Han Jo Kim
YOU?
Author Swipe
View article: <scp>c‐Abl</scp> Kinase Targets Tight Junction Protein <scp>ZO</scp> ‐2 in Regulation of Cell Migration and Morphology
<span>c‐Abl</span> Kinase Targets Tight Junction Protein <span>ZO</span> ‐2 in Regulation of Cell Migration and Morphology Open
c‐Abl is a non‐receptor tyrosine kinase involved in the regulation of cell migration and morphogenesis, but the underlying mechanism remains unclear. Here, we report the identification of tight junction protein ZO‐2 as a bona fide substrat…
View article: Rethinking I/O Caching for Large Language Model Inference on Resource-Constrained Mobile Platforms
Rethinking I/O Caching for Large Language Model Inference on Resource-Constrained Mobile Platforms Open
Large language models (LLMs) have traditionally relegated inference to remote servers, leaving mobile devices as thin clients. Recently, advances in mobile GPUs and NPUs have made on-device inference increasingly feasible, particularly for…
View article: Impact of Complications on DRG Assignment for Adult Spinal Deformity Surgery Using the ISSG-AO Classification System
Impact of Complications on DRG Assignment for Adult Spinal Deformity Surgery Using the ISSG-AO Classification System Open
Study Design. Retrospective cohort Objective. The ISSG-AO Spinal Deformity Complication Classification System (SDCCS) predicts Diagnosis Related Group (DRG) coding and cost. Background. Inconsistent definitions of complications contribute …
View article: Intersection of Black race and carbohydrate antigen 19‐9 nonproduction underpins worse pathologic response to neoadjuvant therapy in pancreatic cancer
Intersection of Black race and carbohydrate antigen 19‐9 nonproduction underpins worse pathologic response to neoadjuvant therapy in pancreatic cancer Open
Background Black patients with pancreatic ductal adenocarcinoma (PDAC) are less likely to have a major pathologic response (MPR) after neoadjuvant chemotherapy (NAC). Data suggest lower baseline carbohydrate antigen 19‐9 (CA 19‐9) among Bl…
View article: Could Spinal Cord-Canal Mismatch Compromise Clinical Success of Cervical Disc Replacement in Cervical Myelopathy?
Could Spinal Cord-Canal Mismatch Compromise Clinical Success of Cervical Disc Replacement in Cervical Myelopathy? Open
Study Design Retrospective cohort study. Objective To evaluate whether spinal cord-canal mismatch (SCCM) affects clinical outcomes following cervical disc replacement (CDR) in patients with cervical myelopathy, using patient-reported outco…
View article: Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis
Age and Spinal Level as Predictors of Lumbar Disc Degeneration in Humans and Mice: A Comparative Analysis Open
Background Aging is a major risk factor for IVD degeneration and chronic lower back pain. Comparing degenerative patterns in human and mice, a commonly used pre‐clinical model, is crucial for validating it in preclinical mechanistic resear…
View article: Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Skin Anti-Aging and Moisturizing Effects of Low-Molecular-Weight Collagen Peptide Supplementation in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Open
Skin aging, a multifactorial process influenced by both intrinsic and extrinsic factors, manifests as wrinkles, dryness, reduced elasticity, and altered pore structure. Despite the promising anti-aging effects of low-molecular-weight colla…
View article: Multi-modal virtual reality system for tinnitus treatment methods and validation
Multi-modal virtual reality system for tinnitus treatment methods and validation Open
Virtual reality (VR) has been utilized in clinical treatment because it can efficiently simulate situations that are difficult to control in the real world. In this study, we evaluated the efficacy of VR in patients with chronic subjective…
View article: Carbon Footprint of Minimally Invasive and Open Microdiscectomy: Emerging Implications
Carbon Footprint of Minimally Invasive and Open Microdiscectomy: Emerging Implications Open
Study Design Retrospective cohort study. Objective To quantify and compare the carbon footprint (CF) of open and MIS microdiscectomy. Methods The study included 161 patients undergoing primary 1 level open or minimally invasive surgery (MI…
View article: Age‐related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross‐sectional trajectories and longitudinal validation
Age‐related amyloid beta dynamics modeled with the generalized additive model for location, scale, and shape (GAMLSS) across diverse populations: Cross‐sectional trajectories and longitudinal validation Open
INTRODUCTION We developed and validated age‐related amyloid beta (Aβ) positron emission tomography (PET) trajectories using a statistical model in cognitively unimpaired (CU) individuals. METHODS We analyzed 849 CU Korean and 521 CU non‐Hi…
View article: Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress
Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress Open
Background: Lysosomal dysfunction could be an underlying cause of Alzheimer's disease, with Tau oligomer being an important inducer or amplifier of lysosomal stress associated with the disease. Tau oligomer is a well-known substrate of aut…
View article: ACE inhibition increases Alzheimer's disease risk by promoting tau phosphorylation
ACE inhibition increases Alzheimer's disease risk by promoting tau phosphorylation Open
Reportedly, over 60% of individuals in the USA aged 65 or older take antihypertensive medications, making it crucial to evaluate their potential impact on dementia. Alzheimers disease (AD), the most prevalent form of dementia, develops ins…
View article: Intraoperative Laryngeal Nerve Monitoring During Thyroidectomy: Survey for the Current Practices and Patterns of the Korean Society of Head and Neck Surgery
Intraoperative Laryngeal Nerve Monitoring During Thyroidectomy: Survey for the Current Practices and Patterns of the Korean Society of Head and Neck Surgery Open
Background and Objectives Intraoperative laryngeal nerve monitoring (IOLNM) is increasingly utilized during thyroidectomy to prevent recurrent laryngeal nerve (RLN) injuries. However, its use varies considerably depending on surgeon prefer…
View article: Innovation through individual-focused transformational leadership in China: mediation by leader identification and cross-level moderation by team-focused leadership and innovation climate
Innovation through individual-focused transformational leadership in China: mediation by leader identification and cross-level moderation by team-focused leadership and innovation climate Open
In the new phase of economic transformation and social development, innovation has emerged as a critical issue. Corporate innovation largely depends on the innovative behavior of its members, making it crucial to understand the impact of t…
View article: HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease
HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease Open
Circulating blood factors are critical for homeostasis of the adult ventricular-subventricular (V-SVZ) and subgranular zones, which contain neural stem cells (NSCs) crucial for sustained neurogenesis. Circulating sphingosine-1-phosphate (S…
View article: Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance
Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance Open
INTRODUCTION Frontotemporal dementia (FTD) with right anterior temporal lobe (rATL) predominance lacks universally agreed‐upon diagnostic criteria. This study validated the Amsterdam diagnostic tree (ADT) for right temporal variant FTD (rt…
View article: Myofibroblastic cancer‐associated fibroblast subtype heterogeneity in pancreatic cancer
Myofibroblastic cancer‐associated fibroblast subtype heterogeneity in pancreatic cancer Open
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a fibrotic stroma that has both tumor-promoting and tumor-restraining properties. Different types of cancer-associated fibroblasts (CAFs) have been described. Here, we investigated wh…
View article: Toxicity of Consecutive Treatments Combining Synthetic and Organic Miticides to Nurse Bees of Apis mellifera
Toxicity of Consecutive Treatments Combining Synthetic and Organic Miticides to Nurse Bees of Apis mellifera Open
Varroa destructor, an ectoparasitic mite of honey bees, is a major contributor to global colony declines. To manage infestations, beekeepers frequently apply both synthetic and organic miticides—sometimes in combination. While much attenti…
View article: Tumor-intrinsic and Cancer-associated Fibroblast Subtypes Independently Predict Outcomes in Pancreatic Cancer.
Tumor-intrinsic and Cancer-associated Fibroblast Subtypes Independently Predict Outcomes in Pancreatic Cancer. Open
OBJECTIVE: To assess the utility of tumor-intrinsic and cancer-associated fibroblast (CAF) subtypes of pancreatic ductal adenocarcinoma (PDAC) in predicting response to neoadjuvant therapy (NAT) and overall survival. BACKGROUND: PDAC remai…
View article: Impact of thoracolumbar inflection point on outcomes and complications in adult spinal deformity
Impact of thoracolumbar inflection point on outcomes and complications in adult spinal deformity Open
OBJECTIVE Existing literature on the impact of alignment parameters relative to the thoracolumbar inflection point remains sparse. The authors aimed to investigate the influence of the inflection point, lumbar lordosis apex (LLA), and othe…
View article: Nationwide real-world practice pattern and clinical data of palbociclib in HR (+), HER2 (−) metastatic breast cancer patients in Korea (KCSG BR21-15)
Nationwide real-world practice pattern and clinical data of palbociclib in HR (+), HER2 (−) metastatic breast cancer patients in Korea (KCSG BR21-15) Open
This is the largest country-based real-world study on palbociclib + letrozole in Asia. Palbociclib demonstrated median rwOS over 60 months, comparable to other pivotal trials.
View article: From Social to Financial: Understanding Trust in Extended Payment Services on Social Networking Platforms
From Social to Financial: Understanding Trust in Extended Payment Services on Social Networking Platforms Open
Considering the rapid increase in mobile payment usage, numerous big tech companies have added mobile payment to the primary services that their platforms offer. However, extant research predominantly treats this added service as a standal…
View article: Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study
Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study Open
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by NOTCH3 mutations. While CADASIL affects both sexes, differences in clinical pres…
View article: Guidelines for the Treatment of Laryngeal Cancer from the Korean Society of Head and Neck Surgery
Guidelines for the Treatment of Laryngeal Cancer from the Korean Society of Head and Neck Surgery Open
Objectives. Effective treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation of essential functions, such as voice and swallowing. This study, led by the Clinical Practice Guid…
View article: Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition
Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition Open
GWAS of Alzheimer's disease have been predominantly based on European ancestry cohorts with clinically diagnosed patients. Increasing the ancestral diversity of GWAS and focusing on imaging brain biomarkers for Alzheimer's disease may lead…
View article: Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition Open
Importance Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. Objective To investigate the associations among …
View article: Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker‐guided diagnostics
Differential roles of Alzheimer's disease plasma biomarkers in stepwise biomarker‐guided diagnostics Open
INTRODUCTION This study aimed to investigate the differential roles of various plasma biomarkers in a stepwise diagnostic strategy for Alzheimer's disease (AD). METHODS A total of 2984 participants, including 666 cognitively unimpaired (CU…