Hamish Forrest
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View article: Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis
Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive adult-onset neurodegenerative diseases with overlapping pathological and genetic origins. They are caused by multiple underlying mechanisms leading to a …
View article: Too big to lose - a FAIR repository for biomedical data derived from home-cage monitoring
Too big to lose - a FAIR repository for biomedical data derived from home-cage monitoring Open
Home-Cage Monitoring (HCM) systems have revolutionised the collection of continuous behavioural data in rodent research and offer unprecedented insights into animal behaviour, yet the full potential of these data remains largely untapped. …
View article: Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the<i>App<sup>NL-G-F</sup></i>knock-in mouse model of the earliest phase of Alzheimer’s disease
Long-read transcriptomic identification of synaptic adaptation to amyloid pathology in the<i>App<sup>NL-G-F</sup></i>knock-in mouse model of the earliest phase of Alzheimer’s disease Open
Genome-wide association studies (GWAS) have identified a transcriptional network of Alzheimer’s disease (AD) risk genes that are primarily expressed in microglia and are associated with AD pathology. However, traditional short-read sequenc…
View article: Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations Open
Variants in the ubiquitously expressed DNA/RNA-binding protein FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS). Most FUS mutation studies have focused on motor neuron degeneration; little is known about wider sys…
View article: Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease
Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease Open
Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies…
View article: FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations
FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations Open
FUS (Fused in sarcoma) is a ubiquitously expressed DNA/RNA binding protein. Mutations in FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS), as in the case with the FUSDelta14 mutation. While most studies have focus…
View article: Comprehensive longitudinal study of home-cage activity, including climbing, reveals new complex phenotypic profile in the N171-82Q HD mouse model with implications for refined preclinical studies
Comprehensive longitudinal study of home-cage activity, including climbing, reveals new complex phenotypic profile in the N171-82Q HD mouse model with implications for refined preclinical studies Open
Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video tracking, in particular, lends itself to automated machine-learning technologies…