Hangbin Jin
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View article: Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors
Demystifying metabolic‒immune crosstalk: how amino acid metabolic reprogramming shapes the malignant phenotype and macrophage polarization of biliary and pancreatic tumors Open
Biliary and pancreatic malignant tumors refer to biliary tract carcinoma (BTC) and pancreatic cancer (PC), among which BTC mainly includes cholangiocarcinoma (CCA) and gallbladder cancer (GBC), and their prognosis is poor because of the la…
View article: A comparative study of extracorporeal shock wave lithotripsy and cholangioscopy-guided lithotripsy in the management of complex biliary stones: A randomized trial
A comparative study of extracorporeal shock wave lithotripsy and cholangioscopy-guided lithotripsy in the management of complex biliary stones: A randomized trial Open
BACKGROUND Large and impacted common bile duct stones (CBDSs) cannot be removed by conventional endoscopic retrograde cholangiopancreatography (ERCP), and extracorporeal shock wave lithotripsy (ESWL) or cholangioscopy-guided lithotripsy is…
View article: Complex interplay between type 2 diabetes mellitus and pancreatic cancer: insights from observational and mendelian randomization analyses
Complex interplay between type 2 diabetes mellitus and pancreatic cancer: insights from observational and mendelian randomization analyses Open
not applicable.
View article: Carbapenem-resistant Enterobacterales sepsis following endoscopic retrograde cholangiopancreatography: risk factors for 30-day all-cause mortality and the development of a nomogram based on a retrospective cohort
Carbapenem-resistant Enterobacterales sepsis following endoscopic retrograde cholangiopancreatography: risk factors for 30-day all-cause mortality and the development of a nomogram based on a retrospective cohort Open
Background Endoscopic retrograde cholangiopancreatography (ERCP) has become a routine endoscopic procedure that is essential for diagnosing and managing various conditions, including gallstone extraction and the treatment of bile duct and …
View article: Cholangioscopy-guided laser ablation for intraductal papillary neoplasm of bile duct
Cholangioscopy-guided laser ablation for intraductal papillary neoplasm of bile duct Open
A 65-year-old man with a history of metastatic bladder cancer was admitted with jaundice. Blood tests revealed a cholestatic pattern of liver function, hyperbilirubinemia, and deranged clotting profile. Computed tomography and magnetic res…
View article: Balloon catheter‐assisted endoscopic resection for papillary adenoma of non‐exposed protruded type (with video)
Balloon catheter‐assisted endoscopic resection for papillary adenoma of non‐exposed protruded type (with video) Open
Papillary adenomas, known precursors to papillary adenocarcinoma, warrant close monitoring due to their malignant potential. Historically, surgical resection represented the mainstay of treatment for papillary adenomas with intraductal ext…
View article: Comprehensive analysis of the expression, prognostic, and immune infiltration for COL4s in stomach adenocarcinoma
Comprehensive analysis of the expression, prognostic, and immune infiltration for COL4s in stomach adenocarcinoma Open
Background Collagen (COL) genes, play a key role in tumor invasion and metastasis, are involved in tumor extracellular matrix (ECM)-receptor interactions and focal adhesion pathways. However, studies focusing on the diagnostic value of the…
View article: Global research trends and hotspots between pancreatic cancer and diabetes from2004 to 2024: A bibliometric analysis
Global research trends and hotspots between pancreatic cancer and diabetes from2004 to 2024: A bibliometric analysis Open
Background Pancreatic cancer is one of the malignant tumors of digestive tract. In recent years, more and more studies have shown that there is a close and complex relationship between diabetes and pancreatic cancer. However, there is no b…
View article: Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK
Hyperthermia improves gemcitabine sensitivity of pancreatic cancer cells by suppressing the EFNA4/β-catenin axis and activating dCK Open
This study delineates the role of hyperthermia in enhancing GEM sensitivity of PC cells, primarily mediated through the suppression of the EFNA4/β-catenin axis and activation of dCK.
View article: LC3-dependent extracellular vesicles promote M-MDSC accumulation and immunosuppression in colorectal cancer
LC3-dependent extracellular vesicles promote M-MDSC accumulation and immunosuppression in colorectal cancer Open
For a long time, myeloid-derived suppressor cells (MDSCs) dilated in circulation system of colorectal cancer (CRC) patients have been puzzling clinicians. Various evidence shows that MDSCs constitute the bulk of immunosuppression in CRC, w…
View article: Assessment of safety and adverse events in endoscopic radiofrequency ablation for malignant biliary obstruction
Assessment of safety and adverse events in endoscopic radiofrequency ablation for malignant biliary obstruction Open
Background: Endoscopic radiofrequency ablation (RFA) is used for the treatment of unresectable malignant biliary obstruction (MBO). The postoperative adverse events associated with RFA treatment have gained importance. Objective: To invest…
View article: HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma Open
Objective The dysregulation of the human high-temperature requirement A (HtrA) family of serine proteases is associated with many malignancies. However, there are few reports on HtrAs in head and neck squamous cell carcinoma (HNSCC). The a…
View article: Development and Assessment of a Novel Predictive Nomogram to Predict the Risk of Secondary CR-GNB Bloodstream Infections among CR-GNB Carriers in the Gastroenterology Department: A Retrospective Case–Control Study
Development and Assessment of a Novel Predictive Nomogram to Predict the Risk of Secondary CR-GNB Bloodstream Infections among CR-GNB Carriers in the Gastroenterology Department: A Retrospective Case–Control Study Open
Background: With the number of critically ill patients increasing in gastroenterology departments (GEDs), infections associated with Carbapenem-resistant Gram-negative bacteria (CR-GNB) are of great concern in GED. However, no CR-GNB blood…
View article: Risk Factors for Carbapenem Resistant Gram Negative Bacteria (CR-GNB) Carriage Upon Admission to the Gastroenterology Department in a Tertiary First Class Hospital of China: Development and Assessment of a New Predictive Nomogram
Risk Factors for Carbapenem Resistant Gram Negative Bacteria (CR-GNB) Carriage Upon Admission to the Gastroenterology Department in a Tertiary First Class Hospital of China: Development and Assessment of a New Predictive Nomogram Open
With an estimate of individual risk using the nomogram developed in this study, clinicians and nurses can take more timely infection preventive measures on isolation, cohorting and medical interventions.
View article: Early Versus Delayed Enteral Feeding in Predicted Severe Acute Gallstone Pancreatitis: A Retrospective Study
Early Versus Delayed Enteral Feeding in Predicted Severe Acute Gallstone Pancreatitis: A Retrospective Study Open
Background The optimal timing of enteral nutrition (EN) initiation in predicted severe acute gallstone pancreatitis (SAGP) and its influence on disease outcomes are not well known. Methods We conducted a retrospective study of patients wit…
View article: Early versus delayed cholecystectomy for mild gallstone pancreatitis
Early versus delayed cholecystectomy for mild gallstone pancreatitis Open
Review question / Objective: Acute pancreatitis is one of the most common gastrointestinal disorders requiring e m e rg e n c y a d m i s s i o n t o h o s p i t a l .Gallstones remain the most common cause for acute pancreatitis.After res…
View article: The Diagnostic Value of Serum Gastrin-17 and Pepsinogen for Gastric Cancer Screening in Eastern China
The Diagnostic Value of Serum Gastrin-17 and Pepsinogen for Gastric Cancer Screening in Eastern China Open
Objective. To evaluate the diagnostic value of gastrin-17 (G-17) and pepsinogen (PG) in gastric cancer (GC) screening in China, especially eastern China, and to determine the best diagnostic combination and threshold (cutoff values) to scr…
View article: Biliary Microbial Structure of Gallstone Patients With a History of Endoscopic Sphincterotomy Surgery
Biliary Microbial Structure of Gallstone Patients With a History of Endoscopic Sphincterotomy Surgery Open
The biliary microbiota is related to the pathogenesis of human bile duct stones. However, the extent to which a history of invasive endoscopic sphincterotomy (EST) affects the biliary bacterial community remains largely unknown. We collect…
View article: Endoscopic management of pancreaticopleural fistula in a pediatric patient
Endoscopic management of pancreaticopleural fistula in a pediatric patient Open
Introduction: Pancreaticopleural fistula (PPF) is a rare but serious complication of pancreatic disorders. As the clinical presentations of PPF are often deceptive, it can cause a delay in the timely diagnosis and proper treatment. PPF is …
View article: Endoscopic ultrasound‐guided versus endoscopic retrograde cholangiopancreatography‐guided biliary drainage for primary treatment of distal malignant biliary obstruction: A systematic review and meta‐analysis
Endoscopic ultrasound‐guided versus endoscopic retrograde cholangiopancreatography‐guided biliary drainage for primary treatment of distal malignant biliary obstruction: A systematic review and meta‐analysis Open
Objectives Current evidence supporting the utility of endoscopic ultrasound‐guided biliary drainage ( EUS ‐ BD ) as primary treatment for distal malignant biliary obstruction ( MBO ) is limited. We conducted a meta‐analysis to compare the …
View article: Hyperthermia inhibits the motility of gemcitabine-resistant pancreatic cancer PANC-1 cells through the inhibition of epithelial-mesenchymal transition
Hyperthermia inhibits the motility of gemcitabine-resistant pancreatic cancer PANC-1 cells through the inhibition of epithelial-mesenchymal transition Open
Pancreatic cancer (PC) is one of the most common types of malignant tumor and the leading cause of cancer‑associated mortality worldwide. The chemotherapeutic drug gemcitabine (GEM) is used as a first‑line chemotherapeutic agent for advanc…