Hani N. Alsafadi
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View article: Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models Open
View article: Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids
Modeling fibrotic alveolar transitional cells with pluripotent stem cell-derived alveolar organoids Open
Repeated injury of the lung epithelium is proposed to be the main driver of idiopathic pulmonary fibrosis (IPF). However, available therapies do not specifically target the epithelium and human models of fibrotic epithelial damage with sui…
View article: Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations
Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations Open
The respiratory epithelium consists of multiple, functionally distinct cell types and is maintained by regionally specific progenitor populations that repair the epithelium following injury. Several in vitro methods exist for studying lung…
View article: Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations
Simultaneous isolation of proximal and distal lung progenitor cells from individual mice using a 3D printed guide reduces proximal cell contamination of distal lung epithelial cell isolations Open
Summary The respiratory epithelium consists of multiple, functionally distinct cell-types and is maintained by regionally-specific progenitor populations which repair the epithelium following injury. Several in vitro methods exist for stud…
View article: Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics
Phenotypic drug screening in a human fibrosis model identified a novel class of antifibrotic therapeutics Open
Innovative high-content screening platform identified N -(2-butoxyphenyl)-3-(phenyl)acrylamides as novel antifibrotics.
View article: Highlights of the ERS Lung Science Conference and Sleep and Breathing Conference 2021 and the new ECMC members
Highlights of the ERS Lung Science Conference and Sleep and Breathing Conference 2021 and the new ECMC members Open
This article provides a brief description of some of the most remarkable sessions of the @EuroRespSoc Lung Science Conference and the Sleep and Breathing Conference 2021 and presents the new incoming members of the ECMC (@EarlyCareerERS…
View article: Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung
Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung Open
View article: Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue
Extracellular‐Matrix‐Reinforced Bioinks for 3D Bioprinting Human Tissue Open
Recent advances in 3D bioprinting allow for generating intricate structures with dimensions relevant for human tissue, but suitable bioinks for producing translationally relevant tissue with complex geometries remain unidentified. Here, a …
View article: Inhibition of LTβR signalling activates WNT-induced regeneration in lung
Inhibition of LTβR signalling activates WNT-induced regeneration in lung Open
View article: Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019 Open
A workshop entitled “Stem Cells, Cell Therapies and Bioengineering in Lung Biology and Diseases” was hosted by the University of Vermont Larner College of Medicine in collaboration with the National Heart, Lung and Blood Institute, the Alp…
View article: Isolation of high yield and quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts
Isolation of high yield and quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts Open
Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung biology and disease, as well as for screening novel therapeutics. In particular, PCLS derived from human tissue can better recapitulate some aspects …
View article: Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery
Applications and Approaches for Three-Dimensional Precision-Cut Lung Slices. Disease Modeling and Drug Discovery Open
Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and impose major health and financial burdens on patients and socie…
View article: Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling
Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling Open
Translation of novel discoveries to human disease is limited by the availability of human tissue-based models of disease. Precision-cut lung slices (PCLS) used as 3D lung tissue cultures (3D-LTCs) represent an elegant and biologically high…
View article: Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis Open
View article: Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis
Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis Open
View article: Early Career Members at the ERS Lung Science Conference: cell-matrix interactions in lung disease and regeneration
Early Career Members at the ERS Lung Science Conference: cell-matrix interactions in lung disease and regeneration Open
.@EarlyCareerERS looks back on #LSC2018 http://ow.ly/6hjS30jB6P9.
View article: Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis<i>ex vivo</i>
Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis<i>ex vivo</i> Open
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and limited therapeutic options. The incidence of IPF increases with age, and ageing-related mechanisms such as cellular senescence have been proposed as…
View article: An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices
An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices Open
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic interstitial lung disease (ILD) characterized by lung tissue scarring and high morbidity. Lung epithelial injury, myofibroblast activation, and deranged repair are believed to be…