Han Petry
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View article: Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin
Contribution of the second transmembrane helix of the secretin receptor to the positioning of secretin Open
The secretin amino‐terminal residues are essential for high affinity binding to its cognate receptor and for its biological activity. Mutation of the [Asp 3 ] residue of secretin to [Asn 3 ] decreased the ligand's affinity for the rat wild…