Hang‐Jing Wu
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View article: Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of Marfan Syndrome
Enhanced Optic Nerve Expansion and Altered Ultrastructure of Elastic Fibers Induced by Lysyl Oxidase Inhibition in a Mouse Model of Marfan Syndrome Open
View article: Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10
Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10 Open
View article: Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development
Adamts10 controls transforming growth factor β family signaling that contributes to retinal ganglion cell development Open
Although mutations in ADAMTS10 have long been known to cause autosomal recessive Weill-Marchesani Syndrome which is characterized by short stature and ocular abnormalities, more recent work has shown that certain mutations in ADAMTS10 caus…
View article: Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice
Lysyl oxidase-like 1 deficiency alters ultrastructural and biomechanical properties of the peripapillary sclera in mice Open
View article: Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of <i>Adamts10</i>
Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of <i>Adamts10</i> Open
Adamts10G661R/G661R mice recapitulate the short stature and ocular phenotypes of WMS. The altered fibrillin-1 and fibrillin-2 immunoactivity in Adamts10G661R/G661R mice suggests that the G661R mutation of Adamts10 perturbs regulation of th…
View article: Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice
Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice Open
PURPOSE: To test whether mice with microfibril deficiency due to the Tsk mutation of fibrillin-1 (Fbn1(Tsk/+)) have increased susceptibility to pressure-induced retinal ganglion cell (RGC) degeneration. METHODS: Intraocular pressure (IOP) …
View article: Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma
Telmisartan Reduces Axon Degeneration in Mice With Experimental Glaucoma Open
Elevation of IOP by microbead injection led to loss of RGC axons in vehicle-treated mice that was largely prevented by telmisartan treatment, suggesting a neuroprotective effect of telmisartan.
View article: Reduced number and caliber of optic nerve axons and smaller optic nerves in mice homozygous for a glaucoma-causing mutation in Adamts10
Reduced number and caliber of optic nerve axons and smaller optic nerves in mice homozygous for a glaucoma-causing mutation in Adamts10 Open
View article: Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils
Enlarged Optic Nerve Axons and Reduced Visual Function in Mice with Defective Microfibrils Open
Glaucoma is a leading cause of irreversible vision loss due to retinal ganglion cell (RGC) degeneration that develops slowly with age. Elevated intraocular pressure (IOP) is a significant risk factor, although many patients develop glaucom…
View article: Increased susceptibility to glaucomatous optic nerve damage in microfibril deficient mice
Increased susceptibility to glaucomatous optic nerve damage in microfibril deficient mice Open
View article: Inner Retina Dysfunction in Microfibril Deficient Mice with Low Tension Glaucoma
Inner Retina Dysfunction in Microfibril Deficient Mice with Low Tension Glaucoma Open
View article: Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the <i>I</i><sub>to</sub> Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction
Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the <i>I</i><sub>to</sub> Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction Open
H2S targets the Cys320/Cys529 motif in Kv4.2 to regulate the Ito potassium channels. H2S also shows a potent regularizing effect against fatal arrhythmia in a rat model of myocardial infarction. The study provides the first piece of eviden…