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View article: Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility Open
Heritable fragile bone disorders (FBDs), ranging from multifactorial to rare monogenic conditions, are characterized by an elevated fracture risk. Validating causative genes and understanding their mechanisms remain challenging. We assesse…
View article: Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility Open
Heritable Fragile Bone Disorders (FBDs) encompass a spectrum of conditions, from widespread multifactorial to rare monogenic diseases, all characterized by an elevated risk of fractures. The process of validating causative genes and elucid…
View article: <i>Bmpr1aa</i> modulates the severity of the skeletal phenotype in an <i>fkbp10</i>-deficient Bruck syndrome zebrafish model
<i>Bmpr1aa</i> modulates the severity of the skeletal phenotype in an <i>fkbp10</i>-deficient Bruck syndrome zebrafish model Open
Rare monogenic disorders often exhibit significant phenotypic variability among individuals sharing identical genetic mutations. Bruck syndrome (BS), a prime example, is characterized by bone fragility and congenital contractures, although…
View article: Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility Open
Heritable fragile bone disorders (FBDs), ranging from multifactorial to rare monogenic conditions, are characterized by an elevated fracture risk. Validating causative genes and understanding their mechanisms remain challenging. We assesse…
View article: Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility Open
Heritable Fragile Bone Disorders (FBDs) encompass a spectrum of conditions, from widespread multifactorial to rare monogenic diseases, all characterized by an elevated risk of fractures. The process of validating causative genes and elucid…
View article: Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility Open
Heritable Fragile Bone Disorders (FBDs) encompass a spectrum of conditions, from widespread multifactorial to rare monogenic diseases, all characterized by an elevated risk of fractures. The process of validating causative genes and elucid…
View article: Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture
Early mechanisms of aortic failure in a zebrafish model for thoracic aortic dissection and rupture Open
Thoracic aortic aneurysm and dissection (TAAD) associates with a high mortality rate. Despite the existence of different mouse models for TAAD, the underlying disease mechanisms remain elusive. Treatment options are limited and mainly cons…
View article: Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development
Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development Open
SNARE proteins comprise a conserved protein family responsible for catalyzing membrane fusion during vesicle traffic. Syntaxin18 (STX18) is a poorly characterized endoplasmic reticulum (ER)-resident t-SNARE. Recently, together with TANGO1 …
View article: Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes
Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR-based functional screening of osteoporosis candidate genes Open
Genomewide association studies (GWAS) have improved our understanding of the genetic architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute functional skeletal contributions of candidate genes to osteoporo…
View article: Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes
Lrp5 Mutant and Crispant Zebrafish Faithfully Model Human Osteoporosis, Establishing the Zebrafish as a Platform for CRISPR-Based Functional Screening of Osteoporosis Candidate Genes Open
Genomewide association studies (GWAS) have improved our understanding of the genetic architecture of common complex diseases such as osteoporosis. Nevertheless, to attribute functional skeletal contributions of candidate genes to osteoporo…
View article: CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments
CRISPR/Cas9-mediated homology-directed repair by ssODNs in zebrafish induces complex mutational patterns resulting from genomic integration of repair-template fragments Open
Targeted genome editing by CRISPR/Cas9 is extremely well fitted to generate gene disruptions, although precise sequence replacement by CRISPR/Cas9-mediated homology-directed repair (HDR) suffers from low efficiency, impeding its use for hi…
View article: Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies
Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies Open
Significance Type I collagenopathies are a heterogenous group of connective tissue disorders, caused by genetic defects in type I collagen. Inherent to these disorders is a large clinical variability, of which the underlying molecular basi…
View article: Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies
Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies Open
The type I collagenopathies are a group of heterogeneous connective tissue disorders, that are caused by mutations in the genes encoding type I collagen and include specific forms of Osteogenesis Imperfecta (OI) and the Ehlers-Danlos syndr…