Hanchen Huang
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View article: An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery
An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery Open
High-throughput technologies now produce a wide array of omics data, from genomic and transcriptomic profiles to epigenomic and proteomic measurements. Integrating multiple omics layers measured on the same samples can reveal cross-layer m…
View article: Discomfort sources and solutions for non-pet-owner customers in pet-friendly restaurants
Discomfort sources and solutions for non-pet-owner customers in pet-friendly restaurants Open
With the rising rate of pet ownership, pet-friendly restaurants have become a growing market trend. However, non-pet-owner customers often feel discomfort in these spaces, negatively impacting their dining experience and willingness to pat…
View article: An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery
An Integrative Multi-Omics Random Forest Framework for Robust Biomarker Discovery Open
High-throughput technologies now produce a wide array of omics data, from genomic and transcriptomic profiles to epigenomic and proteomic measurements. Integrating these diverse data types can yield deeper insights into the biological mech…
View article: Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer
Integrating Tumor and Organoid DNA Methylation Profiles Reveals Robust Predictors of Chemotherapy Response in Rectal Cancer Open
Rectal cancer patients display heterogeneous responses to neoadjuvant treatment—including the intensive total neoadjuvant therapy (TNT)—and reliable biomarkers are lacking to guide which tumors will benefit most from these regimens. Here, …
View article: MIAMI‐AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease
MIAMI‐AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development of AD. Given…
View article: Utilizing Analytic Network Process for Evaluating Event Management Companies: A Case Study in Celebration Activities
Utilizing Analytic Network Process for Evaluating Event Management Companies: A Case Study in Celebration Activities Open
This study explores the selection model for event contracting companies, analyzing the differences in selection criteria across various types of activities (such as arts and culture, industry and community development, and innovative festi…
View article: Exploring the Selection and Training of Tour Leaders: An Evaluation Model Based on the Analytic Hierarchy Process
Exploring the Selection and Training of Tour Leaders: An Evaluation Model Based on the Analytic Hierarchy Process Open
Since the outbreak of the global pandemic in 2020, the tourism industry in various countries has nearly come to a standstill, resulting in many individuals who previously worked as tour leaders shifting to other professions due to financia…
View article: Analysis of Key Factors Influencing Penghu Tourism Development using the Delphi Method and AHP
Analysis of Key Factors Influencing Penghu Tourism Development using the Delphi Method and AHP Open
As Taiwan's largest offshore island, Penghu boasts a rich historical and cultural heritage, with a development history that predates Taiwan by 400 years. The island’s unique climate, geographical environment, and natural resources have sha…
View article: A Neural Network Approach to Understanding Employee Retention Dynamics: Insights from Feature Importance Analysis
A Neural Network Approach to Understanding Employee Retention Dynamics: Insights from Feature Importance Analysis Open
In today’s business environment, employee retention has become a significant challenge, as employee turnover can lead to decreased productivity, increased costs, and reduced morale. This study aims to leverage neural network technology to …
View article: Enhancing Organizational Efficiency of the Lantern Festival in Penghu, Taiwan Through Information Technology: Key Factors Analysis
Enhancing Organizational Efficiency of the Lantern Festival in Penghu, Taiwan Through Information Technology: Key Factors Analysis Open
The Lantern Festival in Penghu, Taiwan, has become one of the region's most important cultural events, attracting numerous tourists and garnering extensive media coverage. This festival combines local traditions and religious beliefs, serv…
View article: Analysis of Tourist Experiences at Dark Tourism Sites in Kinmen: Clustering Analysis of Motivations, Emotional Responses, and Satisfaction
Analysis of Tourist Experiences at Dark Tourism Sites in Kinmen: Clustering Analysis of Motivations, Emotional Responses, and Satisfaction Open
Dark tourism involves visiting sites associated with death, disaster, and major historical tragedies. Kinmen, Taiwan, known for its history of multiple wars, features notable dark tourism sites such as Mount Taiwu, the Guningtou War Museum…
View article: Analyzing selection criteria weight of exhibition contractors using analytic network process
Analyzing selection criteria weight of exhibition contractors using analytic network process Open
Selecting exhibition contractors based solely on the lowest price often results in low-quality services and products due to unreasonably low bids. To address this issue, the Most Advantageous Bid (MAB) method is proposed, emphasizing compr…
View article: Research on key factors of travel agency website service quality
Research on key factors of travel agency website service quality Open
In the internet environment of e-commerce, website operators need to focus on meeting customer needs and increasing consumption opportunities. A company's success on an online platform depends not only on the quality of its products or ser…
View article: Discovery of Oncogenic Mediator Genes in Rectal Cancer Chemotherapy Response using Gene Expression Data from Matched Tumor and Patient-Derived Organoid
Discovery of Oncogenic Mediator Genes in Rectal Cancer Chemotherapy Response using Gene Expression Data from Matched Tumor and Patient-Derived Organoid Open
Rectal cancer (RC) presents significant treatment challenges, particularly in the context of chemotherapy resistance. Addressing this, our study pioneers the use of matched RC tumor tissue and patient-derived organoid (PDO) models coupled …
View article: Enhancing Chemotherapy Response Prediction via Matched Colorectal Tumor-Organoid Gene Expression Analysis and Network-Based Biomarker Selection
Enhancing Chemotherapy Response Prediction via Matched Colorectal Tumor-Organoid Gene Expression Analysis and Network-Based Biomarker Selection Open
Colorectal cancer (CRC) poses significant challenges in chemotherapy response prediction due to its molecular heterogeneity. This study introduces an innovative methodology that leverages gene expression data generated from matched colorec…
View article: MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease
MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease Open
Alzheimer’s disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development of AD. Given that AD af…
View article: MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease
MIAMI-AD (Methylation in Aging and Methylation in AD): an integrative knowledgebase that facilitates explorations of DNA methylation across sex, aging, and Alzheimer’s disease Open
Alzheimer’s disease (AD) is a common neurodegenerative disorder with a significant impact on aging populations. DNA methylation (DNAm) alterations have been implicated in both the aging processes and the development of AD. Given that AD af…
View article: Research on Decision Making Regarding in Dating Events for Unmarried Female Junior High School Teachers
Research on Decision Making Regarding in Dating Events for Unmarried Female Junior High School Teachers Open
This study intends to investigate the mate selection criteria and weights of unmarried female junior high school teachers in Taiwan. This study used the Delphi method to clarify mate selection criteria. The primary assessment criteria incl…
View article: Low-temperature bonding with spaced nanorods and eutectic alloys
Low-temperature bonding with spaced nanorods and eutectic alloys Open
Bonded surfaces are formed by adhering first nanorods and second nanorods to respective first and second surfaces. The first shell is formed on the first nanorods and the second shell is formed on the second nanorods, wherein at least one …
View article: Design of high SERS sensitive substrates based on branched Ti nanorods
Design of high SERS sensitive substrates based on branched Ti nanorods Open
This paper reports a rational design of branched titanium (Ti) nanorods formed by glancing angle physical vapor deposition and their applications as substrates for surface-enhanced Raman scattering (SERS). Ti nanorods with branches have la…
View article: Design of Branched Ti Nanorods for High SERS Sensitivity
Design of Branched Ti Nanorods for High SERS Sensitivity Open
This paper reports a rational design of branched titanium (Ti) nanorods formed by glancing angle physical vapor deposition and their applications as substrates for surface-enhanced Raman scattering (SERS). Ti nanorods with branches have la…
View article: Tourism Demand Forecasting Model Using Neural Network
Tourism Demand Forecasting Model Using Neural Network Open
Travel agencies should be able to judge the market demand for tourism to develop sales plans accordingly. However, many travel agencies lack the ability to judge the market demand for tourism, and thus make risky business decisions. Based …
View article: Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes
Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes Open
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (BL1, BL2), a mesenchymal (M) a…
View article: Branching of Titanium Nanorods
Branching of Titanium Nanorods Open
One dimensional titanium nanorod structures formed by glancing angle physical vapor deposition have branches while other hexagonal closed packed metals do not. Based on physical vapor deposition and characterizations using electron microsc…