Hanjiang Fu
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View article: Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells
Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells Open
Ferroptosis, a recently discovered type of programmed cell death triggered by excessive accumulation of iron‑dependent lipid peroxidation, is linked to several malignancies, including non‑small cell lung cancer. Long non‑coding RNAs (lncRN…
View article: Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation
Unraveling the Role of RNase L Knockout in Alleviating Immune Response Activation in Mice Bone Marrow after Irradiation Open
Ionizing radiation (IR) induces severe hematopoietic injury by causing DNA and RNA damage as well as activating the immune responses, necessitating the development of effective therapeutic strategies. Ribonuclease L (RNase L) as an innate …
View article: Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation‐Induced Lung Injury
Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation‐Induced Lung Injury Open
Radiation‐induced lung injury (RILI) is frequently observed in patients undergoing radiotherapy for thoracic malignancies, constituting a significant complication that hampers the effectiveness and utilization of tumor treatments. Ionizing…
View article: Toll-like Receptor Agonist CBLB502 Protects Against Radiation-induced Intestinal Injury in Mice
Toll-like Receptor Agonist CBLB502 Protects Against Radiation-induced Intestinal Injury in Mice Open
This study preliminarily describes the regulatory mechanism of IR-induced intestinal injury and the potential molecular protective mechanism of CBLB502, providing a basis for identifying the functional genes and molecular mechanisms that m…
View article: Data from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Data from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
The extracellular matrix (ECM) is a determining factor in the tumor microenvironment that restrains or promotes malignant growth. In this report, we show how the molecular chaperone protein Hsp47 functions as a nodal hub in regulating an E…
View article: Supplemental Figure S3 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S3 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S3. Hsp47 expression is associated with poor prognosis and contributes to the deposition of ECM proteins in breast cancer tissue.
View article: Supplemental Figure S2 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S2 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S2. MiR-29 is a potential regulator of multiple ECM network genes.
View article: Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Table and Figure Legends. Legends for Supplemental Table S1 and Supplemental Figures S1-S4.
View article: Data from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Data from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
The extracellular matrix (ECM) is a determining factor in the tumor microenvironment that restrains or promotes malignant growth. In this report, we show how the molecular chaperone protein Hsp47 functions as a nodal hub in regulating an E…
View article: Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S1. Hsp47 expression is upregulated in various cancers, but the upregulation is not sufficient to induce transformation.
View article: Supplemental Table S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Table S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Table S1. Expression of Hsp47 and ECM protein genes is correlated in mammary cell lines.
View article: Supplemental Figure S3 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S3 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S3. Hsp47 expression is associated with poor prognosis and contributes to the deposition of ECM proteins in breast cancer tissue.
View article: Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Table and Figure Legends. Legends for Supplemental Table S1 and Supplemental Figures S1-S4.
View article: Supplemental Figure S2 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S2 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S2. MiR-29 is a potential regulator of multiple ECM network genes.
View article: Supplemental Table S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Table S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Table S1. Expression of Hsp47 and ECM protein genes is correlated in mammary cell lines.
View article: Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S4. Increased Hsp47 expression has been detected in ER negative cancer and is negatively associated with GATA3 levels.
View article: Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S4. Increased Hsp47 expression has been detected in ER negative cancer and is negatively associated with GATA3 levels.
View article: Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Supplemental Figure S1 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network Open
Supplemental Figure S1. Hsp47 expression is upregulated in various cancers, but the upregulation is not sufficient to induce transformation.
View article: Toll-like Receptor Agonist CBLB502 Protects Against Cisplatin-induced Liver and Kidney Damage in Mice
Toll-like Receptor Agonist CBLB502 Protects Against Cisplatin-induced Liver and Kidney Damage in Mice Open
Our data provide insights into the protective mechanism of CBLB502 against CDDP-induced tissue damage in the liver and kidney and might provide a basis for future studies on functional genes and regulatory mechanisms that mediate protectio…
View article: Identification of Combinations of Plasma lncRNAs and mRNAs as Potential Biomarkers for Precursor Lesions and Early Gastric Cancer
Identification of Combinations of Plasma lncRNAs and mRNAs as Potential Biomarkers for Precursor Lesions and Early Gastric Cancer Open
Patients with gastric cancer (GC) are usually first diagnosed at an advanced stage due to the absence of obvious symptoms at an early GC (EGC) stage. Therefore, it is necessary to identify an effective screening method to detect precursor …
View article: Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells
Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells Open
Pyroptosis is mediated by gasdermins and serves a critical role in ionizing radiation (IR)‑induced damage in normal tissues, but its role in cancer radiotherapy and underlying mechanisms remains unclear. Long non‑coding (lnc) RNAs serve im…
View article: Genome-wide analysis of lncRNA stability in human
Genome-wide analysis of lncRNA stability in human Open
Transcript stability is associated with many biological processes, and the factors affecting mRNA stability have been extensively studied. However, little is known about the features related to human long noncoding RNA (lncRNA) stability. …
View article: Plasma Proteins As Biodosimetric Markers of Low-Dose Radiation in Mice
Plasma Proteins As Biodosimetric Markers of Low-Dose Radiation in Mice Open
Long-term exposures to low-dose radiation (LDR) may trigger several specific biological responses, including dysregulation of the immune and inflammatory systems. Here, we examined whether biodosimetry of LDR can be used to protect tissues…
View article: RNA Profiling Reveals a Common Mechanism of Histone Gene Downregulation and Complementary Effects for Radioprotectants in Response to Ionizing Radiation
RNA Profiling Reveals a Common Mechanism of Histone Gene Downregulation and Complementary Effects for Radioprotectants in Response to Ionizing Radiation Open
High-dose ionizing radiation (IR) alters the expression levels of non-coding RNAs (ncRNAs). However, the roles of ncRNAs and mRNAs in mediating radiation protection by radioprotectants remain unknown. Microarrays were used to determine mic…
View article: Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice
Plasma Proteins as Biomarkers of Mortality After Total Body Irradiation in Mice Open
During large-scale acute radiation exposure, rapidly distinguishing exposed individuals from nonexposed individuals is necessary. Identifying those exposed to high and potentially lethal radiation doses, and in need of immediate treatment,…
View article: <scp>RN</scp>ase L facilitates the repair of <scp>DNA</scp> double‐strand breaks through the nonhomologous end‐joining pathway
<span>RN</span>ase L facilitates the repair of <span>DNA</span> double‐strand breaks through the nonhomologous end‐joining pathway Open
RNA molecules have been found to play important roles in DNA double‐strand break ( DSB ) repair, but the exact underlying mechanism remains unclear. Here, we aimed to clarify the function of RN ase L, an important ribonuclease in the immun…
View article: Identification of plasma RGS18 and PPBP mRNAs as potential biomarkers for gastric cancer using transcriptome arrays
Identification of plasma RGS18 and PPBP mRNAs as potential biomarkers for gastric cancer using transcriptome arrays Open
Coding and noncoding RNAs serve a crucial role in tumorigenesis. Circulating RNAs have been recognized as a novel category of biomarkers for a variety of physiological and pathological conditions. To identify plasma RNA biomarkers for gast…
View article: Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions
Transcriptional activation of miR-320a by ATF2, ELK1 and YY1 induces cancer cell apoptosis under ionizing radiation conditions Open
MicroRNAs (miRNAs or miRs) play important roles in numerous cellular processes, including development, proliferation, tumorigenesis and apoptosis. It has been reported that miRNA expression is induced by ionizing radiation (IR) in cancer c…
View article: SERS detection of radiation injury biomarkers in mouse serum
SERS detection of radiation injury biomarkers in mouse serum Open
A rapid and on-site detection method would be needed to triage of casualties and proper medical treatment in a large scale radiological catastrophe. The detection method of SERS would be a effective approach.
View article: Detecting RNA-RNA interactions in E. coli using a modified CLASH method
Detecting RNA-RNA interactions in E. coli using a modified CLASH method Open
Discovery of novel RNA-RNA interactions in the present study demonstrates that RNA-RNA interactions might be far more complicated than ever expected. New methods may be required to help discover more novel RNA-RNA interactions. The present…