Hana Shafique
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View article: KRM-II-81, a β3-Preferring GABAA Receptor Potentiator, Blocks Handling-Induced Seizures in Theiler’s Murine Encephalomyelitis Virus-Infected Mice
KRM-II-81, a β3-Preferring GABAA Receptor Potentiator, Blocks Handling-Induced Seizures in Theiler’s Murine Encephalomyelitis Virus-Infected Mice Open
Background: The GABAA receptor (GABAAR) potentiator, KRM-II-81, is being developed as a novel antiseizure medication with reduced potential for sedation, tolerance development, and abuse liability. Although KRM-II-81 has been shown to prov…
View article: Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures
Defining hypoxia in cancer: A landmark evaluation of hypoxia gene expression signatures Open
Tumor hypoxia drives metabolic shifts, cancer progression, and therapeutic resistance. Challenges in quantifying hypoxia have hindered the exploitation of this potential "Achilles' heel." While gene expression signatures have shown promise…
View article: Vascular adhesion molecule 1+ fibro-adipogenic progenitors mark fatty infiltration in chronic limb-threatening ischemia
Vascular adhesion molecule 1+ fibro-adipogenic progenitors mark fatty infiltration in chronic limb-threatening ischemia Open
Myosteatosis, the pathological accumulation of fat within skeletal muscle, is increasingly recognized as a critical determinant of adverse clinical outcomes in peripheral arterial disease (PAD). Current therapies for PAD focus on revascula…
View article: Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management
Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management Open
Traumatic brain injury (TBI) has reached epidemic proportions worldwide. The consequences of TBI can be severe even with repetitive mild trauma. If death and coma are avoided, the consequences of TBI in the long term typically involve dizz…
View article: (R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders
(R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders Open
NMDA receptor antagonists have potential for therapeutics in neurological and psychiatric diseases, including neurodegenerative diseases, epilepsy, traumatic brain injury, substance abuse disorder (SUD), and major depressive disorder (MDD)…
View article: Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK
Diversity of thought: public perceptions of genetic testing across ethnic groups in the UK Open
Genetic testing is becoming rapidly more accessible to the general populous either through or outside healthcare systems. Few large-scale studies have been carried out to gauge public opinion in this growing area. Here, we undertook the la…
View article: Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus
Effects of Tetrahydrocannabinol and Cannabidiol on Brain-Derived Neurotrophic Factor and Tropomyosin Receptor Kinase B Expression in the Adolescent Hippocampus Open
Introduction: Adolescence is an important phase in brain maturation, specifically it is a time during which weak synapses are pruned and neural pathways are strengthened. Adolescence is also a time of experimentation with drugs, including …