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View article: <i>ABCB1</i> Gene Polymorphisms and Their Contribution to Cognitive Decline in Mild Cognitive Impairment: A Next-Generation Sequencing Study
<i>ABCB1</i> Gene Polymorphisms and Their Contribution to Cognitive Decline in Mild Cognitive Impairment: A Next-Generation Sequencing Study Open
The ABCB1 gene, encoding the ATP-dependent translocase ABCB1, plays a crucial role in the clearance of amyloid-beta (Aβ) peptides and the transport of cholesterol, implicating it in the pathogenesis of Alzheimer’s disease. The study aims t…
View article: Psychometric Characteristics of the Novel Subjective Cognitive Changes Questionnaire (SCC‐Q) in Older Adults at Risk of Dementia
Psychometric Characteristics of the Novel Subjective Cognitive Changes Questionnaire (SCC‐Q) in Older Adults at Risk of Dementia Open
Background Subjective cognitive complaints (SCC) in the elderly may represent an early cognitive marker of Alzheimer’s disease (AD). Currently, there is no recommended gold standard for evaluating SCC. In addition, available questionnaires…
View article: Six genetically linked mutations in the CD36 gene significantly delay the onset of Alzheimer's disease
Six genetically linked mutations in the CD36 gene significantly delay the onset of Alzheimer's disease Open
The risk of Alzheimer’s disease (AD) has a strong genetic component, also in the case of late-onset AD (LOAD). Attempts to sequence whole genome in large populations of subjects have identified only a few mutations common to most of the pa…
View article: Corrigendum: Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort
Corrigendum: Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort Open
[This corrects the article DOI: 10.3389/fnagi.2021.643271.].
View article: POVINNÉ PLATBY VZTAHUJÍCÍ SE K NEMOVITOSTEM (KROMĚ DANĚ Z NEMOVITÝCH VĚCÍ)
POVINNÉ PLATBY VZTAHUJÍCÍ SE K NEMOVITOSTEM (KROMĚ DANĚ Z NEMOVITÝCH VĚCÍ) Open
Daňové zatížení majetku se spojuje zejména s daní z nemovitých věcí, ale je třeba vidět, že i další platby, které mají povahu poplatků či odvodů se dotýkají nemovitého majetku. Vedle státních poplatků jsou to poplatky místní. S nemovitou v…
View article: Impact of APOE and BDNF Val66Met polymorphisms on spatial navigation and brain morphometry in subjective cognitive decline
Impact of APOE and BDNF Val66Met polymorphisms on spatial navigation and brain morphometry in subjective cognitive decline Open
Background The apolipoprotein E ( APOE ) ɛ4 allele is associated with episodic memory deficits, less accurate spatial navigation and hippocampal atrophy in nondemented older adults. The brain‐derived neurotrophic factor ( BDNF ) Met allele…
View article: Spatial Pattern Separation Testing Differentiates Alzheimer’s Disease Biomarker-Positive and Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment
Spatial Pattern Separation Testing Differentiates Alzheimer’s Disease Biomarker-Positive and Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment Open
Background: The hippocampus, entorhinal cortex (EC), and basal forebrain (BF) are among the earliest regions affected by Alzheimer’s disease (AD) pathology. They play an essential role in spatial pattern separation, a process critical for …
View article: Pathogenesis of Alzheimer’s disease: Involvement of the Choroid Plexus
Pathogenesis of Alzheimer’s disease: Involvement of the Choroid Plexus Open
Summary Aging and Alzheimer’s disease (AD), a major age-related disorder, are both characterized by inflammatory changes in the cerebrospinal fluid (CSF). The origin and the mechanisms underlying these inflammatory changes, however, remain…
View article: Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort
Mild Behavioral Impairment Is Associated With Atrophy of Entorhinal Cortex and Hippocampus in a Memory Clinic Cohort Open
Objectives Mild behavioral impairment (MBI) is a syndrome describing late-onset persistent neuropsychiatric symptoms (NPS) in non-demented older adults. Few studies to date have investigated the associations of MBI with structural brain ch…
View article: Cognitive worry in cognitively normal older adults is associated with decreased memory binding, hippocampal volume and parahippocampal thickness
Cognitive worry in cognitively normal older adults is associated with decreased memory binding, hippocampal volume and parahippocampal thickness Open
Background Worry associated with subjective cognitive decline (cognitive worry) in cognitively normal (CN) older adults has been established as a feature that increases the likelihood of preclinical Alzheimer´s disease (AD). Previously, it…
View article: Moderating Effect of Cognitive Reserve on Brain Integrity and Cognitive Performance
Moderating Effect of Cognitive Reserve on Brain Integrity and Cognitive Performance Open
Dementia is arguably the most devastating condition of older adulthood with treatment options still elusive. Alzheimer’s is the most prevalent form of dementia where cognitive deficits relate strongly to underlying brain pathology. However…
View article: Mild behavioral impairment is associated with atrophy in Alzheimer's disease‐related regions in non‐demented older adults
Mild behavioral impairment is associated with atrophy in Alzheimer's disease‐related regions in non‐demented older adults Open
Background Mild behavioral impairment (MBI) is a recently developed diagnostic concept describing late‐onset persistent neuropsychiatric symptoms (NPS) in older adults without dementia. Few studies to date investigated associations of MBI …
View article: Ratio of serum proBDNF to BDNF and its association with cognitive performance and brain morphometry in mild cognitive impairment
Ratio of serum proBDNF to BDNF and its association with cognitive performance and brain morphometry in mild cognitive impairment Open
Background Brain‐derived neurotrophic factor (BDNF) is the neurotrophin well‐known for its role in neurogenesis, synaptic plasticity and enhancement of long‐term potentiation (LTP). Its precursor proBDNF exhibits opposite biological functi…
View article: Impact of genetic variant of ApoEE4 and BDNF met on BDNF levels, cognition and brain morphometry in mild cognitive impairment
Impact of genetic variant of ApoEE4 and BDNF met on BDNF levels, cognition and brain morphometry in mild cognitive impairment Open
View article: P2‐466: HIPPOCAMPUS MEDIATES THE ASSOCIATION BETWEEN ENTORHINAL CORTEX, BASAL FOREBRAIN AND SEPARATION OF SPATIAL INFORMATION IN EARLY CLINICAL ALZHEIMER'S DISEASE
P2‐466: HIPPOCAMPUS MEDIATES THE ASSOCIATION BETWEEN ENTORHINAL CORTEX, BASAL FOREBRAIN AND SEPARATION OF SPATIAL INFORMATION IN EARLY CLINICAL ALZHEIMER'S DISEASE Open
The hippocampus, entorhinal cortex and basal forebrain (BF) are the first brain structures affected in Alzheimer's disease (AD) and play a key role in spatial memory and navigation. Spatial pattern separation is a process of maintaining no…
View article: P1‐312: DIFFERENT DIAGNOSTIC VALUE OF SELF‐ AND INFORMANT‐REPORTED COGNITIVE COMPLAINTS IN NON‐DEMENTED OLDER ADULTS – DATA FROM THE CZECH BRAIN AGING STUDY
P1‐312: DIFFERENT DIAGNOSTIC VALUE OF SELF‐ AND INFORMANT‐REPORTED COGNITIVE COMPLAINTS IN NON‐DEMENTED OLDER ADULTS – DATA FROM THE CZECH BRAIN AGING STUDY Open
Cognitive complaints (CCs) are either associated with normal ageing, depressive symptoms or may represent an early sign of Alzheimer's disease. The aim was to compare CCs reported by a clinical cohort of non-demented older adults and their…
View article: P1‐310: EXAMINING NEUROPSYCHIATRIC SYMPTOMS IN MILD COGNITIVE IMPAIRMENT, DEMENTIA AND COGNITIVELY HEALTHY OLDER ADULTS USING THE MILD BEHAVIORAL IMPAIRMENT CHECKLIST
P1‐310: EXAMINING NEUROPSYCHIATRIC SYMPTOMS IN MILD COGNITIVE IMPAIRMENT, DEMENTIA AND COGNITIVELY HEALTHY OLDER ADULTS USING THE MILD BEHAVIORAL IMPAIRMENT CHECKLIST Open
Neuropsychiatric symptoms (NPS) are already present in pre-dementia stages. Mild behavioral impairment (MBI) is a newly developed diagnostic concept describing persistent changes in affectivity, motivation, impulse control, social appropri…
View article: P3‐478: SEMANTIC MEMORY BINDING IS ASSOCIATED WITH MEDIAL TEMPORAL LOBE VOLUMES AND CORTICAL THICKNESS IN COGNITIVELY NORMAL OLDER ADULTS: FINDINGS FROM THE CZECH BRAIN AGING STUDY
P3‐478: SEMANTIC MEMORY BINDING IS ASSOCIATED WITH MEDIAL TEMPORAL LOBE VOLUMES AND CORTICAL THICKNESS IN COGNITIVELY NORMAL OLDER ADULTS: FINDINGS FROM THE CZECH BRAIN AGING STUDY Open
In order to identify individuals with preclinical Alzheimer's disease (AD), new challenging memory paradigms evaluating medial temporal dysfunction have been developed. The Memory Binding Test (MBT) is an experimental measure of semantic m…
View article: P2‐346: Different Specific Cognitive Complaints Reflect Lower Cognitive Performance and Depressive Symptomatology in Cognitively Normal Elderly
P2‐346: Different Specific Cognitive Complaints Reflect Lower Cognitive Performance and Depressive Symptomatology in Cognitively Normal Elderly Open
There is emerging evidence that subjective cognitive complaints (SCC) in individuals with normal performance on neuropsychological tests may be an early cognitive marker of incipient Alzheimer's disease, especially in worried subjects who …
View article: White matter lesions and plasma homocystein levels have different influence on cognitive performance among non-demented and demented elderly
White matter lesions and plasma homocystein levels have different influence on cognitive performance among non-demented and demented elderly Open