Hanna K. Gaggin
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View article: The assessment and management of patients with type 2 myocardial infarction: an international Delphi study
The assessment and management of patients with type 2 myocardial infarction: an international Delphi study Open
Aims Type 2 myocardial infarction due to myocardial oxygen supply–demand imbalance is associated with poor outcomes. There are no guidelines to inform care for these patients. The consensus on the assessment and management of type 2 myocar…
View article: Exploring Backdoor Attacks in Off-the-Shelf Unsupervised Domain Adaptation for Securing Cardiac MRI-Based Diagnosis
Exploring Backdoor Attacks in Off-the-Shelf Unsupervised Domain Adaptation for Securing Cardiac MRI-Based Diagnosis Open
The off-the-shelf model for unsupervised domain adaptation (OSUDA) has been introduced to protect patient data privacy and intellectual property of the source domain without access to the labeled source domain data. Yet, an off-the-shelf d…
View article: Contemporary outpatient management of patients with worsening heart failure with reduced ejection fraction: Clinical outcome results from the CHART-HF study
Contemporary outpatient management of patients with worsening heart failure with reduced ejection fraction: Clinical outcome results from the CHART-HF study Open
View article: Treatment patterns of patients with worsening heart failure with reduced ejection fraction
Treatment patterns of patients with worsening heart failure with reduced ejection fraction Open
Aims Patients with HFrEF and worsening HF events (WHFE) are at particularly high risk and urgently need disease‐modifying therapy. CHART‐HF assessed treatment patterns and reasons for medication decisions among HFrEF patients with and with…
View article: Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm
Wild-type Transthyretin Amyloid Deposition in an Ascending Aortic Aneurysm Open
View article: Comparative effectiveness of GDMT in the prevention of HF morbidity and death among patients with HFrEF in a U.S. database
Comparative effectiveness of GDMT in the prevention of HF morbidity and death among patients with HFrEF in a U.S. database Open
Background The incremental benefit of comprehensive over conventional guideline-directed medical therapy (GDMT) in real-world setting has not been well demonstrated in patients with heart failure with reduced ejection fraction (HFrEF). Thi…
View article: The impact of worsening heart failure (WHF) status on subsequent outcomes among patients with HFrEF: History of WHF events is associated with worse subsequent outcomes regardless of extent of GDMT
The impact of worsening heart failure (WHF) status on subsequent outcomes among patients with HFrEF: History of WHF events is associated with worse subsequent outcomes regardless of extent of GDMT Open
Background Patients with worsening heart failure (WHF) have increased risk of future WHF events and death. Guideline directed medical therapy (GDMT) reduces this risk in clinical trials, but few patients in the real-world receive optimal G…
View article: Successive Subspace Learning for Cardiac Disease Classification with Two-Phase Deformation Fields from Cine MRI
Successive Subspace Learning for Cardiac Disease Classification with Two-Phase Deformation Fields from Cine MRI Open
Cardiac cine magnetic resonance imaging (MRI) has been used to characterize cardiovascular diseases (CVD), often providing a noninvasive phenotyping tool. While recently flourished deep learning based approaches using cine MRI yield accura…
View article: Successive Subspace Learning for Cardiac Disease Classification with Two-phase Deformation Fields from Cine MRI
Successive Subspace Learning for Cardiac Disease Classification with Two-phase Deformation Fields from Cine MRI Open
Cardiac cine magnetic resonance imaging (MRI) has been used to characterize cardiovascular diseases (CVD), often providing a noninvasive phenotyping tool.~While recently flourished deep learning based approaches using cine MRI yield accura…
View article: A Peek Into the Future: Will Serial Multimarker Testing Help Bring a New Era of Precision Medicine in Heart Failure Patients?
A Peek Into the Future: Will Serial Multimarker Testing Help Bring a New Era of Precision Medicine in Heart Failure Patients? Open
View article: Performance of a multi-biomarker panel for prediction of cardiovascular event in patients with chronic kidney disease
Performance of a multi-biomarker panel for prediction of cardiovascular event in patients with chronic kidney disease Open
View article: Biomarker prognostication across Universal Definition of Heart Failure stages
Biomarker prognostication across Universal Definition of Heart Failure stages Open
Aim The Universal Definition of Heart Failure (UDHF) provides a framework for staging risk for HF events. It is not clear whether prognostic biomarkers have different meaning across UDHF stages. We sought to evaluate performance of biomark…
View article: Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection
Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection Open
Background: Novel targeted treatments increase the need for prompt hypertrophic cardiomyopathy (HCM) detection. However, its low prevalence (0.5%) and resemblance to common diseases present challenges that may benefit from automated machin…
View article: Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates
Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates Open
View article: Inflammatory biomarkers and risk of cardiovascular events in patients undergoing coronary angiography
Inflammatory biomarkers and risk of cardiovascular events in patients undergoing coronary angiography Open
View article: Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study
Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study Open
Objectives To evaluate the diagnostic performance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) thresholds for acute heart failure and to develop and validate a decision support tool that combines NT-proBNP concentrations with c…
View article: Contents
Contents Open
View article: A Biomarker‐Enhanced Model for Prediction of Acute Kidney Injury and Cardiovascular Risk Following Angiographic Procedures: CASABLANCA AKI Prediction Substudy
A Biomarker‐Enhanced Model for Prediction of Acute Kidney Injury and Cardiovascular Risk Following Angiographic Procedures: CASABLANCA AKI Prediction Substudy Open
Background The 2020 Acute Disease Quality Initiative Consensus provided recommendations on novel acute kidney injury biomarkers. In this study, we sought to assess the added value of novel kidney biomarkers to a clinical score in the CASAB…
View article: Circulating levels and prognostic cut‐offs of sST2, hs‐cTnT, and NT‐proBNP in women vs. men with chronic heart failure
Circulating levels and prognostic cut‐offs of sST2, hs‐cTnT, and NT‐proBNP in women vs. men with chronic heart failure Open
Aims To define plasma concentrations, determinants, and optimal prognostic cut‐offs of soluble suppression of tumorigenesis‐2 (sST2), high‐sensitivity cardiac troponin T (hs‐cTnT), and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) …
View article: Relation of High-Sensitivity Cardiac Troponin I and Obstructive Coronary Artery Disease in Patients Without Acute Myocardial Infarction
Relation of High-Sensitivity Cardiac Troponin I and Obstructive Coronary Artery Disease in Patients Without Acute Myocardial Infarction Open
View article: Performance of a protein biomarker panel for prediction of cardiovascular events in patients with diabetes mellitus
Performance of a protein biomarker panel for prediction of cardiovascular events in patients with diabetes mellitus Open
Persons with diabetes mellitus (DM) are at increased risk of cardiovascular events (CVEs).1 Pathophysiological processes leading to CVE such as acute myocardial infarction (MI), stroke, or cardiovascular (CV) death may be inherently differ…
View article: Frailty Among Asian Patients With Heart Failure
Frailty Among Asian Patients With Heart Failure Open
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View article: 41 Circulating levels and prognostic cut-offs of sST2, high-sensitivity troponin T, and NT-proBNP in women vs. men with chronic heart failure
41 Circulating levels and prognostic cut-offs of sST2, high-sensitivity troponin T, and NT-proBNP in women vs. men with chronic heart failure Open
Aims Limited evidence exists on sex-related differences in clinical value of biomarkers in chronic heart failure (HF). We aimed to define plasma levels, determinants, and optimal prognostic cut-offs of soluble suppression of tumourigenesis…
View article: Multiple Cardiac Biomarker Testing Among Patients With Acute Dyspnea From the ICON-RELOADED Study
Multiple Cardiac Biomarker Testing Among Patients With Acute Dyspnea From the ICON-RELOADED Study Open
A multimarker panel of NT-proBNP, hsTnT, and IGBFP7 provides unique clinical, diagnostic, and prognostic information in patients presenting with acute dyspnea. Differences in the number of elevated biomarkers at presentation may allow for …
View article: Rationale and design of the preserved versus reduced ejection fraction biomarker registry and precision medicine database for ambulatory patients with heart failure (PREFER-HF) study
Rationale and design of the preserved versus reduced ejection fraction biomarker registry and precision medicine database for ambulatory patients with heart failure (PREFER-HF) study Open
Introduction Patients with heart failure (HF) are classically categorised by left ventricular ejection fraction (LVEF). Efforts to predict outcomes and response to specific therapy among LVEF-based groups may be suboptimal, in part due to …
View article: Additive prognostic value of cardiac biomarkers in patients with chronic obstructive pulmonary disease and heart failure
Additive prognostic value of cardiac biomarkers in patients with chronic obstructive pulmonary disease and heart failure Open
Background Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of 3 HF biomarkers: N-terminal pro-B-type n…
View article: Segmentation of Cardiac Structures via Successive Subspace Learning with Saab Transform from Cine MRI
Segmentation of Cardiac Structures via Successive Subspace Learning with Saab Transform from Cine MRI Open
Assessment of cardiovascular disease (CVD) with cine magnetic resonance imaging (MRI) has been used to non-invasively evaluate detailed cardiac structure and function. Accurate segmentation of cardiac structures from cine MRI is a crucial …
View article: NT-proBNP for Risk Prediction in Heart Failure
NT-proBNP for Risk Prediction in Heart Failure Open
View article: Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms
Artificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms Open
View article: ATTR amyloidosis during the COVID-19 pandemic: insights from a global medical roundtable
ATTR amyloidosis during the COVID-19 pandemic: insights from a global medical roundtable Open