Hangping Yao
YOU?
Author Swipe
View article: Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines
Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines Open
Understanding and enhancing vaccine‐induced immune responses in the elderly population is critical, as they face elevated risks of severe COVID‐19. This work systematically delineates age‐associated alterations in innate and adaptive immun…
View article: CircRNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against MPXV
CircRNA vaccine encoding a chimeric immunogen of B6 and M1 demonstrates robust immune responses against MPXV Open
The mpox outbreak has been declared a Public Health Emergency of International Concern on two occasions, with the status remaining effective, highlighting the urgency of this global health crisis. Developing safe and effective vaccines spe…
View article: Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV
Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV Open
Non-cholesterol sterol metabolism plays a crucial role in immune regulation. However, the non-cholesterol sterol profiles, its association with gut dysbiosis, and its impact on the CD4 + T cell recovery in people living with HIV (PLWH) are…
View article: Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus
Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus Open
The H5 subtype avian influenza viruses (AIVs) pose a major threat to wild fowl and poultry. Additionally, they can overcome the species barrier, inducing human infection, which may become fatal. Thus, the H5 subtype AIVs remain a global pu…
View article: Portable lab-on-a-chip platform enabling multiplex recombinant enzyme polymerase amplification detection of H5/H7/H10 avian influenza virus subtypes
Portable lab-on-a-chip platform enabling multiplex recombinant enzyme polymerase amplification detection of H5/H7/H10 avian influenza virus subtypes Open
The zoonotic nature of influenza pathogens creates substantial health security risks, jeopardizing the welfare of interconnected human and animal ecosystems. The H5/H7/H10 avian influenza virus (AIV) variants demonstrate persistent endemic…
View article: Evaluating Bacillus Calmette–Guérin Polysaccharide Nucleic Acid as an Adjuvant for Influenza Vaccines in Mice
Evaluating Bacillus Calmette–Guérin Polysaccharide Nucleic Acid as an Adjuvant for Influenza Vaccines in Mice Open
Background To enhance influenza vaccine efficacy, it is essential to investigate new adjuvants that are both safe and effective. In a recent study utilizing a mouse model, Bacillus Calmette–Guérin polysaccharide nucleic acid (BCG‐PSN) emer…
View article: A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes
A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes Open
Unlike the human-infecting H10N3 and H10N8 AIVs acquiring six internal protein-coding genes from H9N2 AIVs in domestic poultry, the human-infecting H10N5 AIV was generated through multiple reassortments among viruses mainly carried by wild…
View article: Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity Open
The bivalent nature of IgG enhances its neutralization potency against enveloped viruses; however, on-virion structural details of IgG bivalent binding with antigens remain elusive. Here we used cryo-ET to investigate how two potent IgGs P…
View article: Development of a graphene oxide multilayer quantum dot-based immunochromatographic strip for the ultrasensitive detection of H7 subtype avian influenza viruses
Development of a graphene oxide multilayer quantum dot-based immunochromatographic strip for the ultrasensitive detection of H7 subtype avian influenza viruses Open
Since March 2013, the H7N9 subtype of avian influenza virus (AIV) has become an important zoonotic infectious disease, garnering significant global attention because of its potential to affect human health. Establishing a rapid, effective,…
View article: Humanized dual-targeting antibody–drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity
Humanized dual-targeting antibody–drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity Open
Cancer heterogeneity, characterized by diverse populations of tumorigenic cells, involves the occurrence of differential phenotypes with variable expressions of receptor tyrosine kinases. Aberrant expressions of mesenchymal–epithelial tran…
View article: Rapid and Sensitive Quantum Dots Immunochromatographic Strip for H10 Subtype Avian Influenza Virus Detection
Rapid and Sensitive Quantum Dots Immunochromatographic Strip for H10 Subtype Avian Influenza Virus Detection Open
The H10 subtype avian influenza virus (AIV), an important zoonotic pathogen, is widely prevalent in host species (wild fowl) and continues to infect humans, imposing a huge threat to public health. Thus, the H10 subtype AIV is considered a…
View article: China’s Malaria R&D Innovations: A Scoping Review from 2013–2023
China’s Malaria R&D Innovations: A Scoping Review from 2013–2023 Open
Malaria remains a major global health challenge. Understanding the research progress of the potential innovative tools is important for malaria elimination. This scoping review aims to explore China's research and development (R&D;) advanc…
View article: Comparative analysis of hyperuricemia induction methods and probiotic interventions in mice
Comparative analysis of hyperuricemia induction methods and probiotic interventions in mice Open
Probiotics are widely used as functional food additives, but more studies are needed for their use in mitigation of hyperuricemia (HUA). Currently, there are no standardized animal models for HUA. There is significant variability in the an…
View article: DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides
DRAMP 4.0: an open-access data repository dedicated to the clinical translation of antimicrobial peptides Open
Antimicrobial peptides (AMPs) are potential candidates for treating multidrug-resistant bacterial infections, yet only a small number of them have progressed into clinical trials. The main challenges include the poor stability and hemolyti…
View article: Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV
Correlation of Oral Microbiota With Different Immune Responses to Antiretroviral Therapy in People Living With HIV Open
Both HIV infection and antiretroviral therapy (ART) affect the oral microbiome. Whether successful treatment with ART in people living with HIV (PLWH), which leads to a significant decline in viral loads and immune reconstitution, is assoc…
View article: Host proteins interact with viral elements and affect the life cycle of highly pathogenic avian influenza A virus H7N9
Host proteins interact with viral elements and affect the life cycle of highly pathogenic avian influenza A virus H7N9 Open
Host-virus interactions can significantly impact the viral life cycle and pathogenesis; however, our understanding of the specific host factors involved in highly pathogenic avian influenza A virus H7N9 (HPAI H7N9) infection is currently r…
View article: Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2
Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2 Open
RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion …
View article: HSC70，HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Chaperone-Mediated Autophagy
HSC70，HSPA1A, and HSP90AB1 Facilitate Ebola Virus trVLPs to Induce Chaperone-Mediated Autophagy Open
Background Ebola virus (EBOV) can induce autophagy to benefit the virus life cycle, but detailed mechanisms remain to be elucidated. We previously found that EBOV GP and VP40 proteins interact with host chaperones, including HSC70 (HSPA8),…
View article: Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2 Open
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infection, is effective against SAR…
View article: In situ architecture and membrane fusion of SARS-CoV-2 Delta variant
In situ architecture and membrane fusion of SARS-CoV-2 Delta variant Open
Among the current five Variants of Concern, infections caused by SARS-CoV-2 B.1.617.2 (Delta) variant are often associated with the greatest severity. Despite recent advances on the molecular basis of elevated pathogenicity using recombina…
View article: A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses
A multiplex TaqMan real-time RT-PCR assay for the simultaneous detection of H4, H6, and H10 avian influenza viruses Open
Avian influenza viruses (AIVs) have caused a large number of epidemics in domestic and wild birds, and even posed a health challenge to humans. Highly pathogenic AIVs have attracted the most public attention. However, low pathogenic AIVs, …
View article: Immune interference in effectiveness of influenza and COVID-19 vaccination
Immune interference in effectiveness of influenza and COVID-19 vaccination Open
Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and po…
View article: Supplementary Figure 5 from RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE
Supplementary Figure 5 from RON Receptor Tyrosine Kinase as a Therapeutic Target for Eradication of Triple-Negative Breast Cancer: Efficacy of Anti-RON ADC Zt/g4-MMAE Open
Fig. S5 is about the effect of Zt/g4-MMAE on tumor weight and number.
View article: Supplementary Figure 3 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Supplementary Figure 3 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents Open
PDF file - 59K, Figure S3: Effect of PHA665752, Compound-I, and BMS-777607 on induction of polyploidy in breast cancer cells.
View article: Supplementary Table 2 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents
Supplementary Table 2 from Small-Molecule Inhibitor BMS-777607 Induces Breast Cancer Cell Polyploidy with Increased Resistance to Cytotoxic Chemotherapy Agents Open
PDF file - 57K, Supplementary Table 2 Increased resistance of BMS-777607-induced breast cancer polyploid cells in response to cytotoxic chemotherapy agents.