Yaling Han
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View article: Differential prognostic value of high-sensitivity troponin T based on renal function status: insights from 14,208 ACS patients undergoing PCI
Differential prognostic value of high-sensitivity troponin T based on renal function status: insights from 14,208 ACS patients undergoing PCI Open
Background and objectives High-sensitivity troponin T (hsTnT) is a standard biomarker for myocardial injury detection, but its prognostic value may differ by renal function status. This study evaluated how renal function modifies the progn…
View article: Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence
Potential effect of FLASH radiotherapy on testicular damage: a review of current evidence Open
Radiotherapy is a major source of ionizing radiation that adversely affects the male reproductive system. FLASH radiotherapy (FLASH-RT), a novel technique delivering ultra-high dose rate (UHDR) radiation, has shown promise in reducing norm…
View article: Comparison of clopidogrel monotherapy versus prolonged DAPT based on the GRACE risk score in patients with acute coronary syndromes at high ischemic and bleeding risk: a subgroup analysis of the OPT-BIRISK randomized clinical trial
Comparison of clopidogrel monotherapy versus prolonged DAPT based on the GRACE risk score in patients with acute coronary syndromes at high ischemic and bleeding risk: a subgroup analysis of the OPT-BIRISK randomized clinical trial Open
Among birisk patients with ACS, clopidogrel monotherapy was associated with lower incidence of all bleeding events (BARC 1-5) versus extended DAPT regardless of GRACE score, but showed no significant difference in BARC 2, 3, or 5 bleeding.…
View article: Integrated network toxicology, machine learning, molecular docking and experimental validation to elucidate mechanism of polyethylene terephthalate microplastics inducing periodontitis
Integrated network toxicology, machine learning, molecular docking and experimental validation to elucidate mechanism of polyethylene terephthalate microplastics inducing periodontitis Open
Growing evidence highlights the health risks of micro-plastics (MPs) exposure, with reported accumulations in enclosed anatomical sites such as the heart, placenta, and circulatory system. However, the role of MPs in periodontitis remains …
View article: Novel Miniature Mobile Integrated Operating Cabin-Theatre: A Clinical Application
Novel Miniature Mobile Integrated Operating Cabin-Theatre: A Clinical Application Open
Objective: This study aimed to investigate the feasibility, efficacy, and safety of using a miniature mobile integrated cabin-theatre equipped with angiography and surgical operating room capabilities, and to explore its therapeutic scope,…
View article: Efficacy and safety of clopidogrel and ticagrelor in acute coronary syndrome patients with CYP2C19 loss-of-function alleles after percutaneous coronary intervention: based on the Global Registry of Acute Coronary Events score
Efficacy and safety of clopidogrel and ticagrelor in acute coronary syndrome patients with CYP2C19 loss-of-function alleles after percutaneous coronary intervention: based on the Global Registry of Acute Coronary Events score Open
These real-world data on East Asian patients with CYP2C19 LOF alleles suggest that GRACE risk stratification may help differentiate ischemic and bleeding risks post-PCI.
View article: Single-cell and spatial transcriptomic analyses reveals the dynamic transcript profiles of myocardial lymphangiogenesis post-myocardial infarction
Single-cell and spatial transcriptomic analyses reveals the dynamic transcript profiles of myocardial lymphangiogenesis post-myocardial infarction Open
Background: Cardiac lymphatics play an important role in myocardial edema and inflammation, however, the heterogeneity of cardiac lymphatic endothelial cells (LECs) and their biological functions have rarely been investigated. Methods: Thi…
View article: Plasma microRNA-210 is associated with VEGF-A and EphrinA3 and relates to coronary collateral circulation in patients with coronary heart disease: a cross-sectional study
Plasma microRNA-210 is associated with VEGF-A and EphrinA3 and relates to coronary collateral circulation in patients with coronary heart disease: a cross-sectional study Open
Background This study explored the interrelationships among vascular endothelial growth factor A (VEGF-A), microRNA-210 (miR-210), and EphrinA3 in the plasma of patients with coronary heart disease (CHD), and their collective influence on …
View article: Analysis of inter-hospital transfer on clinical outcomes after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A secondary analysis of the BRIGHT-4 trial
Analysis of inter-hospital transfer on clinical outcomes after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A secondary analysis of the BRIGHT-4 trial Open
Background Previous studies evaluating the influence of inter-hospital transfer on mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) reported conflicting re…
View article: Temporal dynamics of the multi-omic response reveals the modulation of macrophage subsets post-myocardial infarction
Temporal dynamics of the multi-omic response reveals the modulation of macrophage subsets post-myocardial infarction Open
By integrating scRNAseq and proteomics data, this study provides a comprehensive overview of heterogeneity and dynamic protein level changes of macrophages post-MI, and characterizes the PTMs in macrophages, and lays the groundwork for dev…
View article: The systemic inflammatory response index as a risk factor for all-cause and cardiovascular mortality among individuals with coronary artery disease: evidence from the cohort study of NHANES 1999–2018
The systemic inflammatory response index as a risk factor for all-cause and cardiovascular mortality among individuals with coronary artery disease: evidence from the cohort study of NHANES 1999–2018 Open
SIRI was independently associated with all-cause and CVD mortality, and the dose-response relationship was J-shaped. SIRI might serve as a valid predictor for all-cause and CVD mortality both in the short and long terms.
View article: A National Registry to Improve the Quality of Care for Patients With Acute Coronary Syndrome and Diabetes: Protocol for the China Diabetes Cardiovascular (CDCV) Project
A National Registry to Improve the Quality of Care for Patients With Acute Coronary Syndrome and Diabetes: Protocol for the China Diabetes Cardiovascular (CDCV) Project Open
Evidence-based treatment strategies for patients with cardiovascular disease and diabetes have been updated in recent years. However, substantial gaps remain between guideline recommendations and clinical practice, which justify the urgent…
View article: Effectiveness of clopidogrel vs. ticagrelor based on the ABCD-GENE score in acute coronary syndrome patients following percutaneous coronary intervention
Effectiveness of clopidogrel vs. ticagrelor based on the ABCD-GENE score in acute coronary syndrome patients following percutaneous coronary intervention Open
Aim This study employs the ABCD-GENE score (age, body mass index, chronic kidney disease, diabetes, and CYP2C19 variants) to compare the effectiveness and safety of clopidogrel versus ticagrelor-based DAPT in ACS patients post-PCI. Methods…
View article: Association of high-sensitivity C-reactive protein to albumin ratio with all-cause and cardiac death in coronary heart disease individuals: A retrospective NHANES study
Association of high-sensitivity C-reactive protein to albumin ratio with all-cause and cardiac death in coronary heart disease individuals: A retrospective NHANES study Open
Background This research aimed to explore the association of high-sensitivity C-reactive protein to albumin ratio (CAR) with death events in community-based patients with coronary heart disease (CHD). Methods 624 CHD participants were foll…
View article: Intramyocardial Hematoma After Percutaneous Coronary Intervention for Chronic Total Occlusion: Two Case Reports
Intramyocardial Hematoma After Percutaneous Coronary Intervention for Chronic Total Occlusion: Two Case Reports Open
Percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) is an extremely challenging procedure, with intramyocardial hematoma (IMH) being one of its rare yet severe complications. In this report, we detail two cases of IM…
View article: HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells
HINT1 aggravates aortic aneurysm by targeting ITGA6/FAK axis in vascular smooth muscle cells Open
Aortic aneurysm is a high-risk cardiovascular disease without an effective cure. Vascular smooth muscle cell (VSMC) phenotypic switching is a key step in the pathogenesis of aortic aneurysm. Here, we revealed the role of histidine triad nu…
View article: Thin floor milling using moving air jet support with controllable flow direction
Thin floor milling using moving air jet support with controllable flow direction Open
Overcut or poor surface quality will easily during thin floor milling due to its low rigidity. Machining with the assistance of mobile support device is an important and frontier manufacturing method for milling the thin floor of a pocket …
View article: A Segmented Autoregressive Model Based on the Horizontal and Vertical Axes
A Segmented Autoregressive Model Based on the Horizontal and Vertical Axes Open
This paper aims to further discuss the segmentation and estimation issues of autoregressive (AR) models. The innovations in the AR model do not follow the default normal distribution but rather an arbitrary distribution or a mixture of sev…
View article: CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis
CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis Open
Adipose‐derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self‐renewal capacity and easy accessibility. However, their limited osteogenic potential remains a critical challenge for clinical applica…
View article: Correction to: Association Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome Who Have Quit Smoking: Study Design of a Prospective Cohort Study
Correction to: Association Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome Who Have Quit Smoking: Study Design of a Prospective Cohort Study Open
[This corrects the article DOI: 10.1097/CD9.0000000000000139.].
View article: <scp><i>GABARAPL1</i></scp> Exerts Regulatory Effects on Hypoxia‐Induced Pyroptosis in the Pathogenesis of Myocardial Infarction
<span><i>GABARAPL1</i></span> Exerts Regulatory Effects on Hypoxia‐Induced Pyroptosis in the Pathogenesis of Myocardial Infarction Open
Myocardial infarction (MI) is a major health threat, with high incidence and poor prognosis. This study aims to discover novel biomarkers and therapeutic targets to reduce myocardial damage and improve patient survival. A comprehensive bio…