Hamish A. Watson
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View article: Rate constants and Arrhenius parameters for H-atom abstraction from Bu<sub>3</sub>SnH by the 2,2-dimethylvinyl radical in PhMe. Kinetic evidence for an entirely free radical mechanism for the O-directed hydrostannation of alkynols with stannanes and Et<sub>3</sub>B/O<sub>2</sub>
Rate constants and Arrhenius parameters for H-atom abstraction from Bu<sub>3</sub>SnH by the 2,2-dimethylvinyl radical in PhMe. Kinetic evidence for an entirely free radical mechanism for the O-directed hydrostannation of alkynols with stannanes and Et<sub>3</sub>B/O<sub>2</sub> Open
Using the radical 2a as a clock for the 2,2-dimethylvinyl radical 6, a k H-atom abstraction Bu 3 SnH of 2.01 × 10 8 mol −1 s −1 has been estimated for 6 in PhMe at 298 K. The log A of 14.95 for the ring-opening of 2a confirms it is entirel…
View article: Osteopontin (OPN) Downregulatory Alkaloid (-)-Agelastatin A Prevents Muscle Damage in a Mouse Model of Duchenne Muscular Dystrophy
Osteopontin (OPN) Downregulatory Alkaloid (-)-Agelastatin A Prevents Muscle Damage in a Mouse Model of Duchenne Muscular Dystrophy Open
(-)-Agelastatin A (AA) in 1,2-propanediol (3-deoxy-DL-glycerol) elicits a dose-dependent decrease in OPN mRNA expression in canine Duchenne Muscular Dystrophy (DMD) myoblasts at doses ranging from 0.01 nM-30 nM. When intraperitoneally admi…
View article: Osteopontin (OPN) Downregulatory Alkaloid (-)-Agelastatin A Prevents Muscle Damage in a Mouse Model of Duchenne Muscular Dystrophy
Osteopontin (OPN) Downregulatory Alkaloid (-)-Agelastatin A Prevents Muscle Damage in a Mouse Model of Duchenne Muscular Dystrophy Open
(-)-Agelastatin A (AA) in 1,2-propanediol (3-deoxy-DL-glycerol) elicits a dose-dependent decrease in OPN mRNA expression in canine Duchenne Muscular Dystrophy (DMD) myoblasts at doses ranging from 0.01 nM-30 nM. When intraperitoneally admi…
View article: EPR evidence for α-triphenylstannylvinyl radicals in the O-directed hydrostannation of dialkylacetylenes with Ph<sub>3</sub>SnH/cat. Et<sub>3</sub>B/O<sub>2</sub>
EPR evidence for α-triphenylstannylvinyl radicals in the O-directed hydrostannation of dialkylacetylenes with Ph<sub>3</sub>SnH/cat. Et<sub>3</sub>B/O<sub>2</sub> Open
Here we provide definitive EPR evidence for the existence of α-triphenylstannylvinyl radicals such as (Z)-2 in the low temperature O-directed free radical hydrostannation of dialkyl propargylic alcohols with Ph3SnH/cat. Et3…
View article: The stannylvinyl cation that never was! New concentration- and temperature-dependent probe studies confirm an entirely free radical mechanism and O–Sn coordinative control of the hydrostannation of propargylically-oxygenated dialkyl acetylenes with stannanes and cat. Et3B
The stannylvinyl cation that never was! New concentration- and temperature-dependent probe studies confirm an entirely free radical mechanism and O–Sn coordinative control of the hydrostannation of propargylically-oxygenated dialkyl acetylenes with stannanes and cat. Et3B Open
O-Directed free radical hydrostannation of the β-cyclopropyl propargyl alcohol 57 with stannanes and cat. Et3B in THF/H2O or PhMe/MeOH failed to deliver any of the expected products of α-stannylvinyl cation capture. Instead only α-stannyl-…
View article: Fast Ring-Opening of an Intermediary α-Stannyl-β-Cyclopropylvinyl Radical Does Not Support Formation of an α-Stannylvinyl Cation in the O-Directed Free Radical Hydrostannation of Dialkyl Acetylenes
Fast Ring-Opening of an Intermediary α-Stannyl-β-Cyclopropylvinyl Radical Does Not Support Formation of an α-Stannylvinyl Cation in the O-Directed Free Radical Hydrostannation of Dialkyl Acetylenes Open
O-Directed free radical hydrostannation of a β-cyclopropyl propargylic alcohol probe with stannanes and cat. Et 3 B in THF/H 2 O, or PhMe/MeOH, failed to deliver any detectable products of α-stannylvinyl cation capture. Instead only α-stan…
View article: Fast Ring-Opening of an Intermediary α-Stannyl-β-Cyclopropylvinyl Radical Does Not Support Formation of an α-Stannylvinyl Cation in the O-Directed Free Radical Hydrostannation of Dialkyl Acetylenes
Fast Ring-Opening of an Intermediary α-Stannyl-β-Cyclopropylvinyl Radical Does Not Support Formation of an α-Stannylvinyl Cation in the O-Directed Free Radical Hydrostannation of Dialkyl Acetylenes Open
O-Directed free radical hydrostannation of a β-cyclopropyl propargylic alcohol probe with stannanes and cat. Et3B in THF/H2O, or PhMe/MeOH, failed to deliver any detectable products of α-stannylvinyl cation capture. I…
View article: Fast ring-opening of an intermediary α-stannyl-β-cyclopropylvinyl radical does not support formation of an α-stannylvinyl cation in the O-directed free radical hydrostannation of dialkyl acetylenes
Fast ring-opening of an intermediary α-stannyl-β-cyclopropylvinyl radical does not support formation of an α-stannylvinyl cation in the O-directed free radical hydrostannation of dialkyl acetylenes Open
O-directed hydrostannation of β-cyclopropyl propargyl alcohol 22 with stannanes and cat. Et 3 B in THF/H 2 O or PhMe/MeOH fails to deliver any detectable products of α-stannylvinyl cation capture.
View article: The O‐Directed Free Radical Hydrostannation of Propargyloxy Dialkyl Acetylenes with Ph<sub>3</sub>SnH/cat. Et<sub>3</sub>B. A Refutal of the Stannylvinyl Cation Mechanism
The O‐Directed Free Radical Hydrostannation of Propargyloxy Dialkyl Acetylenes with Ph<sub>3</sub>SnH/cat. Et<sub>3</sub>B. A Refutal of the Stannylvinyl Cation Mechanism Open
In this Personal Account, we will give an overview of the room temperature O‐directed free radical hydrostannation reaction of propargylically‐oxygenated dialkyl acetylenes with Ph 3 SnH and catalytic Et 3 B/O 2 in PhMe. We will show how t…