Huakang Tu
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View article: Mucin phenotype-based deep learning framework for intestinal metaplasia-carcinogenesis progression prediction
Mucin phenotype-based deep learning framework for intestinal metaplasia-carcinogenesis progression prediction Open
This study decodes spatiotemporal mucin dynamics in gastric carcinogenesis, revealing gastric-type markers (MUC5AC/MUC6) decline progressively while intestinal-type markers (MUC2/CD10) peak in gastric intestinal metaplasia (GIM) before dec…
View article: Trajectories of perioperative serum CEA and non-small cell lung cancer prognosis: a retrospective longitudinal cohort study
Trajectories of perioperative serum CEA and non-small cell lung cancer prognosis: a retrospective longitudinal cohort study Open
Background The role of postoperative carcinoembryonic antigen (CEA) levels in non-small lung cancer (NSCLC) prognostic evaluation remains unclear. Additionally, the dynamic changes in CEA levels during the perioperative period have not bee…
View article: Soluble immune checkpoint factors reveal high-risk osteosarcoma subtypes and enable early metastasis prediction
Soluble immune checkpoint factors reveal high-risk osteosarcoma subtypes and enable early metastasis prediction Open
Background Osteosarcoma is a rare disease, yet it is the most frequent primary malignant bone tumor, with poor survival in metastatic cases. Current PD-1 and PD-L1 checkpoint inhibitors show limited efficacy in osteosarcoma, necessitating …
View article: Artificial Intelligence in digital pathology of breast cancer, new era of practice?
Artificial Intelligence in digital pathology of breast cancer, new era of practice? Open
Breast cancer is the most common cancers among women worldwide. Early diagnosis and personalized medicine are crucial for the treatment of breast cancer. With the development of computer science and the emergence of whole slide imaging tec…
View article: Improving Lung Cancer Risk Prediction Using Machine Learning: A Comparative Analysis of Stacking Models and Traditional Approaches
Improving Lung Cancer Risk Prediction Using Machine Learning: A Comparative Analysis of Stacking Models and Traditional Approaches Open
Background: Lung cancer is a leading cause of cancer-related mortality worldwide, often diagnosed in advanced stages, making early detection critical. This study aimed to evaluate the performance of various machine learning models in predi…
View article: Chinese visceral adiposity index outperforms other obesity indexes in association with increased overall cancer incidence: findings from prospective MJ cohort study
Chinese visceral adiposity index outperforms other obesity indexes in association with increased overall cancer incidence: findings from prospective MJ cohort study Open
Background We assessed the associations of visceral adiposity indexes such as Chinese Visceral Adiposity Index (CVAI), Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), waist circumference (WC), and waist-hip ratio (WHR) wi…
View article: Comparing the efficacy and safety of thromboprophylaxis with enoxaparin <i>versus</i> normal saline after liver transplantation: randomized clinical trial
Comparing the efficacy and safety of thromboprophylaxis with enoxaparin <i>versus</i> normal saline after liver transplantation: randomized clinical trial Open
Background Venous thrombosis represents a significant complication after deceased-donor liver transplantation, yet there are currently no established protocols for thromboprophylaxis after deceased-donor liver transplantation. The aim of t…
View article: Revisiting real-world data studies: Progress, value, and challenges
Revisiting real-world data studies: Progress, value, and challenges Open
This review highlights the indispensable role of real-world data studies (RWS) in complementing randomized controlled trials by generating real-world evidence (RWE) that reflects diverse patient populations and clinical settings. It explor…
View article: Genetic-informed alternative RNA splicing serves an essential role in carcinogenesis and prognosis of non-small-cell lung cancer
Genetic-informed alternative RNA splicing serves an essential role in carcinogenesis and prognosis of non-small-cell lung cancer Open
Dysregulated RNA splicing is a post-transcriptional molecular feature that significantly influences tumor progression and prognosis. However, the role of alternative splicing in the development of non-small cell lung cancer (NSCLC) within …
View article: Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort
Association of the systemic inflammation and anthropometric measurements with cancer risk: a prospective study in MJ cohort Open
Objective To investigate the specific role of inflammation in the connection between obesity and the overall incidence of cancer. Methods A total of 356,554 participants in MJ cohort study were included. Systemic inflammation markers from …
View article: Predicting oral and esophageal cancers by one model in a Chinese prospective cohort study
Predicting oral and esophageal cancers by one model in a Chinese prospective cohort study Open
This study identified the twelve most significant common risk factors for oral and esophageal cancers and developed a single prediction model that performs well for both types of cancer.
View article: Novel machine learning algorithm in risk prediction model for pan-cancer risk: application in a large prospective cohort
Novel machine learning algorithm in risk prediction model for pan-cancer risk: application in a large prospective cohort Open
Objective To develop and validate machine-learning models that predict the risk of pan-cancer incidence using demographic, questionnaire and routine health check-up data in a large Asian population. Methods and analysis This study is a pro…
View article: A biological age model based on physical examination data to predict mortality in a Chinese population
A biological age model based on physical examination data to predict mortality in a Chinese population Open
Biological age could be reflective of an individual's health status and aging degree. Limited estimations of biological aging based on physical examination data in the Chinese population have been developed to quantify the rate of aging. W…
View article: Combining Classic and Novel Neutrophil-Related Biomarkers to Identify Non-Small-Cell Lung Cancer
Combining Classic and Novel Neutrophil-Related Biomarkers to Identify Non-Small-Cell Lung Cancer Open
Background: Recent studies have revealed that neutrophils play a crucial role in cancer progression. This study aimed to explore the diagnostic value of neutrophil-related biomarkers for non-small-cell lung cancer (NSCLC). Methods: We init…
View article: Association of fat mass and fat‐free mass with all‐cause and cause‐specific mortality in <scp>Asian individuals</scp>: A prospective cohort study
Association of fat mass and fat‐free mass with all‐cause and cause‐specific mortality in <span>Asian individuals</span>: A prospective cohort study Open
Objective The study's objective was to investigate the association of fat mass index (FMI) and fat‐free mass index (FFMI) with all‐cause mortality and cause‐specific mortality in the Chinese population. Methods A total of 422,430 participa…
View article: Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort
Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort Open
Background Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as a better biomarker of aging than chronological age, and plant-based dietary patte…
View article: 6-Year trajectory of fasting plasma glucose (FPG) and mortality risk among individuals with normal FPG at baseline: a prospective cohort study
6-Year trajectory of fasting plasma glucose (FPG) and mortality risk among individuals with normal FPG at baseline: a prospective cohort study Open
Background Higher fasting plasma glucose (FPG) levels were associated with an increased risk of all-cause mortality; however, the associations between long-term FPG trajectory groups and mortality were unclear, especially among individuals…
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
Supplementary Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
View article: Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers
Data from Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers Open
The RAS family of small GTPases represents the most commonly activated oncogenes in human cancers. To better understand the prevalence of somatic RAS mutations and the compendium of genes that are coaltered in RAS-mutant tumors, we analyze…