Hamsini Suresh
YOU?
Author Swipe
View article: The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment
The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment Open
Subclass cell-types are strongly conserved across mammalian brains, making the systemic absence of a caudal ganglionic eminence (CGE) Pax6 interneuron subclass in mouse transcriptional atlases unexpected. Through cross-species transcriptom…
View article: Solanum pan-genetics reveals paralogues as contingencies in crop engineering
Solanum pan-genetics reveals paralogues as contingencies in crop engineering Open
Pan-genomics and genome-editing technologies are revolutionizing breeding of global crops 1,2 . A transformative opportunity lies in exchanging genotype-to-phenotype knowledge between major crops (that is, those cultivated globally) and in…
View article: Cluster replicability in single-cell and single-nucleus atlases of the mouse brain
Cluster replicability in single-cell and single-nucleus atlases of the mouse brain Open
Single-cell RNA sequencing has advanced our understanding of cellular heterogeneity. Ensuring the replicability of identified cell clusters across studies is essential for determining their biological robustness. We assess the replicabilit…
View article: Examining the NEUROG2 lineage and associated gene expression in human cortical organoids
Examining the NEUROG2 lineage and associated gene expression in human cortical organoids Open
Proneural genes are conserved drivers of neurogenesis across the animal kingdom. How their functions have adapted to guide human-specific neurodevelopmental features is poorly understood. Here, we mined transcriptomic data from human fetal…
View article: Solanum pan-genomics and pan-genetics reveal paralogs as contingencies in crop engineering
Solanum pan-genomics and pan-genetics reveal paralogs as contingencies in crop engineering Open
Pan-genomics and genome editing technologies are revolutionizing the breeding of globally cultivated crops. A transformative opportunity lies in the reciprocal exchange of genotype-to-phenotype knowledge of agricultural traits between thes…
View article: Defining Transcriptomic Heterogeneity between Left and Right Ventricle-Derived Cardiac Fibroblasts
Defining Transcriptomic Heterogeneity between Left and Right Ventricle-Derived Cardiac Fibroblasts Open
Cardiac fibrosis is a key aspect of heart failure, leading to reduced ventricular compliance and impaired electrical conduction in the myocardium. Various pathophysiologic conditions can lead to fibrosis in the left ventricle (LV) and/or r…
View article: Comparative transcriptomics reveals human-specific cortical features
Comparative transcriptomics reveals human-specific cortical features Open
The cognitive abilities of humans are distinctive among primates, but their molecular and cellular substrates are poorly understood. We used comparative single-nucleus transcriptomics to analyze samples of the middle temporal gyrus (MTG) f…
View article: Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution
Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution Open
Enhanced cognitive function in humans is hypothesized to result from cortical expansion and increased cellular diversity. However, the mechanisms that drive these phenotypic innovations remain poorly understood, in part because of the lack…
View article: Supplementary Tables for "Comparative single cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution"
Supplementary Tables for "Comparative single cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution" Open
Supplementary Tables to reproduce results reported in "Comparative single cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution"
View article: Conserved coexpression at single cell resolution across primate brains
Conserved coexpression at single cell resolution across primate brains Open
Enhanced cognitive function in humans is hypothesized to result from cortical expansion and increased cellular diversity. However, the mechanisms that drive these phenotypic differences remain poorly understood, in part due to the lack of …
View article: Comparative transcriptomics reveals human-specific cortical features
Comparative transcriptomics reveals human-specific cortical features Open
Humans have unique cognitive abilities among primates, including language, but their molecular, cellular, and circuit substrates are poorly understood. We used comparative single nucleus transcriptomics in adult humans, chimpanzees, gorill…
View article: Coexpression reveals conserved gene programs that co-vary with cell type across kingdoms
Coexpression reveals conserved gene programs that co-vary with cell type across kingdoms Open
What makes a mouse a mouse, and not a hamster? Differences in gene regulation between the two organisms play a critical role. Comparative analysis of gene coexpression networks provides a general framework for investigating the evolution o…
View article: Coexpression reveals conserved mechanisms of transcriptional cell identity
Coexpression reveals conserved mechanisms of transcriptional cell identity Open
What makes a mouse a mouse, and not a hamster? The answer lies in the genome, and more specifically, in differences in gene regulation between the two organisms: where and when each gene is expressed. To quantify differences, a typical stu…
View article: Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato Open
View article: Free-energy-based framework for early forecasting of stem cell differentiation.
Free-energy-based framework for early forecasting of stem cell differentiation. Open
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the differentiation o…
View article: Free-energy-based framework for early forecasting of stem cell differentiation
Free-energy-based framework for early forecasting of stem cell differentiation Open
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here, we develop an integrated stochastic modelling framework for predicting the differentiation o…
View article: Homeostatic mechanics framework for modelling interactions of cells with the microenvironment
Homeostatic mechanics framework for modelling interactions of cells with the microenvironment Open
Spreading and locomotion enable the cells to explore their microenvironments during the interphase period of the cell cycle (24-48 hours after cell seeding and prior to cell division). The morphologies adopted by cells in this period dicta…
View article: Free-energy-based framework for early forecasting of stem cell differentiation
Free-energy-based framework for early forecasting of stem cell differentiation Open
Commitment of stem cells to different lineages is inherently stochastic but regulated by a range of environmental bio/chemo/mechanical cues. Here we develop an integrated stochastic modelling framework for predicting the differentiation of…
View article: Entropic Forces Drive Cellular Contact Guidance
Entropic Forces Drive Cellular Contact Guidance Open
View article: Entropic forces drive cellular contact guidance
Entropic forces drive cellular contact guidance Open
Contact guidance—the widely-known phenomenon of cell alignment induced by anisotropic environmental features—is an essential step in the organization of adherent cells, but the mechanisms by which cells achieve this orientational ordering …