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View article: Neovascular age-related macular degeneration complicated by large submacular hemorrhage managed with faricimab monotherapy
Neovascular age-related macular degeneration complicated by large submacular hemorrhage managed with faricimab monotherapy Open
View article: Biodegradable Adhesive Systems for Bio‐Integrated Applications
Biodegradable Adhesive Systems for Bio‐Integrated Applications Open
Biodegradable adhesives, unlike their traditional counterparts, are engineered to bond to biological tissues while naturally degraded over time, thereby eliminating the need for removal procedures and reducing the risk of chronic inflammat…
View article: P04.03.A LONG READ SEQUENCING IDENTIFIES COMPLEX NF2 STRUCTURAL VARIATION IN MENINGIOMA
P04.03.A LONG READ SEQUENCING IDENTIFIES COMPLEX NF2 STRUCTURAL VARIATION IN MENINGIOMA Open
BACKGROUND Human meningiomas are most commonly driven by biallelic inactivation of the NF2 gene, typically through a combination of NF2 genomic mutation and allelic loss of chromosome 22q. However, approximately 30-40% of individuals with …
View article: Neovascular Age-Related Macular Degeneration Complicated by Large Submacular Hemorrhage Managed with Faricimab Monotherapy
Neovascular Age-Related Macular Degeneration Complicated by Large Submacular Hemorrhage Managed with Faricimab Monotherapy Open
Purpose: To evaluate the visual and anatomic outcomes of intravitreal faricimab monotherapy in neovascular age-related macular degeneration (nAMD) patients presenting with large submacular hemorrhage (SMH). Methods: Patients with neovascul…
View article: Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition
Neural basis of motor symptoms in Alzheimer's disease: role of regional tau burden and cognition Open
INTRODUCTION With accumulating evidence that motor manifestations in Alzheimer's disease (AD) may emerge from AD pathology independent of other copathologies, we investigated the neural basis of motor dysfunction under the amyloid/tau/neur…
View article: Neonatal Outcomes of the Intubation-Surfactant-Extubation versus Less Invasive Surfactant Administration Method: A National Cohort Study in Korea
Neonatal Outcomes of the Intubation-Surfactant-Extubation versus Less Invasive Surfactant Administration Method: A National Cohort Study in Korea Open
Introduction: This study aimed to compare the outcomes of intubation-surfactant-extubation (INSURE) and less invasive surfactant administration (LISA) in very preterm infants with respiratory distress syndrome. Methods: This study included…
View article: Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment
Morphologic and functional alterations in the parasagittal dural space in mild cognitive impairment Open
View article: Stretchable and Biodegradable Thermally Expandable Composites with Microfluidics for On‐Demand and Programmable Destruction of Electronics
Stretchable and Biodegradable Thermally Expandable Composites with Microfluidics for On‐Demand and Programmable Destruction of Electronics Open
The lifespan of the transient electronic system can be determined in advance (i.e., predefined) or controlled via on‐demand and programmable approaches using a diverse range of principles. However, in most cases, dissolution or disappearan…
View article: Attention-deficit/hyperactivity disorder in children with a history of febrile seizures: a systematic review and meta-analysis
Attention-deficit/hyperactivity disorder in children with a history of febrile seizures: a systematic review and meta-analysis Open
View article: Integrating visual assessments and quantification methods for tau PET staging
Integrating visual assessments and quantification methods for tau PET staging Open
INTRODUCTION We compared visual assessments and quantification methods for tau positron emission tomography (PET) staging and evaluated plasma biomarkers and cognitive trajectories across amyloid and tau (AT) staging. METHODS Tau PET scans…
View article: TrialSieve: A Comprehensive Biomedical Information Extraction Framework for PICO, Meta-Analysis, and Drug Repurposing
TrialSieve: A Comprehensive Biomedical Information Extraction Framework for PICO, Meta-Analysis, and Drug Repurposing Open
This work introduces TrialSieve, a novel framework for biomedical information extraction that enhances clinical meta-analysis and drug repurposing. By extending traditional PICO (Patient, Intervention, Comparison, Outcome) methodologies, T…
View article: Adult-onset Neuronal Intranuclear Inclusion Disease Presenting with Intermittent Visual Disturbances and Right Hemiparesis: Clinical Significance and Diagnostic Approach
Adult-onset Neuronal Intranuclear Inclusion Disease Presenting with Intermittent Visual Disturbances and Right Hemiparesis: Clinical Significance and Diagnostic Approach Open
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder characterized by the presence of eosinophilic nuclear inclusions in neurons and somatic cells. It clinically manifests as cognitive decline, seizures, and …
View article: Perinatal Enterovirus Infection in Neonates: A Systematic Review
Perinatal Enterovirus Infection in Neonates: A Systematic Review Open
Enteroviruses (EVs) are a common cause of neonatal infections, and perinatal EV infection can lead to severe neonatal disease, including sepsis‐like presentations, and adverse pregnancy outcomes. However, a comprehensive understanding of t…
View article: Physical Activity, Alzheimer Plasma Biomarkers, and Cognition
Physical Activity, Alzheimer Plasma Biomarkers, and Cognition Open
Importance Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. Objective To investigate the associations among …
View article: Friend Turned Foe: <i>Pasteurella multocida</i> Bacteremia Following a Scratch by an Adopted Pekin Duck
Friend Turned Foe: <i>Pasteurella multocida</i> Bacteremia Following a Scratch by an Adopted Pekin Duck Open
Pasteurella multocida is a gram-negative coccobacillus that colonizes the aerodigestive tracts of cats, dogs, birds, and wild animals. This veterinary pathogen spreads to humans via licking, biting, or scratching. Pekin ducks are known car…
View article: Ultrasensitive detection of beta-amyloid 1-42 as a relevant biomarker for Alzheimer's disease in serum
Ultrasensitive detection of beta-amyloid 1-42 as a relevant biomarker for Alzheimer's disease in serum Open
View article: Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers
Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers Open
Importance Blood-based biomarkers for Alzheimer disease (AD) are clinically available, but their value is not well understood in syndromes typically associated with frontotemporal lobar degeneration syndromes (FTLD). Objective To investiga…
View article: A Wearable Stethoscope for Accurate Real-Time Lung Sound Monitoring and Automatic Wheezing Detection Based on an AI Algorithm
A Wearable Stethoscope for Accurate Real-Time Lung Sound Monitoring and Automatic Wheezing Detection Based on an AI Algorithm Open
The various bioacoustics signals obtained with auscultation contain complex clinical information that has been traditionally used as biomarkers, however, they are not extensively used in clinical studies owing to their spatiotemporal limit…
View article: Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association
Executive Summary of 2025 International Conference of the Korean Dementia Association and International Congress of the Asian Society Against Dementia (IC-KDA/ASAD 2025): A Report From the Academic Committee of the Korean Dementia Association Open
The International Conference of the Korean Dementia Association (IC-KDA) 2025 was held jointly with the 19th International Congress of the Asian Society Against Dementia (ASAD) in Seoul, South Korea (May 8-10, 2025), under the theme "Break…
View article: National trends in postoperative complications for lumbar spinal fusion from 2009 to 2022
National trends in postoperative complications for lumbar spinal fusion from 2009 to 2022 Open
Background: Although posterior lumbar fusions (PLFs) have risen in popularity due to minimally invasive techniques and favorable outcomes, complications still arise. Studies show relatively constant rates of postoperative complications fro…
View article: Machine Learning for Dementia Research in People with HIV: A Rapid Review and Future Directions
Machine Learning for Dementia Research in People with HIV: A Rapid Review and Future Directions Open
View article: Predicting PET‐Based Amyloid and Tau Pathology Stages With Plasma Biomarkers in Alzheimer's disease
Predicting PET‐Based Amyloid and Tau Pathology Stages With Plasma Biomarkers in Alzheimer's disease Open
Background We aimed to investigate whether the quantitative analysis of plasma biomarkers could distinguish the pathology stages indicated by positron emission tomography (PET)‐based Thal phase of amyloid and Braak stage of tau. Method A t…
View article: Diagnostic Performance of Plasma Biomarkers for A/T/N Image Classification in Alzheimer's disease
Diagnostic Performance of Plasma Biomarkers for A/T/N Image Classification in Alzheimer's disease Open
Background We aimed to validate the ability of Alzheimer’s disease plasma biomarkers to predict clinical diagnosis and the ability to predict image‐based A/T/N biomarkers positivity in Asian population. We also sought to define the optimal…
View article: Diagnostic Performance of Plasma P‐tau217, NfL, and GFAP for Predicting Alzheimer’s Disease Neuropathology Across Diverse Neurodegenerative Syndromes
Diagnostic Performance of Plasma P‐tau217, NfL, and GFAP for Predicting Alzheimer’s Disease Neuropathology Across Diverse Neurodegenerative Syndromes Open
Background In the era of disease‐modifying treatments for Alzheimer's disease (AD), accurate detection of underlying AD pathology is critical. Blood‐based biomarkers for AD are increasingly available, but their diagnostic performance is no…
View article: Measurement of Blood GFAP Concentration to Evaluate KDS2010 (MAO‐B Inhibitor) Drug in APP/PS1 Mice Using a Magnetic Bead‐based Electrochemical Sensor
Measurement of Blood GFAP Concentration to Evaluate KDS2010 (MAO‐B Inhibitor) Drug in APP/PS1 Mice Using a Magnetic Bead‐based Electrochemical Sensor Open
Background Blood GFAP levels have the potential to reflect and predict worsening disability in individuals with degenerative diseases such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). Recently published research suggests that …
View article: Concordance between amyloid-PET quantification and real-world visual reads: results from IDEAS
Concordance between amyloid-PET quantification and real-world visual reads: results from IDEAS Open
Amyloid-PET detects fibrillar β-amyloid deposits, a defining feature of Alzheimer’s disease. This technology has been used in research for over 20 years, and is now used in clinical practice to guide patient diagnosis and management. Howev…
View article: Efficacy and safety of ephedra-containing oral medications: a systematic review, meta-analysis, and exploratory dose–response analysis for weight reduction
Efficacy and safety of ephedra-containing oral medications: a systematic review, meta-analysis, and exploratory dose–response analysis for weight reduction Open
Introduction Despite the widespread use of ephedra in various forms, including food supplements and herbal prescriptions, comprehensive studies reviewing its efficacy and safety across different countries are lacking. Methods We systematic…
View article: Biomarkers of neurodegeneration across the Global South
Biomarkers of neurodegeneration across the Global South Open
Research on neurodegenerative diseases has predominantly focused on high-income countries in the Global North. This Series paper describes the state of biomarker evidence for neurodegeneration in the Global South, including Latin America, …
View article: Evaluating the Dermatological Benefits of Snowberry (Symphoricarpos albus): A Comparative Analysis of Extracts and Fermented Products from Different Plant Parts
Evaluating the Dermatological Benefits of Snowberry (Symphoricarpos albus): A Comparative Analysis of Extracts and Fermented Products from Different Plant Parts Open
Skin ageing is influenced by both intrinsic and extrinsic factors, with excessive ultraviolet (UV) exposure being a significant contributor. Such exposure can lead to moisture loss, sagging, increased wrinkling, and decreased skin elastici…
View article: Chemo-ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines
Chemo-ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines Open
Expanding the chemical and structural complexity of genetically encoded peptides remains a challenge in peptide therapeutics discovery. Here we report that linear peptides with a reactive β- or γ-keto amide at their N-termini can be synthe…