Explanipedia

Impact of patulin on apoptosis, autophagy, and tumor growth in human malignant mesothelioma and normal mesothelial cells Open

Hande Yüce, Yasemin Şahin · 2025

Eczacılıkta Güncel Araştırmalar V Open

Songül Ünüvar, Hande Yüce, Mehtap Tuğrak Sakarya, Seda Aladağ Kurt, Mefküre Durmuş , et al. · 2025

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Sonographic Measurement of Adipose Tissue; Potential Biomarkers of Brown Fat Open

Zeynep Zeren Uçar, Osman Sümengen, Hande Yüce, Feray AYDIN · 2025

Objective: The aim of this study was to investigate the feasibility of non-contrast ultrasonography in imaging brown adipose tissue, which plays a role in adipogenesis, thermogenesis, angiogenesis, immune cell interactions, and neurite out…

Effect of beta-glucan on oxidative stress, inflammation, hormonal and histopathological changes in dehydroepiandrosterone-induced polycystic ovary syndrome Open

Hande Yüce, Neşe Başak Türkmen, Muhterem Aydın, Aslı Çetin, Dilan AŞKIN ÖZEK , et al. · 2024

A class of dietary fibers and biologically active polysaccharides from natural sources, beta-glucans (βTGs) have bioactive capabilities. The anti-tumor, anti-inflammatory, prebiotic, anti-obesity, anti-allergic, anti-microbial, antiviral, …

PREDICTIVE BIOMARKERS OF LIVING DONOR LIVER TRANSPLANTATION Open

Ömer Faruk ÇİFTÇİ, Tevfik Tolga Şahin, Hande Yüce, Sezai Yılmaz, Neşe Başak Türkmen , et al. · 2023

Objective: Liver transplantation using a living donor (LDLT) is currently the most popular method used in the worldwide. Appropriate biomarkers that predict graft status should be used to detect early post-transplant complications that may…

Eczacılıkta Güncel Araştırmalar Open

Elif Erdönmez, Hafize Yuca, Benan Kalaycı, Saime Gökgöz, Leyla Paşayeva , et al. · 2023

Dermokozmetik Ürünlerde Bulunan Doğal Kaynaklı Hammaddeler Elif ERDÖNMEZ Hafize YUCA Dermatolojide Tıbbi Bitkilerin Önemi Benan KALAYCI Helichrysum Plicatum Ssp. Plicatum Bitkisinin Farmakolojik Açıdan Değerlendirilmesi Saime GÖKGÖZ Leyla …

Current Pandemic in the World: Monkeypox from Past to Present Open

Yasemin Şahin, Hande Yüce, Songül Ünüvar, Osman Çiftçi · 2023

Monkeypox is a zoonotic viral infection that was first identified in humans in 1970 in the Democratic Republic of Congo. The cases seen again in early May 2022 have reached 78.000 as of today. On July 23, 2022, the World Health Organizatio…

18β-glycyrrhetinic acid attenuates global cerebral ischemia/reperfusion-induced cardiac damage in C57BL/J6 mice Open

Neşe Başak Türkmen, Hande Yüce, Aslı Çetin, Yasemin Şahin, İdris Ayhan , et al. · 2023

The aim of the present study is to investigate the cardioprotective effects of 18β-glycyrrhetinic acid (18β -GA) against oxidative and histological damage caused by global cerebral ischemia/ reperfusion (I/R) in C57BL/J6 mice. All male mic…

Pharmacokinetic Interaction of Favipiravir with Citalopram and Pioglitazone Open

ZELİHA KESKİN ALKAÇ, Dilan AŞKIN ÖZEK, Hande Yüce, Fatih Ahmet Korkak, Sümeyye Aslan , et al. · 2022

The current study's objective was to investigate the interactions of favipiravir with pioglitazone and citalopram. 25 Spraque-Dawley female rats were used in the study. Rats in groups 1 and 4 were given pioglitazone (1 mg/kg/day) for 7 day…

Evaluation of serum neopterin, periostin, Tenascin‐C, tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-2 levels in obese pregnant women Open

Rauf Melekoğlu, Songül Ünüvar, Neşe Başak Türkmen, Aslı Çetin, Nesibe Zeyveli Çelik , et al. · 2022

This study demonstrated that class II-III obese pregnant women had significantly higher serum levels of neopterin, periostin, Tenascin-C, and tissue inhibitor of metalloproteinase-1 in the third trimester. These higher serum levels may be …

Drug-Drug Interaction of Aldehyde Oxidase Inhibitor and Xanthine Oxidase Inhibitor with Favipiravir Open

Dilan AŞKIN ÖZEK, Zeliha Keskin Alkaç, Hande Yüce, Neşe Başak Türkmen, Sümeyye Aslan , et al. · 2022

Aim: Favipiravir is an effective antiviral used in the treatment of COVID-19. It is metabolized by aldehyde oxidase (AO) and xanthine oxidase (XO). This study investigated drug-drug interactions between favipiravir with both AO substrate a…

Molecular docking and in vitro anticancer studies of silver(I)-N-heterocyclic carbene complexes Open

Mitat Akkoç, Siraj Khan, Hande Yüce, Neşe Başak Türkmen, Şeyma Yaşar , et al. · 2022

A series of symmetric and unsymmetrical benzimidazolium-based N-heterocyclic carbene (NHC) precursors (1a-i) and their silver complexes (2a-i) have been synthesized. The Ag(I)-NHC complexes were characterized by ¹H…

PATULİNİN KARACİĞER VE AKCİĞER KANSERİ HÜCRE HATLARI ÜZERİNDEKİ İN VİTRO ANTİTÜMÖR AKTİVİTESİ Open

Hande Yüce, Neşe Başak Türkmen, Selinay Şenkal, Dilan AŞKIN ÖZEK, Ezgi Bulut Okumuş , et al. · 2022

Objective: Patulin is a mycotoxin produced by some molds, mainly Aspergillus and Penicillium, and is responsible for mycotoxicosis in animals and humans. Although there are still no detailed data on the antitumor activity of patulin, some …

Molecular Docking and in Vitro Anticancer Studies of Silver(I)-N-Heterocyclic Carbene Complexes Open

Mitat Akkoç, Siraj Ahmed Khan, Hande Yüce, Neşe Başak Türkmen, Şeyma Yaşar , et al. · 2022

Risk of Ecotoxicity Due to Bioaccumulation of Antidepressants: Systematic Review Open

Hande Yüce, Songül Ünüvar · 2022

İlaçlar, önemli çevresel kirleticiler arasında yer almaktadırlar. Antidepresan ilaçlar, hem yer altı hem de yer üstü sularında sıklıkla rastlanan kontaminantlardır. Antidepresan ilaçların su canlılarında tespit edilmesinin 2 nedeni vardır.…

Molecular Diagnostic Tests and Pharmacological Therapy Approaches in Celiac Disease: A Systematic Review Open

Münevver Nazlıcan ZENGİN, Yasemin Şahin, Hande Yüce, Osman Çiftçi · 2022

Otoimmün hastalıklar otoantikor üretimi ve doku yıkımı ile karakterize olup kalıtsal ve çevresel faktörlerden etkilenmektedir. Çölyak hastalığı genetik olarak yatkın olan bireylerde diyetle alınan glutene karşı duyarlılık sonucunda ortaya …

Molecular Docking and in Vitro Anticancer Studies of Silver(I)-N-Heterocyclic Carbene Complexes Open

Mitat Akkoç, Siraj Khan, Hande Yüce, Neşe Başak Türkmen, Şeyma Yaşar , et al. · 2022

Use of Amatoxin Conjugates in Antibody Drug Conjugates, One of the Current Treatment Approaches: Systematic Review Open

Hande Yüce, Songül Ünüvar · 2022

Geleneksel kanser kemoterapisinde kullanılan ajanlar düşük terapötik indekse sahiptirler. Bu nedenle monoklonal bir antikor, bağlayıcı bir molekül ve sitotoksik bir ajandan oluşan immünokonjugatlar olan antikor-ilaç konjugatları (AİK) geli…

Alternative Model in Parkinson's Disease: Dictyostelium discoideum: Systematic Review Open

Yasemin Şahin, Hande Yüce · 2022

Nörodejeneratif hastalıkların tedavisinde, nöronal patogeneze neden olan olayların anlaşılması ve uygun tedavilerin geliştirilmesi temel basamaktır. Nörodejeneratif hastalıkların çoğu mitokondriyal disfonksiyon ile ilişkilidir. İnsanlarda …

Evaluation of In Vitro and In Vivo Anticancer Activities of Mycotoxins Open

Hande Yüce, Songül Ünüvar · 2022

Mikotoksinler, hasat öncesi, hasat sırasında ve/veya hasat sonrası tarımsal ürünleri kontamine eden ve çoğunlukla hayvan ve insanlarda toksisiteye neden olan, mantarlar tarafından salınan ikincil metabolitlerdir. Bu derlemenin amacı, manta…

TAURİN, KAPSAİSİN, MELATONİN VE BETA KAROTENİN MEME KANSERİ HÜCRE HATLARI ÜZERİNDEKİ ANTİPROLİFERATİF, ANTİMİGRASYON VE ANTİOKSİDAN ETKİLERİNİN ARAŞTIRILMASI Open

Hande Yüce, Neşe Başak Türkmen, Dilan AŞKIN ÖZEK, Songül Ünüvar · 2021

Objective: The aim of this study was to evaluate the antiproliferative, antimigration and antioxidant activities of antioxidant substances such as taurine, capsaicin, melatonin and beta carotene on human breast cancer cells. Material and M…

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma Open

Zübeyde Tanrıverdi, Fatih Meteroğlu, Hande Yüce, Abdurrahman Şenyiğit, Mümtaz Işcan , et al. · 2021

Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indola…

The Ameliorate Effects of Nerolidol on Thioasteamide-induced Oxidative Damage in Heart and Kidney Tissue Open

Neşe Başak Türkmen, Hande Yüce, Aslı Çetin, Yasemin Şahin, Osman Çiftçi · 2021

OBJECTIVES: Thioacetamide (TAA) is an organosulfur, white crystalline compound having liver injury. However, it shows toxic effects on many organs. The reverts the oxidative stress created by TAA on the heart and kidney, and decreased lipi…

Evaluation of the Diagnostic Significance of Some Biomarkers in Pruritic Dermatological Diseases: A Case-Control Study Open

Neşe Başak Türkmen, Dursun Türkmen, Hande Yüce, Mücahit Marsak, Zübeyde Tanrıverdi , et al. · 2021

Objective: Indolamine-2,3-dioxygenase (IDO), neopterin, periostin, tenascin-C (TN-C), chitinase-3-like protein 1 (CHI3L1/YKL- 40) YKL-40 have been previously described as diagnostic markers for a number of pathologies. The aim of our study…

The Assessment of Multiple Organ Involvement Due to SARS-CoV-2: Traditional Review Open

Hande Yüce, Songül Ünüvar · 2021

Şiddetli akut solunum yolu sendromu-koronavirüs-2 [severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)] enfeksiyonu damlacık yoluyla bulaşan bir solunum yolu hastalığı olarak ortaya çıkmasına rağmen, enfekte olan hastalarda solunu…

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