Han Bit Baek
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View article: ERK activation dynamics in maturing oocyte controls embryonic nuclear divisions in Caenorhabditis elegans
ERK activation dynamics in maturing oocyte controls embryonic nuclear divisions in Caenorhabditis elegans Open
ERK activity oscillates between sustained activation during oocyte formation and transient inactivation during oocyte maturation, fertilization, and early embryogenesis. Consequences of ectopic ERK activity upon oocyte maturation and in ea…
View article: Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells
Androgen receptor-dependent regulation of metabolism in high grade bladder cancer cells Open
The observed sex disparity in bladder cancer (BlCa) argues that androgen receptor (AR) signaling has a role in these malignancies. BlCas express full-length AR (FL-AR), constitutively active AR splice variants, including AR-v19, or both, a…
View article: Depletion of androgen receptor low molecular weight isoform reduces bladder tumor cell viability and induces apoptosis
Depletion of androgen receptor low molecular weight isoform reduces bladder tumor cell viability and induces apoptosis Open
View article: The p14ARF tumor suppressor restrains androgen receptor activity and prevents apoptosis in prostate cancer cells
The p14ARF tumor suppressor restrains androgen receptor activity and prevents apoptosis in prostate cancer cells Open
View article: XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies
XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies Open
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy…