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View article: Society for Cardiovascular Magnetic Resonance 2023 Cases of SCMR case series
Society for Cardiovascular Magnetic Resonance 2023 Cases of SCMR case series Open
"Cases of SCMR" is a case series on the SCMR website (https://www.scmr.org) for the purpose of education. The cases reflect the clinical presentation and the use of cardiovascular magnetic resonance in the diagnosis and management of cardi…
View article: Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial
Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial Open
Background: Transcutaneous afferent patterned stimulation (TAPS) is a wrist-worn, non-invasive therapy delivering calibrated stimulation to the median and radial nerves. While the efficacy and safety of TAPS therapy for essential tremor (E…
View article: Hyperacute Prediction of Targeted Temperature Management Outcome After Cardiac Arrest
Hyperacute Prediction of Targeted Temperature Management Outcome After Cardiac Arrest Open
A bstract Introduction Targeted temperature management (TTM) has been associated with greater likelihood of neurological recovery among comatose survivors of cardiac arrest. However, the efficacy of TTM is not consistently observed, possib…
View article: Unsupervised Machine Learning Unveil Easily Identifiable Subphenotypes of COVID-19 With Differing Disease Trajectories
Unsupervised Machine Learning Unveil Easily Identifiable Subphenotypes of COVID-19 With Differing Disease Trajectories Open
Background Given the clinical heterogeneity of COVID-19 infection, we hypothesize the existence of subphenotypes based on early inflammatory responses that are associated with mortality and additional complications. Methods For this cross-…
View article: Predicting respiratory decompensation in mechanically ventilated adult ICU patients
Predicting respiratory decompensation in mechanically ventilated adult ICU patients Open
Introduction: Mechanical ventilation is a life-saving treatment in the Intensive Care Unit (ICU), but often causes patients to be at risk of further respiratory complication. We created a statistical model utilizing electronic health recor…
View article: Data from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Data from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence of a tumor anti…
View article: Fig S4 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S4 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Effect of LB-1 in tumor model without MSLN expression
View article: Data from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Data from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Agonistic CD40 monoclonal antibodies (mAb) have demonstrated some clinical activity, but with dose-limiting toxicity. To reduce systemic toxicity, we developed a bispecific molecule that was maximally active in the presence of a tumor anti…
View article: Fig S2 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S2 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Soluble and cell surface expressed MSLN in 4T1-MSLN model and combination treatment with anti-CD40 and anti-MSLN
View article: Fig S5 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S5 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
PC3 cells stably expressing different levels of MSLN
View article: Fig S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Binding and ADCC function of ABBV-428
View article: Fig S4 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S4 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Effect of LB-1 in tumor model without MSLN expression
View article: Fig S5 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S5 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
PC3 cells stably expressing different levels of MSLN
View article: Fig S3 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S3 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Liver inflammation and macrophage activation by LB-1
View article: Table S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Table S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Binding affinity of LB-1
View article: Table S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Table S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Binding affinity of LB-1
View article: Fig S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S1 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Binding and ADCC function of ABBV-428
View article: Fig S2 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S2 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Soluble and cell surface expressed MSLN in 4T1-MSLN model and combination treatment with anti-CD40 and anti-MSLN
View article: Fig S3 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity
Fig S3 from A Bispecific Molecule Targeting CD40 and Tumor Antigen Mesothelin Enhances Tumor-Specific Immunity Open
Liver inflammation and macrophage activation by LB-1
View article: High expression of LY6E is an independent prognostic factor of colorectal cancer patients
High expression of LY6E is an independent prognostic factor of colorectal cancer patients Open
Colorectal cancer (CRC) is common cancer worldwide, and the 5‑year relative survival rate of CRC patients with distant metastasis is as low as 14%. Therefore, identifying markers of CRC is important for the early detection of CRC and apply…
View article: Predicting Intensive Care Delirium with Machine Learning: Model Development and External Validation
Predicting Intensive Care Delirium with Machine Learning: Model Development and External Validation Open
Background Delirium poses significant risks to patients, but countermeasures can be taken to mitigate negative outcomes. Accurately forecasting delirium in intensive care unit (ICU) patients could guide proactive intervention. Our primary …
View article: Undiagnosed Atrial Septal Defect in the Setting of Comorbidities and Ventricular Failure: Seemingly Simple Disease with a Challenging Diagnosis
Undiagnosed Atrial Septal Defect in the Setting of Comorbidities and Ventricular Failure: Seemingly Simple Disease with a Challenging Diagnosis Open
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View article: ODP405 Effects of Gonadotrope-Specific Knockout of Creb on HPG Axis Function in Mice
ODP405 Effects of Gonadotrope-Specific Knockout of Creb on HPG Axis Function in Mice Open
Background and Objective Reproduction is regulated by FSH and LH, which are synthesized and secreted by pituitary gonadotropes in response to pulsatile hypothalamic GnRH in a frequency dependent manner. Low and high GnRH pulse frequencies …
View article: A Method to Explore Variations of Ventilator-Associated Event Surveillance Definitions in Large Critical Care Databases in the United States
A Method to Explore Variations of Ventilator-Associated Event Surveillance Definitions in Large Critical Care Databases in the United States Open
OBJECTIVES: The Centers for Disease Control has well-established surveillance programs to monitor preventable conditions in patients supported by mechanical ventilation (MV). The aim of the study was to develop a data-driven methodology to…
View article: Bilateral papilledema with vision loss due to post–COVID-19–induced thiamine deficiency: illustrative case
Bilateral papilledema with vision loss due to post–COVID-19–induced thiamine deficiency: illustrative case Open
BACKGROUND Bilateral papilledema with vision loss is considered a neurosurgical emergency due to high intracranial pressure. However, it may not be the only cause of papilledema. The authors reported an association among coronavirus diseas…
View article: An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy
An anti-PD-1–GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy Open
Costimulatory receptors such as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) play key roles in regulating the effector functions of T cells. In human clinical trials, however, GITR agonist antibodies have sh…