Hanjun Zhao
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View article: Prognostic impacts of lipoxin A4 in relation to diabetes and insulin resistance in patients with acute myocardial infarction: a prospective study
Prognostic impacts of lipoxin A4 in relation to diabetes and insulin resistance in patients with acute myocardial infarction: a prospective study Open
In patients with AMI, ischemic risk reduction associated with high LXA4 levels is attenuated by DM and IR.
View article: The association between mosaic loss of Y chromosome and mortality in patients with ST-segment elevation myocardial infarction: A prospective cohort study
The association between mosaic loss of Y chromosome and mortality in patients with ST-segment elevation myocardial infarction: A prospective cohort study Open
Objective While loss of Y chromosome (LOY) has been associated with cardiovascular diseases, its specific impact on ST-segment elevation myocardial infarction (STEMI) remains underexplored. This study aimed to investigate the impact of LOY…
View article: Traditional Chinese medicine Yiqi Huoxue Huatan recipe inhibits atherosclerosis by regulating intestinal flora and its associated metabolites
Traditional Chinese medicine Yiqi Huoxue Huatan recipe inhibits atherosclerosis by regulating intestinal flora and its associated metabolites Open
Background: Yiqi Huoxue Huatan recipe (YHHR) has been shown to possess anti-atherosclerotic effects, as detailed in various studies and clinical observations. However, the potential mechanism underlying atherosclerosis remains unclear. Thi…
View article: Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study
Elevated Circulating Adipocyte-Fatty Acid Binding Protein Levels Predict Incident Ischemic Cardiovascular Events in a Longitudinal and Prospective AMI Aging Study Open
This study reinforces the utility of FABP4 for enhancing risk stratification specifically among older patients diagnosed with ST-elevation myocardial infarction.
View article: Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization
Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization Open
CHIP mutations, particularly TET2, are more prevalent in patients with T2DM compared to individuals without diabetes. The presence of these mutations is associated with adverse clinical outcomes, notably increased mortality rates. Moreover…
View article: Removal of an entrapped guidewire by excimer laser coronary angioplasty in patients with chronic total occlusion intervention
Removal of an entrapped guidewire by excimer laser coronary angioplasty in patients with chronic total occlusion intervention Open
View article: Outcomes of Optical Coherence Tomography-Guided and Angiography-Guided Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction
Outcomes of Optical Coherence Tomography-Guided and Angiography-Guided Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction Open
Background: Despite the administration of timely reperfusion treatment, patients with acute myocardial infarction have a high mortality rate and poor prognosis. The potential impact of intraluminal imaging guidance, such as optical coheren…
View article: Woven coronary artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography
Woven coronary artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography Open
View article: Woven Coronary Artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography
Woven Coronary Artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography Open
Woven coronary artery (WCA) is a rare anomaly and its etiology remains speculative. Both congenital and acquired factors are considered to be concerned with the pathogenesis. In a 35-year-old man, the tissue characteristics of WCA were eva…
View article: A Prospective Study in Evaluating Clinical Utility of Novel Lipid Parameters and TyG index for Risk Stratification in Diabetes Mellitus Patients with STEMI
A Prospective Study in Evaluating Clinical Utility of Novel Lipid Parameters and TyG index for Risk Stratification in Diabetes Mellitus Patients with STEMI Open
Background Abnormal glucose and lipid metabolism are very commonplace in individuals with myocardial infarction, while insulin resistance plays a vital role in this biological process. Nevertheless, cardiovascular risk estimation by novel …
View article: A Combined Measure of the Triglyceride Glucose Index and Trimethylamine N-Oxide in Risk Stratification of ST-Segment Elevation Myocardial Infarction Patients with High-Risk Plaque Features Defined by Optical Coherence Tomography: A Substudy of the OCTAMI Registry Study
A Combined Measure of the Triglyceride Glucose Index and Trimethylamine N-Oxide in Risk Stratification of ST-Segment Elevation Myocardial Infarction Patients with High-Risk Plaque Features Defined by Optical Coherence Tomography: A Substudy of the OCTAMI Registry Study Open
This study was registered at ClinicalTrials.gov as NCT03593928.
View article: Prospect of research on anti-atherosclerosis effect of main components of traditional Chinese medicine Yiqi Huoxue Huatan recipe through gut microbiota: A review
Prospect of research on anti-atherosclerosis effect of main components of traditional Chinese medicine Yiqi Huoxue Huatan recipe through gut microbiota: A review Open
The incidence and mortality rates of cardiovascular diseases are on the rise globally, posing a severe threat to human health. Atherosclerosis (AS) is considered a multi-factorial inflammatory disease and the main pathological basis of car…
View article: Associations Between Resolvin D1 and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients with ST-Segment Elevation Myocardial Infarction
Associations Between Resolvin D1 and Culprit Plaque Morphologies: An Optical Coherence Tomography Study in Patients with ST-Segment Elevation Myocardial Infarction Open
Increased levels of RvD1 were associated with higher instability of coronary atherosclerotic plaques in STEMI patients.
View article: Lipid Content Distribution and its Clinical Implication in Patients with Acute Myocardial Infarction-Plaque Erosion: Results from the Prospective OCTAMI Study
Lipid Content Distribution and its Clinical Implication in Patients with Acute Myocardial Infarction-Plaque Erosion: Results from the Prospective OCTAMI Study Open
This study revealed that high level of lipid content in the proximal external erosion zone was related to high-risk plaque characteristics and poor prognosis, which provided a novel method for risk stratification and precise management in …
View article: Associations of Culprit Vessel Size and Plaque Characteristics in Patients with ST-Segment Elevation Myocardial Infarction
Associations of Culprit Vessel Size and Plaque Characteristics in Patients with ST-Segment Elevation Myocardial Infarction Open
Background: Small vessel disease (SVD) widely exists in patients with acute coronary syndrome. However, the plaque characteristic of SVD has not been investigated. Methods: Optical coherence tomography (OCT) of culprit lesion was examined …
View article: Prognostic impacts of diabetes status and lipoprotein(a) levels in patients with ST-segment elevation myocardial infarction: a prospective cohort study
Prognostic impacts of diabetes status and lipoprotein(a) levels in patients with ST-segment elevation myocardial infarction: a prospective cohort study Open
View article: ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ.
ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ. Open
Our experimental data speculate that ANGPTL4 is a key factor in regulating AF progression. Therefore, increasing ANGPTL4 expression could be an effective strategy for AF treatment.
View article: Effect of Triglyceride-Glucose Indices and Circulating PCSK9-Associated Cardiovascular Risk in STEMI Patients with Primary Percutaneous Coronary Artery Disease: A Prospective Cohort Study
Effect of Triglyceride-Glucose Indices and Circulating PCSK9-Associated Cardiovascular Risk in STEMI Patients with Primary Percutaneous Coronary Artery Disease: A Prospective Cohort Study Open
Elevated PCSK9 levels are related to all-cause mortality and cardiac-related mortality when TyG levels are greater than the median, but not when levels are less than the median. This suggests a potential benefit of lowering circulating PCS…
View article: The Impacts of Percutaneous Coronary Intervention to Treat Chronic Total Occlusion of Right Coronary Artery on the 5-Year Prognosis: A Single-Centered Retrospective Study
The Impacts of Percutaneous Coronary Intervention to Treat Chronic Total Occlusion of Right Coronary Artery on the 5-Year Prognosis: A Single-Centered Retrospective Study Open
View article: Prognostic impacts of Lipoxin A4 in patients with acute myocardial infarction: A prospective cohort study
Prognostic impacts of Lipoxin A4 in patients with acute myocardial infarction: A prospective cohort study Open
Lipoxin A4 (LXA4) is one of the specialized pro-resolving lipid mediators proved to suppress the progression of atherosclerosis in vivo, but its clinical impacts in atherosclerotic patients is unclear. In this study, we assessed the progno…
View article: Prognostic Value of Admission Peak NT-proBNP Combined with Culprit Plaque Types for Predicting Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study
Prognostic Value of Admission Peak NT-proBNP Combined with Culprit Plaque Types for Predicting Cardiovascular Risk in ST-Segment Elevated Myocardial Infarction: An Optical Coherence Tomography Study Open
Objective: Different culprit plaque phenotypes including plaque rupture (PR) and non-plaque rupture (NPR), and N-Terminal prohormone of brain natriuretic peptide (NT-proBNP) have been reported to influence clinical outcomes in patients wit…
View article: Association between the Changes in Trimethylamine N-Oxide-Related Metabolites and Prognosis of Patients with Acute Myocardial Infarction: A Prospective Study
Association between the Changes in Trimethylamine N-Oxide-Related Metabolites and Prognosis of Patients with Acute Myocardial Infarction: A Prospective Study Open
This study aimed to investigate the association between changes in levels of trimethylamine N-oxide (TMAO) and its precursors and the prognosis of patients with acute myocardial infarction (AMI). Patients diagnosed with AMI were prospectiv…
View article: Long-term Management of Patients with Myocardial Infarction: An Updated Review
Long-term Management of Patients with Myocardial Infarction: An Updated Review Open
The outcomes of patients with myocardial infarction (MI) have substantially improved given the rapid progress that has occurred in revascularization techniques and secondary prevention, and the majority of MI patients subsequently enter a …
View article: Association between waist circumference change and incident chronic obstructive pulmonary disease among Chinese adults: a 10-year cohort study
Association between waist circumference change and incident chronic obstructive pulmonary disease among Chinese adults: a 10-year cohort study Open
View article: Prognostic Impacts of LL-37 in Relation to Lipid Profiles of Patients with Myocardial Infarction: A Prospective Cohort Study
Prognostic Impacts of LL-37 in Relation to Lipid Profiles of Patients with Myocardial Infarction: A Prospective Cohort Study Open
Background. In vivo studies show that LL-37 inhibits the progression of atherosclerosis and predicts a lower risk of recurrent ischemia in patients with acute myocardial infarction (AMI), which could be mediated by the modulation of lipid …
View article: Development and Validation of a Prediction Rule for Major Adverse Cardiac and Cerebrovascular Events in High-Risk Myocardial Infarction Patients After Primary Percutaneous Coronary Intervention
Development and Validation of a Prediction Rule for Major Adverse Cardiac and Cerebrovascular Events in High-Risk Myocardial Infarction Patients After Primary Percutaneous Coronary Intervention Open
The predicted model was internally validated and calibrated in large cohorts of patients with high-risk MI receiving primary PCI to predict MACCE and showed modest accuracy in the derivation and validation cohorts.
View article: Association between trimethylamine N‐oxide and prognosis of patients with acute myocardial infarction and heart failure
Association between trimethylamine N‐oxide and prognosis of patients with acute myocardial infarction and heart failure Open
Aims This study aimed to investigate the association between trimethylamine N‐oxide (TMAO) and the prognosis and association between high‐sensitivity C‐reactive protein (hsCRP) and TMAO‐associated cardiovascular risk in patients with acute…
View article: Therapeutic Targeting of Interleukin-11 Up-Regulated Angiotensin II Induced Atrial Fibrosis in Mice
Therapeutic Targeting of Interleukin-11 Up-Regulated Angiotensin II Induced Atrial Fibrosis in Mice Open
Purpose Inflammatory cytokines are closely associated with developing cardiac fibrosis. This research aimed to explore the significant role of IL-11 in atrial fibrosis progression and potential therapeutic targets. Methods 367 subjects wer…
View article: Association of PCSK9 with inflammation and platelet activation markers and recurrent cardiovascular risks in STEMI patients undergoing primary PCI with or without diabetes
Association of PCSK9 with inflammation and platelet activation markers and recurrent cardiovascular risks in STEMI patients undergoing primary PCI with or without diabetes Open
Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to be predictive of cardiovascular outcomes in stable coronary artery disease with diabetes. We aimed to assess the relationship between PCSK9 and major advers…
View article: Prognostic Impacts of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Coronary Syndrome Patients Without Heart Failure
Prognostic Impacts of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Acute Coronary Syndrome Patients Without Heart Failure Open
Background: Despite the recommendations from mainstream guidelines, the use of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) for acute coronary syndrome (ACS) patients without heart failure (HF) is…