Hanane Chamma
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View article: The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling Open
The detection of cytosolic dsDNA is tightly regulated to avoid pathological inflammatory responses. A major pathway involved in their detection relies on the cyclic GMP-AMP synthase (cGAS) that triggers activation of the Stimulator of inte…
View article: The crosstalk between DNA-PK and cGAS drives tumor immunogenicity
The crosstalk between DNA-PK and cGAS drives tumor immunogenicity Open
SUMMARY Cytosolic DNAs promote inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP) synthase (cGAS). It has been thus suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used gl…
View article: Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes Open
The maintenance of genomic stability in multicellular organisms relies on the DNA damage response (DDR). The DDR encompasses several interconnected pathways that cooperate to ensure the repair of genomic lesions. Besides their repair funct…
View article: Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses Open
Summary Inflammatory disorders are major health issues in which immune function and metabolic homeostasis are concertedly altered. Yet, the molecular mechanisms coordinating innate and metabolic pathways in homeostatic conditions are poorl…