezo1</i> regulates cholesterol biosynthesis to influence neural stem cell fate during brain development
<i>Piezo1</i> regulates cholesterol biosynthesis to influence neural stem cell fate during brain development Open
Mechanical forces and tissue mechanics influence the morphology of the developing brain, but the underlying molecular mechanisms have been elusive. Here, we examine the role of mechanotransduction in brain development by focusing on Piezo1…
View article: Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
Correction: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open
View article: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open
Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-epithelialization and wound healing; however, the underlying…
View article: Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing
Author response: Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Keratinocytes, the predominan…
View article: Mechanobiology of neural development
Mechanobiology of neural development Open
View article: Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers Open
Piezo channels transduce mechanical stimuli into electrical and chemical signals to powerfully influence development, tissue homeostasis, and regeneration. Studies on Piezo1 have largely focused on transduction of “outside-in” mechanical f…
View article: Myosin-II mediated traction forces evoke localized Piezo1 Ca<sup>2+</sup> flickers
Myosin-II mediated traction forces evoke localized Piezo1 Ca<sup>2+</sup> flickers Open
Piezo channels transduce mechanical stimuli into electrical and chemical signals, and in doing so, powerfully influence development, tissue homeostasis, and regeneration. While much is known about how Piezo1 responds to external forces, it…