Hamid Sadeghian
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View article: Challenges and Opportunities in the Application of CRISPR-Cas9: A Review on Genomic Editing and Therapeutic Potentials
Challenges and Opportunities in the Application of CRISPR-Cas9: A Review on Genomic Editing and Therapeutic Potentials Open
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated protein 9 (Cas9) constitute a revolutionary gene-editing technology, allowing precise DNA modifications with vast potential for disease treatment …
View article: Comparing self-medication and medical supervised treatment before hospitalization among patients with Covid-19: A retrospective case-control study
Comparing self-medication and medical supervised treatment before hospitalization among patients with Covid-19: A retrospective case-control study Open
The Covid-19 pandemic has caused a surge in the inappropriate use of certain medications through self-medicating. This poses a serious risk to the health of patients, highlighting the need for not only adjusting guidelines but also raising…
View article: A Comparative Study on Visual Detection of Mycobacterium tuberculosis by Closed Tube Loop-Mediated Isothermal Amplification: Shedding Light on the Use of Eriochrome Black T
A Comparative Study on Visual Detection of Mycobacterium tuberculosis by Closed Tube Loop-Mediated Isothermal Amplification: Shedding Light on the Use of Eriochrome Black T Open
Loop-mediated isothermal amplification is a promising candidate for the rapid detection of Mycobacterium tuberculosis. However, the high potential for carry-over contamination is the main obstacle to its routine use. Here, a closed tube LA…
View article: Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and antiangiogenesis in rats fed a high-fat diet
Comparison of eight weeks of resistance training and high-intensity intermittent aerobic training on the expression of microRNAs associated with adipose tissue angiogenesis and antiangiogenesis in rats fed a high-fat diet Open
Background and Purpose: Exercise and obesity alter angiogenesis in adipose tissue, resulting in large changes in metabolic processes. The aim of this study was to compare the effect of eight weeks of resistance training and high-intensity …
View article: Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment
Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment Open
Background Lipoxygenases are one of the critical signaling mediators which can be targeted for human prostate cancer (PC) therapy. In this study, 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) and its two analogs, 4-…
View article: Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy
Design, synthesis and evaluation of PD-L1 peptide antagonists as new anticancer agents for immunotherapy Open
View article: Design, synthesis, and SAR study of isopropoxy allylbenzene derivatives as 15-lipoxygenase inhibitors.
Design, synthesis, and SAR study of isopropoxy allylbenzene derivatives as 15-lipoxygenase inhibitors. Open
Docking results showed that orientation of the amide and allyl moieties of the inhibitors in the active site pocket is the major factor in inhibitory potency variation. Based on the mentioned orientation, for cycloaliphatic amides, by enla…
View article: Cytotoxic effects of hydroxy coumarin derivations to neuroblastoma N2a cells
Cytotoxic effects of hydroxy coumarin derivations to neuroblastoma N2a cells Open
Neuroblastoma is one of the nervous system cancers, which approximately consists of 9% of childhood cancers. In this study, we evaluated the toxic effects of prenyl hydroxy coumarin derivatives on apoptosis of the neuroblastoma cell line N…
View article: Frequency of methicillin-resistant Staphylococcus aureus (MRSA) in nose and cellular phone of medical and non-medical personnel of emergency departments of Ghaem hospital in Mashhad city
Frequency of methicillin-resistant Staphylococcus aureus (MRSA) in nose and cellular phone of medical and non-medical personnel of emergency departments of Ghaem hospital in Mashhad city Open
View article: Effects of Bee Venom on Activity and Expression of 15-Lipoxygenase-1 in Human HT29 Colon Cancer
Effects of Bee Venom on Activity and Expression of 15-Lipoxygenase-1 in Human HT29 Colon Cancer Open
Colorectal cancer (CRC) is known to be the third leading cause of cancer death in both men and women throughout the world (1).In developed countries, CRC is the third most common malignancy.Unfortunately, routine colon cancer therapies suc…
View article: Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors.
Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors. Open
By changing the alcohol and acyl portions of stylosin, it was found that electronic properties play main role in lipoxygenase inhibition potency in contrast with steric features. Insertion of more reductive phenolic moiety such as catechua…
View article: Design of peptides interfering with iron-dependent regulator (IdeR) and evaluation of <i>Mycobacterium tuberculosis</i> growth inhibition.
Design of peptides interfering with iron-dependent regulator (IdeR) and evaluation of <i>Mycobacterium tuberculosis</i> growth inhibition. Open
We introduced two new lead compounds to inhibit Mtb that are promising for the development of more potent anti-tubercular therapies.
View article: Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria.
Novel cilostamide analogs, phosphodiesterase 3 inhibitors, produce positive inotropic but differential lusitropic and chronotropic effects on isolated rat atria. Open
Combination of mc2 with isoprenaline had synergistic effect on inotropic effect, but this combination reduced isoprenaline chronotropic effect; therefore, these effects cannot be related to reducing B-adrenergic receptors activity. These c…
View article: O-prenylated 3-carboxycoumarins as a novel class of 15-LOX-1 inhibitors
O-prenylated 3-carboxycoumarins as a novel class of 15-LOX-1 inhibitors Open
Allyloxy, Isopentenyloxy, geranyloxy and farnesyloxy derivatives of 3-carboxycoumarin, at position 5, 6, 7, and 8, were synthesized and their inhibitory potency against human 15-lipoxygenase-1 (human 15-LOX-1) were determined. Among the sy…
View article: CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse.
CFP10: mFcγ2 as a novel tuberculosis vaccine candidate increases immune response in mouse. Open
The results demonstrated that binding mice Fc-domain to CFP-10 protein can increase the immunogenicity of the subunit vaccine. Further studies, might be able to design and produce a new generation of subunit vaccines based on the Fc-fused …
View article: 2‐Prenylated <i>m</i>‐dimethoxybenzenes as potent inhibitors of 15‐lipo‐oxygenase: inhibitory mechanism and <scp>SAR</scp> studies
2‐Prenylated <i>m</i>‐dimethoxybenzenes as potent inhibitors of 15‐lipo‐oxygenase: inhibitory mechanism and <span>SAR</span> studies Open
15‐lipo‐oxygenases are one of the iron‐containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers…
View article: Epidemiology and the Agreement Rate of Serological Tests in Human Brucellosis in North East of Iran
Epidemiology and the Agreement Rate of Serological Tests in Human Brucellosis in North East of Iran Open
Background: Brucellosis still remains a major health problem with different symptoms and various diagnostic methods. Diagnostic methods of brucellosis are usually based on detecting specific antibodies in the patient's serum. Nowadays, man…
View article: Epidemiology and the Agreement Rate of Serological Tests in Human Brucellosis in North East of Iran
Epidemiology and the Agreement Rate of Serological Tests in Human Brucellosis in North East of Iran Open
Background: Brucellosis still remains a major health problem with different symptoms and various diagnostic methods. Diagnostic methods of brucellosis are usually based on detecting specific antibodies in the patient's serum. Nowadays, man…
View article: Metabolic effects of newly synthesized phosphodiesterase-3 inhibitor 6-[4-(4-methylpiperidin-1-yl)-4-oxobutoxy]-4-methylquinolin-2(1H)-one on rat adipocytes
Metabolic effects of newly synthesized phosphodiesterase-3 inhibitor 6-[4-(4-methylpiperidin-1-yl)-4-oxobutoxy]-4-methylquinolin-2(1H)-one on rat adipocytes Open
Background Clinical use of selective PDE3 inhibitors as cardiotonic agents is limited because of their chronotropic and lipolytic side effects. In our previous work, we synthesized a new PDE3 inhibitor named MC2 (6-[4-(4-methylpiperidin-1-…
View article: Distribution of Hepatitis Delta Virus Genotypes in Mashhad, Northeast Iran
Distribution of Hepatitis Delta Virus Genotypes in Mashhad, Northeast Iran Open
This study showed that the most prevalent genotype of HDV in Mashhad was genotype I. It was of interest that in contrast to other provinces of Iran, HDV genotype 2 was observed in Mashhad. Similar studies with larger sample sizes could pro…