Huimin Wu
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View article: U-Shaped Relationship of Serum Albumin and Neurological Functional Outcomes After Acute Ischemic Stroke: A Prospective Cohort Study
U-Shaped Relationship of Serum Albumin and Neurological Functional Outcomes After Acute Ischemic Stroke: A Prospective Cohort Study Open
Among patients with AIS, there was a U-shaped relationship between SA levels at admission and the likelihood of poor outcomes, which was partially mediated by LDL. There is a Graphical Abstract available for this article.
View article: A Mini Review of Research Trends of Phytoplankton in Chinese Reservoirs: Based on CiteSpace’s Analysis of Bibliometrics
A Mini Review of Research Trends of Phytoplankton in Chinese Reservoirs: Based on CiteSpace’s Analysis of Bibliometrics Open
This study employs bibliometric analysis and knowledge mapping to examine trends in research on phytoplankton in Chinese reservoirs from 2004 to 2024. Utilizing the Web of Science Core Collection Database, the analysis focuses on studies r…
View article: Decadal Extreme Precipitation Anomalies and Associated Multiple Large-Scale Climate Driving Forces in the Three Gorges Reservoir Area, China
Decadal Extreme Precipitation Anomalies and Associated Multiple Large-Scale Climate Driving Forces in the Three Gorges Reservoir Area, China Open
Identifying the relationship between extreme precipitation (EP) and large-scale climate circulation is of great significance for extreme weather management and warning. Previous studies have effectively revealed the influence of single cli…
View article: Integrating network pharmacology and animal experimental validation to investigate the mechanism of lotus leaf in obesity
Integrating network pharmacology and animal experimental validation to investigate the mechanism of lotus leaf in obesity Open
Lotus leaf ameliorates obesity through several pathways, including by downregulating FGF15 and FXR, providing a novel basis for the development of natural drug therapy for obesity.
View article: Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis
Network Pharmacology Analysis and Machine-Learning Models Confirmed the Ability of YiShen HuoXue Decoction to Alleviate Renal Fibrosis by Inhibiting Pyroptosis Open
YSHXD exerts important anti-inflammatory and anti-cellular inflammatory necrosis effects by inhibiting the NLRP3/caspase-1/GSDMD-mediated pyroptosis pathway, indicating that YSHXD represents a new strategy and complementary approach to RF …
View article: Study on the Absorption of Arsenic Species in Realgar Based on the Form and Valence
Study on the Absorption of Arsenic Species in Realgar Based on the Form and Valence Open
At present, several experiments have been carried out to study the changes in total arsenic content of realgar and its prescription, but few researches on its form and valence. We evaluated the change in arsenic species concentration in re…
View article: Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers
Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers Open
The incidence of ocular surface disease (OSD) is increasing, with a trend towards younger ages. However, it is difficult for drugs to reach the deep layers of the cornea due to ocular surface barriers, and bioavailability is less than 5%. …
View article: Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway
Catalpol Protects ARPE-19 Cells against Oxidative Stress via Activation of the Keap1/Nrf2/ARE Pathway Open
Oxidative damage to retinal pigment epithelial (RPE) has been identified as one of the major regulatory factors in the pathogenesis of age-related macular degeneration (AMD). Catalpol is an iridoid glucoside compound that has been found to…
View article: Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease
Topical Delivery of Levocarnitine to the Cornea and Anterior Eye by Thermosensitive in-situ Gel for Dry Eye Disease Open
The LCTG has a good curative effect on mice with DED, and the overall curative effect is better than that of levocarnitine solution.
View article: Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease
Study on the potential effective ingredients of Xiaosheng prescription for dry eye disease Open
Xiaosheng prescription (XSP) has been used for dry eye disease (DED) for more than 10 years in Eye Hospital of China Academy of Chinese Medicine Sciences. However, the effective ingredients involved have remained unclear, which was investi…
View article: Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review
Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review Open
Although experimental data supports the beneficial effects of this compound, acetylshikonin cannot be considered as a therapy drug without further investigations, especially, on the toxicity and pharmacokinetics.
View article: Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior
Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior Open
Metal organic frameworks (MOFs) are widely used in drug carrier research due to their tunability.
View article: A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin
A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin Open
Curcumin (Cur) is a naturally hydrophobic polyphenol with potential pharmacological properties. However, the poor aqueous solubility and low bioavailability of curcumin limits its ocular administration. Thus, the aim of this study was to p…
View article: Hypoxia regulates stemness of breast cancer MDA-MB-231 cells
Hypoxia regulates stemness of breast cancer MDA-MB-231 cells Open
Human breast cancers include cancer stem cell populations as well as non-tumorigenic cancer cells. Breast cancer stem cells possess self-renewal capability and thus are the root cause of recurrence and metastasis of malignant tumors. Hypox…
View article: Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells
Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells Open
Intracranial hemorrhage remains the most feared complication in tissue plasminogen activator (tPA) thrombolysis for ischemic stroke. However, the underlying molecular mechanisms are still poorly elucidated. In this study, we reported an im…