Explanipedia

HLA‐Region Genetic Association Analysis of Breast Cancer Patients With and Without Persistent Postsurgical Neuropathic Pain Open

Laura Mustonen, Janne Nieminen, Satu Koskela, Mari Kaunisto, Eija Kalso , et al. · 2025

Background Surgical nerve injuries lead to persistent neuropathic pain (NP) in up to 30% of patients. Among many other factors, polymorphisms in the human leukocyte antigen (HLA) genes have been suggested to contribute to the development o…

Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1 Open

Jaakko Hotta, Jukka Saari, Hanna Harno, Eija Kalso, Nina Forss , et al. · 2023

In complex regional pain syndrome (CRPS), the representation area of the affected limb in the primary sensorimotor cortex (SM1) reacts abnormally during sensory stimulation and motor actions. We recorded 3T functional magnetic resonance im…

rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring Open

Jukka Vanhanen, Jan Kujala, Mia Liljeström, Eija Kalso, Jussi Virkkala , et al. · 2023

Introduction Chronic pain associates with various sleep problems. Patients with complex regional pain syndrome (CRPS) often report impaired sleep, but objective measurements of sleep in CRPS patients are scarce. Neuromodulation with repeti…

Pain-related and psychological factors mediate the effect of personality on health-related quality of life. A study in breast cancer survivors with persistent pain Open

Tommi Aho, Hanna Harno, Jari Lipsanen, Eija Kalso, Reetta Sipilä · 2023

Introduction Personality characteristics affect the long-term well-being and health-related quality of life (HrQoL) of breast cancer (BC) survivors. Persistent pain significantly affects psychosocial well-being and HrQoL in this patient gr…

Repetitive transcranial magnetic stimulation (rTMS) for complex regional pain syndrome (CRPS) Open

Edlira Mulo, Juhani Ojala, Hanna Harno, Janne Nordberg, Teijo I. Saari , et al. · 2023

Background: Complex regional pain syndrome (CRPS) is a chronic pain condition occurring after trauma, even minor injuries. CRPS can be difficult to diagnose and treat, and its pathophysiology is incompletely understood. Diagnosis of CRPS i…

Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation Open

Jörn Lötsch, Laura Mustonen, Hanna Harno, Eija Kalso · 2022

Background: Persistent postsurgical neuropathic pain (PPSNP) can occur after intraoperative damage to somatosensory nerves, with a prevalence of 29–57% in breast cancer surgery. Proteomics is an active research field in neuropathic pain an…

Post-traumatic headache after mild traumatic brain injury in a one-year follow up study – risk factors and return to work Open

Yvonn Kraemer, Kaisa Mäki, Ivan Marinković, Taina Nybo, Harri Isokuortti , et al. · 2022

Post-Traumatic Headache After Mild Traumatic Brain Injury In A One-Year Follow Up Study – Risk Factors And Return To Work Open

Yvonn Kraemer, Kaisa Mäki, Ivan Marinković, Taina Nybo, Harri Isokuortti , et al. · 2021

Background: Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Patients at risk to develop acute PTH (aPTH) and further persistent PTH (pPTH) need to be recognized. Methods: This is a one-year f…

A Randomized, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial Open

Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto , et al. · 2021

Breast reconstruction after breast cancer surgery – persistent pain and quality of life 1–8 years after breast reconstruction Open

Nina Honkanen, Laura Mustonen, Eija Kalso, Tuomo J Meretoja, Hanna Harno · 2021

Objectives To assess the long-term outcome of breast reconstructions with special focus on chronic postsurgical pain (CPSP) in a larger cohort of breast cancer survivors. Methods A cross-sectional study on 121 women with mastectomy and bre…

Project DyAdd: Non-linguistic Theories of Dyslexia Predict Intelligence Open

Marja Laasonen, Pekka Lahti‐Nuuttila, Sami Leppämäki, Pekka Tani, Jan Wikgren , et al. · 2020

Two themes have puzzled the research on developmental and learning disorders for decades. First, some of the risk and protective factors behind developmental challenges are suggested to be shared and some are suggested to be specific for a…

Static mechanical allodynia in post-surgical neuropathic pain after breast cancer treatments Open

Laura Mustonen, Tommi Aho, Hanna Harno, Eija Kalso · 2020

Objectives Static mechanical allodynia (SMA), i. e., pain caused by normally non-painful static pressure, is a prevalent manifestation of neuropathic pain (NP). Although SMA may significantly affect the patient’s daily life, it is less wel…

Sensory profiles in women with neuropathic pain after breast cancer surgery Open

Laura Mustonen, Jan Vollert, Alexandra Rice, Eija Kalso, Hanna Harno · 2020

Psychological resilience associates with pain experience in women treated for breast cancer Open

Sanna Liesto, Reetta Sipilä, Tommi Aho, Hanna Harno, Marja Hietanen , et al. · 2020

Background and aims Psychological resilience refers to successful adaptation or a positive outcome in the context of significant life adversity, such as chronic pain. On the other hand, anxiety closely associates with pain. The aim of this…

Douleur Neuropathique 4 (DN4) stratifies possible and definite neuropathic pain after surgical peripheral nerve lesion Open

Tommi Aho, Laura Mustonen, Eija Kalso, Hanna Harno · 2019

Background Douleur Neuropathique 4 (DN4) is a screening questionnaire to help identify neuropathic pain (NP) in clinical practice and research. We tested the accuracy of the DN4 questionnaire in stratifying possible NP (pNP) and definite N…

Symptom reduction and improved function in chronic CRPS type 1 after 12-week integrated, interdisciplinary therapy Open

Minna M. Elomaa, Jaakko Hotta, Amanda C de C Williams, Nina Forss, Anni Äyräpää , et al. · 2019

Background and aims Complex Regional Pain Syndrome (CRPS) often recovers spontaneously within the first year, but when it becomes chronic, available rehabilitative therapies (pharmacological management, physiotherapy, and psychological int…

From Tertiary to Primary Care – Understanding Context in the Transfer of Digital Headache Service Pathway Open

Auri Väljä, Henni Tenhunen, Hanna Harno, Laura Mäkitie, Tuomo Tanila , et al. · 2019

A digital service pathway for managing chronic headache has been designed in tertiary care in Finland. The digital tool facilitates self-management by providing exercises, information and messaging opportunities for patients. However, the …

What makes surgical nerve injury painful? A 4-year to 9-year follow-up of patients with intercostobrachial nerve resection in women treated for breast cancer Open

Laura Mustonen, Tommi Aho, Hanna Harno, Reetta Sipilä, Tuomo J Meretoja , et al. · 2018

Nerve injury during breast cancer surgery can cause neuropathic pain (NP). It is not known why some, but not all, patients develop chronic postsurgical neuropathic pain (CPSNP) after the same nerve injury. In this study, we examined 251 br…

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families Open

Padhraig Gormley, Mitja Kurki, Marjo Hiekkala, Kumar Veerapen, Paavo Häppölä , et al. · 2018

Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families Open

Padhraig Gormley, Mitja Kurki, Marjo Hiekkala, Kumar Veerapen, Paavo Häppölä , et al. · 2018

The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families Open

Marjo Hiekkala, Pietari Vuola, Ville Artto, Paavo Häppölä, Elisa Häppölä , et al. · 2018

Objective To study the position of hemiplegic migraine in the clinical spectrum of migraine with aura and to reveal the importance of CACNA1A, ATP1A2 and SCN1A in the development of hemiplegic migraine in Finnish migraine families. Methods…

Sfenopalatiiniganglion stimulaatio - kroonisen sarjoittaisen päänsäryn uusi hoitomuoto Open

Hanna Harno, Liisa Tomppo, Ville Artto, Tommy Wilkman, Karri Mesimäki , et al. · 2018

Monimuotoisen alueellisen kipuoireyhtymän syntymekanismit Open

Elena Haapaniemi, Jaakko Hotta, Hanna Harno · 2018

Common variant burden contributes significantly to the familial aggregation of migraine in 1,589 families Open

Padhraig Gormley, Mitja Kurki, Marjo Hiekkala, Kumar Veerapen, Paavo Häppölä , et al. · 2017

It has long been observed that complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. Two competing hypotheses exist, emphasizing either rare or common g…

Complex regional pain syndrome: The matter of white matter? Open

Jaakko Hotta, Guangyu Zhou, Hanna Harno, Nina Forss, Riitta Hari · 2017

Introduction Many central pathophysiological aspects of complex regional pain syndrome ( CRPS ) are still unknown. Although brain‐imaging studies are increasingly supporting the contribution of the central nervous system to the generation …

Transkraniaalinen magneettistimulaatio neuropaattisen kivun hoidossa Open

Nora Hagelberg, Hanna Harno, Maija Saijonkari, Jaana Isojärvi, Marjut Mäkelä , et al. · 2017

Long-term safety and efficacy of teriflunomide Open

Paul O’Connor, Cristoforo Comi, Mark S. Freedman, Aaron Miller, Ludwig Kappos , et al. · 2016

This study provides Class III evidence that long-term treatment with teriflunomide is well-tolerated and efficacy of teriflunomide is maintained long-term.

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