Hangping Yao
YOU?
Author Swipe
View article: Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines
Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines Open
Understanding and enhancing vaccine‐induced immune responses in the elderly population is critical, as they face elevated risks of severe COVID‐19. This work systematically delineates age‐associated alterations in innate and adaptive immun…
View article: CircRNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against MPXV
CircRNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against MPXV Open
The mpox outbreak has been declared a Public Health Emergency of International Concern on two occasions, with the status remaining effective, highlighting the urgency of this global health crisis. Developing safe and effective vaccines spe…
View article: MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence
MSP-RON signaling in liver pathobiology and as an emerging therapeutic target: a review of the current evidence Open
The liver is a crucial organ in the human body and is responsible for various functions, including digestion, detoxification, metabolism, and immune response. Proper hepatic function is vital for maintaining systemic homeostasis, and dysre…
View article: Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV
Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV Open
Non-cholesterol sterol metabolism plays a crucial role in immune regulation. However, the non-cholesterol sterol profiles, its association with gut dysbiosis, and its impact on the CD4 + T cell recovery in people living with HIV (PLWH) are…
View article: Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus
Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus Open
The H5 subtype avian influenza viruses (AIVs) pose a major threat to wild fowl and poultry. Additionally, they can overcome the species barrier, inducing human infection, which may become fatal. Thus, the H5 subtype AIVs remain a global pu…
View article: Evaluating Bacillus Calmette–Guérin Polysaccharide Nucleic Acid as an Adjuvant for Influenza Vaccines in Mice
Evaluating Bacillus Calmette–Guérin Polysaccharide Nucleic Acid as an Adjuvant for Influenza Vaccines in Mice Open
Background To enhance influenza vaccine efficacy, it is essential to investigate new adjuvants that are both safe and effective. In a recent study utilizing a mouse model, Bacillus Calmette–Guérin polysaccharide nucleic acid (BCG‐PSN) emer…
View article: A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes
A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes Open
Unlike the human-infecting H10N3 and H10N8 AIVs acquiring six internal protein-coding genes from H9N2 AIVs in domestic poultry, the human-infecting H10N5 AIV was generated through multiple reassortments among viruses mainly carried by wild…
View article: Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity Open
The bivalent nature of IgG enhances its neutralization potency against enveloped viruses; however, on-virion structural details of IgG bivalent binding with antigens remain elusive. Here we used cryo-ET to investigate how two potent IgGs P…
View article: Rapid and Sensitive Quantum Dots Immunochromatographic Strip for H10 Subtype Avian Influenza Virus Detection
Rapid and Sensitive Quantum Dots Immunochromatographic Strip for H10 Subtype Avian Influenza Virus Detection Open
The H10 subtype avian influenza virus (AIV), an important zoonotic pathogen, is widely prevalent in host species (wild fowl) and continues to infect humans, imposing a huge threat to public health. Thus, the H10 subtype AIV is considered a…
View article: China’s Malaria R&D Innovations: A Scoping Review from 2013–2023
China’s Malaria R&D Innovations: A Scoping Review from 2013–2023 Open
Malaria remains a major global health challenge. Understanding the research progress of the potential innovative tools is important for malaria elimination. This scoping review aims to explore China's research and development (R&D;) advanc…
View article: Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV
Short-chain fatty acids play a key role in antibody response to SARS-CoV-2 infection in people living with HIV Open
High SARS-CoV-2-specific antibody levels can protect against SARS-CoV-2 reinfection. The gut microbiome can affect a host's immune response. However, its role in the antibody response to SARS-CoV-2 in people living with HIV (PLWH) remains …
View article: DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides
DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides Open
Antimicrobial peptides (AMPs) are potential candidates for treating multidrug-resistant bacterial infections, yet only a small number of them have progressed into clinical trials. The main challenges include the poor stability and hemolyti…
View article: Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV
Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV Open
Both HIV infection and antiretroviral therapy (ART) affect the oral microbiome. Whether successful treatment with ART in people living with HIV (PLWH), which leads to a significant decline in viral loads and immune reconstitution, is assoc…
View article: Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2
Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2 Open
RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion …
View article: Sulfated liposome-based artificial cell membrane glycocalyx nanodecoys for coronavirus inactivation by membrane fusion
Sulfated liposome-based artificial cell membrane glycocalyx nanodecoys for coronavirus inactivation by membrane fusion Open
As a broad-spectrum antiviral nanoparticle, the cell membrane nanodecoy is a promising strategy for preventing viral infections. However, most of the cell membrane nanodecoys can only catch virus and cannot induce inactivation, which may b…
View article: HSC70，HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Chaperone-Mediated Autophagy
HSC70，HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Chaperone-Mediated Autophagy Open
Background Ebola virus (EBOV) can induce autophagy to benefit the virus life cycle, but detailed mechanisms remain to be elucidated. We previously found that EBOV GP and VP40 proteins interact with host chaperones, including HSC70 (HSPA8),…
View article: In situ architecture and membrane fusion of SARS-CoV-2 Delta variant
In situ architecture and membrane fusion of SARS-CoV-2 Delta variant Open
Among the current five Variants of Concern, infections caused by SARS-CoV-2 B.1.617.2 (Delta) variant are often associated with the greatest severity. Despite recent advances on the molecular basis of elevated pathogenicity using recombina…
View article: Immune interference in effectiveness of influenza and COVID-19 vaccination
Immune interference in effectiveness of influenza and COVID-19 vaccination Open
Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and po…
View article: Supplementary Figure 5 from RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE
Supplementary Figure 5 from RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE Open
Fig. S5 is about the effect of Zt/g4-MMAE on tumor weight and number.
View article: Supplementary Figure 3 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Supplementary Figure 3 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents Open
PDF file - 59K, Figure S3: Effect of PHA665752, Compound-I, and BMS-777607 on induction of polyploidy in breast cancer cells.
View article: Supplementary Table 2 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Supplementary Table 2 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents Open
PDF file - 57K, Supplementary Table 2 Increased resistance of BMS-777607-induced breast cancer polyploid cells in response to cytotoxic chemotherapy agents.