Explanipedia

Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke Open

Ke Song, Yikun Sun, Haoqi Liu, Yuanyuan Li, Na An , et al. · 2022

Aim. To elucidate the mechanism of action of berberine on ischaemic stroke based on network pharmacology, bioinformatics, and experimental verification. Methods. Berberine-related long noncoding RNAs (lncRNAs) were screened from public dat…

Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases Open

Ke Song, Yuanyuan Li, Hanlai Zhang, Na An, Yufei Wei , et al. · 2020

The blood-brain barrier (BBB), as a crucial gate of brain-blood molecular exchange, is involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused by an imbalance between the production of reactive oxygen spe…

Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation Open

Xinyu Yang, Na An, Changming Zhong, Manke Guan, Yuchen Jiang , et al. · 2020

Efficacy and Safety of NaoShuanTong Capsule in the Treatment of Ischemic Stroke: A Meta-Analysis Open

Hanlai Zhang, Yanwei Xing, Jingling Chang, Liqin Wang, Na An , et al. · 2019

Background: Ischemic stroke (IS) is a leading cause of death and long-term disability worldwide. The NaoShuanTong capsule (NSTC), a traditional Chinese patent medicine, has been extensively used in the treatment of stroke in China. …

Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases Open

Na An, Yonghong Gao, Zeyu Si, Hanlai Zhang, Liqin Wang , et al. · 2019

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce dow…

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