Hamid R. Sohrabi
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View article: Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review Open
Exercise can simultaneously impact insulin resistance and Alzheimer's disease pathology in animal models. Results from human research are limited, and no robust evaluation of the potential mediating role of insulin resistance in the physic…
View article: Factors Influencing Staff Support for Sensory Device Use for People in Long-Term Care Settings
Factors Influencing Staff Support for Sensory Device Use for People in Long-Term Care Settings Open
Residents in long-term care settings do not receive adequate support for hearing and vision devices. This study aimed to identify factors influencing support for residents’ daily use of hearing and vision devices. Semi-structured interview…
View article: Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers disease
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimers disease Open
Background:CSF and blood soluble TREM2 (sTREM2) levels have been found to increase at early stage of Alzheimers Disease (AD), albeit plasma levels have been inconclusive. Alterations to AD-related blood biomarkers and brain amyloid beta (A…
View article: The role of diet in moderating the relationship between symptoms of depression and brain amyloid load
The role of diet in moderating the relationship between symptoms of depression and brain amyloid load Open
BACKGROUND Healthy lifestyle factors, including diet, may affect brain amyloid beta (Aβ) load. This study examines dietary patterns as moderators of the relationships among symptoms of depression, anxiety, and brain Aβ load. METHOD A cross…
View article: Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease
Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. AD diagnosis often involves a thorough assessment, including clinical evaluation, cognitive testing, medical history examination, g…
View article: Moderate coffee and tea consumption is associated with slower cognitive decline
Moderate coffee and tea consumption is associated with slower cognitive decline Open
Background Globally, coffee and tea are consumed extensively, potentially providing neuroprotection through anti-inflammatory and antioxidative stress effects. Objective This study aimed to investigate associations between coffee and tea i…
View article: The moderating effect of dietary patterns on the association of depression and anxiety with cognitive function
The moderating effect of dietary patterns on the association of depression and anxiety with cognitive function Open
These findings also emphasise the importance of sex-specific approaches in research on symptoms of depression and anxiety, cognitive health, and diet. Our results highlight the need for further investigation into sex-specific pathways usin…
View article: Longitudinal associations between self‐reported exercise levels and cognition in ADAD
Longitudinal associations between self‐reported exercise levels and cognition in ADAD Open
INTRODUCTION This study examined longitudinal associations between self‐reported exercise and cognition, with moderation by sex, in individuals with autosomal dominant Alzheimer's disease (ADAD) mutations. We also examined whether changes …
View article: Protocol for the Process Evaluation of the SENSE‐Cog Sensory Support Intervention Field Trial to Improve Quality of Life for Older People Receiving Home Care in Australia
Protocol for the Process Evaluation of the SENSE‐Cog Sensory Support Intervention Field Trial to Improve Quality of Life for Older People Receiving Home Care in Australia Open
Background A field trial of a home‐delivered hearing and vision support intervention will assess its impact on the quality of life and well‐being of home care recipients with hearing and/or vision impairment and their care partners. Aims T…
View article: Protocol for a Field Trial of a Hearing and Vision Support Intervention for People Living in Long‐Term Care in Australia
Protocol for a Field Trial of a Hearing and Vision Support Intervention for People Living in Long‐Term Care in Australia Open
Introduction Hearing and vision impairments are prevalent among residents in long‐term care settings. Hearing and vision impairments frequently go unsupported, affecting residents' quality of life and healthcare costs. This paper describes…
View article: Investigating the Impact of Sorghum on Tau Protein Phosphorylation and Mitochondrial Dysfunction Modulation in Alzheimer’s Disease: An In Vitro Study
Investigating the Impact of Sorghum on Tau Protein Phosphorylation and Mitochondrial Dysfunction Modulation in Alzheimer’s Disease: An In Vitro Study Open
Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with poorly understood pathology. Elevated tau, phospho-tau and mitochondrial dysfunction are significantly correlated with an increased risk of AD and are th…
View article: Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection
Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection Open
Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 cont…
View article: Challenges and Opportunities to Support Communication and Reduce Background Noise in Residential Aged Care
Challenges and Opportunities to Support Communication and Reduce Background Noise in Residential Aged Care Open
View article: Baseline energy and nutrient intakes of AU‐ARROW participants using a Food Frequency Questionnaire‐ Preliminary findings
Baseline energy and nutrient intakes of AU‐ARROW participants using a Food Frequency Questionnaire‐ Preliminary findings Open
Background Lifestyle modifications incorporating a healthy diet, physical activity, brain training and health monitoring have proven effective in preventing dementia and related cognitive decline (REF). The Australian‐Multidomain Lifestyle…
View article: The moderating effect of diet on the relationship between depression and Alzheimer’s disease‐related blood‐based biomarker
The moderating effect of diet on the relationship between depression and Alzheimer’s disease‐related blood‐based biomarker Open
Background Interplay between diet, depression, and Alzheimer's disease (AD) shows promise as an important area of study for early intervention and therapy. Associations between both depression and diet and heightened AD risk underscore the…
View article: Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel
Harmonization of data from neuropsychological tests used in different prospective studies‐ Descending a Tower of Babel Open
Background Cognitive dysfunction is central to clinicopathological models of Alzheimer’s disease (AD). While AD prospective studies assess similar cognitive domains, the neuropsychological tests used vary between studies, limiting potentia…
View article: Does education years delay Alzheimer’s disease in cognitively normal oldest old?
Does education years delay Alzheimer’s disease in cognitively normal oldest old? Open
Background Research on cognitive reserve (CR) in individuals aged 80 years old and above has resulted in inconsistent findings, mostly showing a relationship with baseline cognitive abilities but not follow up assessments. The effects of a…
View article: Data‐driven Cognitive Composites and <i>APOE</i> ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults
Data‐driven Cognitive Composites and <i>APOE</i> ε4 Carriage Predict Progression to Mild Cognitive Impairment in Cognitively Unimpaired Older Adults Open
Background In cognitively unimpaired (CU) individuals, the PACC is widely used as a cognitive outcome measure and endpoint in observational studies and clinical trials. However, it has drawn criticism for being heavily weighted towards mem…
View article: Longitudinal associations between self‐reported exercise levels and Alzheimer’s related biomarkers in Autosomal Dominant Alzheimer’s Disease
Longitudinal associations between self‐reported exercise levels and Alzheimer’s related biomarkers in Autosomal Dominant Alzheimer’s Disease Open
Background Accumulating evidence indicates exercise may delay or prevent the onset of Alzheimer’s disease (AD). To our knowledge, no study has investigated the longitudinal impact of exercise on AD‐related biomarkers in individuals with Au…
View article: Insulin resistance’s role in mediating physical activity’s impact on beta amyloid accumulation and tau phosphorylation: A scoping review
Insulin resistance’s role in mediating physical activity’s impact on beta amyloid accumulation and tau phosphorylation: A scoping review Open
Background Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are amongst the top 10 leading causes of death worldwide. T2D is associated with increased AD risk and brain beta amyloid (Aβ) burden, suggesting underlying mechanistic relation…
View article: Investigation the level of Moral Skills Among Dental Students in Tehran Islamic Azad University of Medical Sciences In 2023
Investigation the level of Moral Skills Among Dental Students in Tehran Islamic Azad University of Medical Sciences In 2023 Open
View article: Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning
Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning Open
View article: The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review
The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review Open
Purpose of Review This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings AD and depression are often comorbid, and depression appears to independently increase …
View article: Sorghum Grain Polyphenolic Extracts Demonstrate Neuroprotective Effects Related to Alzheimer’s Disease in Cellular Assays
Sorghum Grain Polyphenolic Extracts Demonstrate Neuroprotective Effects Related to Alzheimer’s Disease in Cellular Assays Open
Sorghum grain contains high levels and a diverse profile of polyphenols (PPs), which are antioxidants known to reduce oxidative stress when consumed in the diet. Oxidative stress leading to amyloid-β (Aβ) aggregation, neurotoxicity, and mi…
View article: Cognitive and neuroscientific perspectives of healthy ageing
Cognitive and neuroscientific perspectives of healthy ageing Open
With dementia incidence projected to escalate significantly within the next 25 years, the United Nations declared 2021-2030 the Decade of Healthy Ageing, emphasising cognition as a crucial element. As a leading discipline in cognition and …
View article: The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU‐ARROW): A study protocol for a single‐blind, multi‐site, randomized controlled trial
The AUstralian multidomain Approach to Reduce dementia Risk by prOtecting brain health With lifestyle intervention study (AU‐ARROW): A study protocol for a single‐blind, multi‐site, randomized controlled trial Open
INTRODUCTION The Finnish Geriatric Intervention Study (FINGER) led to the global dementia risk reduction initiative: World‐Wide FINGERS (WW‐FINGERS). As part of WW‐FINGERS, the Australian AU‐ARROW study mirrors aspects of FINGER, as well a…
View article: Suboptimal self‐reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults
Suboptimal self‐reported sleep efficiency and duration are associated with faster accumulation of brain amyloid beta in cognitively unimpaired older adults Open
INTRODUCTION This study investigated whether self‐reported sleep quality is associated with brain amyloid beta (Aβ) accumulation. METHODS Linear mixed effect model analyses were conducted for 189 cognitively unimpaired (CU) older adults (m…
View article: Editorial: Cerebral amyloid angiopathy: from bench to bedside
Editorial: Cerebral amyloid angiopathy: from bench to bedside Open
Keywords: cerebral amyloid angiopathy (CAA), amyloid-related imaging abnormalities (ARIA), iatrogenic CAA (iCAA), CAA-related inflammation (CAA-ri), fluid biomarkers, peak width of skeletonized mean diffusivity (PSMD), quantitative suscept…
View article: Fluid biomarkers in cerebral amyloid angiopathy
Fluid biomarkers in cerebral amyloid angiopathy Open
Cerebral amyloid angiopathy (CAA) is a type of cerebrovascular disorder characterised by the accumulation of amyloid within the leptomeninges and small/medium-sized cerebral blood vessels. Typically, cerebral haemorrhages are one of the fi…
View article: When Does Alzheimer's Disease Start? Robust Estimates Based on Longitudinal Aβ-Amyloid-PET in Three Large International Cohorts
When Does Alzheimer's Disease Start? Robust Estimates Based on Longitudinal Aβ-Amyloid-PET in Three Large International Cohorts Open