Han Zuilhof
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View article: A modular platform for surface-bound biosensing: SpyCatcher-Mediated functionalization of antifouling polypeptide brushes on gold and polystyrene
A modular platform for surface-bound biosensing: SpyCatcher-Mediated functionalization of antifouling polypeptide brushes on gold and polystyrene Open
Precise molecular engineering of surfaces is critical for advancing biosensing, antifouling technologies, and smart material interfaces, yet current methods often suffer from uncontrolled orientation or require complex surface chemical mod…
View article: Bioinspired TriPhase Interfacial Design Promotes Mass Transfer for Enhanced Photocatalytic Nitrogen Fixation
Bioinspired TriPhase Interfacial Design Promotes Mass Transfer for Enhanced Photocatalytic Nitrogen Fixation Open
View article: CCDC 2385666: Experimental Crystal Structure Determination
CCDC 2385666: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of a High-Resolution Tandem Mass Spectral Library for Pyrrolizidine Alkaloids (PASL)
Development of a High-Resolution Tandem Mass Spectral Library for Pyrrolizidine Alkaloids (PASL) Open
View article: Substituent Effects on Sulfur Phenolate Exchange Reactions: Reactivity and Bonding Analysis
Substituent Effects on Sulfur Phenolate Exchange Reactions: Reactivity and Bonding Analysis Open
The Sulfur Phenolate Exchange reaction (SuPhenEx) provides a fluorine‐free alternative S(VI) exchange chemistry by substituting nitrophenolate as the leaving group instead of fluoride (as in SuFEx reactions), offering a synthetically appea…
View article: Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions
Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions Open
The synthesis of sequence‐defined oligomers with a high molecular weight has remained a challenge due to the lack of effective coupling methods, reduced reactivity and/or selectivity with increasing oligomer lengths, and poor solubility of…
View article: Activity Descriptors of Mo2C-based Catalysts for C-OH Bond Activation
Activity Descriptors of Mo2C-based Catalysts for C-OH Bond Activation Open
Deriving structure-activity relationships is crucial for designing efficient catalysts. To aid in this quest, data-driven methods such as machine learning (ML) are emerging. In this work, we incorporate ML tools with accurate density funct…
View article: 2D lamellar membranes with defect-engineered hierarchical channels impart ultrafast and selective dye/salt separation
2D lamellar membranes with defect-engineered hierarchical channels impart ultrafast and selective dye/salt separation Open
View article: SuFEx Reactions When Shaken Not Stirred
SuFEx Reactions When Shaken Not Stirred Open
Click reactions display many of the goals desired for more sustainable chemical conversions. Yet, the solvent used is an often overlooked aspect in determining the environmental impact of reactions. In the current paper, the first mechanoc…
View article: Front Cover: Rationalizing Catalytic Performances of Mo/W‐(Oxy)Carbides for Hydrodeoxygenation Reaction (ChemCatChem 16/2025)
Front Cover: Rationalizing Catalytic Performances of Mo/W‐(Oxy)Carbides for Hydrodeoxygenation Reaction (ChemCatChem 16/2025) Open
View article: Unravelling emergence of chirality in click-chemistry polymers down to the single-chain level
Unravelling emergence of chirality in click-chemistry polymers down to the single-chain level Open
View article: Multimodal S(VI) Exchange Click Reactions Derived from SF<sub>2</sub> Moieties: Comparative Kinetics and Stereochemistry of SuFEx and SuPhenEx Reactions
Multimodal S(VI) Exchange Click Reactions Derived from SF<sub>2</sub> Moieties: Comparative Kinetics and Stereochemistry of SuFEx and SuPhenEx Reactions Open
The reaction mechanism of multimodal SuFEx and SuPhenEx click chemistries was investigated in detail for substitution of both the first and second fluoride or p-nitrophenolate leaving groups in ∼RN = SOF2 and RN = SOF(…
View article: Paper spray and direct mushroom spray mass spectrometry methods for the analysis of psycho-neurological disorder toxins
Paper spray and direct mushroom spray mass spectrometry methods for the analysis of psycho-neurological disorder toxins Open
Fast screening approaches based on paper spray ionization were developed to identify psycho-neurological disorders mushrooms. Directly spraying from mushroom tissue already allowed direct identification of muscarine, psilocin, and ibotenic…
View article: Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins
Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins Open
The antifouling performance of a previously developed triblock protein, B‐M‐E is optimized, that self‐assembles on gold surfaces to form a nonfouling layer by modifying the sequence of its E block. In this protein, B is a gold‐binding doma…
View article: Promoting Organic Nucleation of Diclofenac: Hydrophobic Interfacial Interactions Drive Self-Assembly
Promoting Organic Nucleation of Diclofenac: Hydrophobic Interfacial Interactions Drive Self-Assembly Open
We compare the pH-triggered nucleation of the pharmaceutical diclofenac in bulk solution and at the air-water interface, using a combination of cryo-transmission electron microscopy, surface-specific spectroscopy and microscopy, and molecu…
View article: Functionalized Antifouling Polymer Brushes for Biospecific Surfaces
Functionalized Antifouling Polymer Brushes for Biospecific Surfaces Open
Biosensors have become integrated into our lives. Current technology requires biosensors not only to have high sensitivity but also to have high specificity for one target, while repelling all other molecules and materials in the biologica…
View article: Rationalizing Catalytic Performances of Mo/W‐(Oxy)Carbides for Hydrodeoxygenation Reaction
Rationalizing Catalytic Performances of Mo/W‐(Oxy)Carbides for Hydrodeoxygenation Reaction Open
Hydrodeoxygenation (HDO) reactions are among the most important reactions for the valorization of biomass to value‐added chemicals. Transition metal carbides (TMCs) are promising alternative HDO catalysts to platinum group metals. However,…
View article: Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions
Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions Open
View article: Broad Tuning of Paper Microfluidic Properties by Covalent Surface Modification for Precise Flow Control and Sensing
Broad Tuning of Paper Microfluidic Properties by Covalent Surface Modification for Precise Flow Control and Sensing Open
In an effort to innovate on-site sensing platforms for a wide range of analytes in different matrices, microfluidic paper-based devices (μPADs) are promising candidates to bring the lab to the sample, as they allow passive, capillary-actio…
View article: Mechanochemical Enantiospecific Syntheses of Sulfonimidate Esters and Sulfonimidamides by Various S(VI) Exchange Reactions
Mechanochemical Enantiospecific Syntheses of Sulfonimidate Esters and Sulfonimidamides by Various S(VI) Exchange Reactions Open
Mechanochemical S(VI) exchange reactions are developed on chiral S(VI)–F and S(VI)–Cl centers that are fast, solvent–free, high–yielding, and enantiospecific. This approach is used to synthesize a range of sulfonimidate esters and sulfonim…
View article: SuFEx reactions when shaken not stirred
SuFEx reactions when shaken not stirred Open
Click reactions display many of the goals desired for more sustainable chemical conversions. Yet, the solvent used is an often overlooked aspect in determining the environmental impact of reactions. In the current paper we develop the firs…
View article: Rapid analysis of Δ8-tetrahydrocannabinol, Δ9-tetrahydrocannabinol, and cannabidiol in Δ8-tetrahydrocannabinol edibles by Ag(I) paper spray mass spectrometry after simple extraction
Rapid analysis of Δ8-tetrahydrocannabinol, Δ9-tetrahydrocannabinol, and cannabidiol in Δ8-tetrahydrocannabinol edibles by Ag(I) paper spray mass spectrometry after simple extraction Open
Δ8-Tetrahydrocannabinol (THC) products are increasingly popular despite uncertainties regarding their legality and safety. Based on the hypothesis that unique double-stage tandem mass spectrometry (MS2) and triple-stage tandem m…
View article: Hydrolytic, Thermal, and Electrochemical Stability of Thiol- and Terminal Alkyne-Based Monolayers on Gold: A Comparative Study
Hydrolytic, Thermal, and Electrochemical Stability of Thiol- and Terminal Alkyne-Based Monolayers on Gold: A Comparative Study Open
The terminal alkyne-Au interaction is emerging as a promising adsorbing bonding motif for organic monolayers, allowing it to be used for installing antifouling layers and/or recognition elements on gold surfaces for biosensing applications…
View article: Paper-immobilized liquid-phase microextraction for direct paper spray mass spectrometry and immuno-detection of atropine in baby food, buckwheat cereals, and edible oils at regulatory levels
Paper-immobilized liquid-phase microextraction for direct paper spray mass spectrometry and immuno-detection of atropine in baby food, buckwheat cereals, and edible oils at regulatory levels Open
Our paper-based workflow has the potential to aid in the fast and affordable monitoring of atropine. Importantly, the method's suitability is demonstrated for diverse matrices, and it is expected that it can be easily adapted to monitor fo…
View article: Structural elucidation and long-term stability of synthesized NADES: A detailed physicochemical analysis
Structural elucidation and long-term stability of synthesized NADES: A detailed physicochemical analysis Open
View article: One-step antifouling coating of polystyrene using engineered polypeptides
One-step antifouling coating of polystyrene using engineered polypeptides Open
Unwanted nonspecific adsorption caused by biomolecules influences the lifetime of biomedical devices and the sensing performance of biosensors. Previously, we have designed B-M-E triblock proteins that rapidly assemble on inorganic surface…
View article: Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly
Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly Open
Key finding: the hydrophobic air–water interface promotes organic nucleation of model diclofenac by assembling into highly ordered dimer motifs at the hydrophobic interface, in stark contrast to their dynamically ordered clusters in bulk s…
View article: Temperature–dependent reaction rates of quinone-alkene cycloaddition reveal that only entropy determines the rate of SPOCQ reactions
Temperature–dependent reaction rates of quinone-alkene cycloaddition reveal that only entropy determines the rate of SPOCQ reactions Open
Detailed Eyring analysis of the SPOCQ reaction between a quinone and alkene or alkyne dienophiles quantifies the rate constants and reveals that the high reaction rates originate from preorganization of the dienophiles towards the transiti…
View article: A 2,6-diamidopyridine-based macrocyclic aromatic amide receptor with cascade ion pair recognition
A 2,6-diamidopyridine-based macrocyclic aromatic amide receptor with cascade ion pair recognition Open
Ion-pair receptors constitute an important class of synthetic receptors within the realm of host–guest and supramolecular chemistry.
View article: A Modular Platform for Surface-Bound Biosensing: SpyCatcher-Mediated Functionalization of Antifouling Polypeptide Brushes on Gold and Polystyrene
A Modular Platform for Surface-Bound Biosensing: SpyCatcher-Mediated Functionalization of Antifouling Polypeptide Brushes on Gold and Polystyrene Open