Hanna‐Mari Baldauf
YOU?
Author Swipe
View article: Deciphering the origins of guanylate-binding proteins in mammals (Monotreme, Marsupials and Placentals)
Deciphering the origins of guanylate-binding proteins in mammals (Monotreme, Marsupials and Placentals) Open
Background Guanylate-binding proteins (GBPs) belong to the large guanosine triphosphatases (GTPases) family and have specialised in host defence in vivo against a broad spectrum of invading pathogens. This ancient evolutionary group of gen…
View article: Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions
Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions Open
Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases, and their expression can be partially induced by interferon…
View article: Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5
Ten rapid antigen tests for SARS-CoV-2 widely differ in their ability to detect Omicron-BA.4 and -BA.5 Open
View article: Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages
Automated antigen assays display a high heterogeneity for the detection of SARS-CoV-2 variants of concern, including several Omicron sublineages Open
Diagnostic tests for direct pathogen detection have been instrumental to contain the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) pandemic. Automated, quantitative, laboratory-based nucleocapsid antigen (Ag) tests for …
View article: Evolution of primate interferon-induced transmembrane proteins (IFITMs): a story of gain and loss with a differentiation into a canonical cluster and IFITM retrogenes
Evolution of primate interferon-induced transmembrane proteins (IFITMs): a story of gain and loss with a differentiation into a canonical cluster and IFITM retrogenes Open
Interferon-inducible transmembrane proteins (IFITMs) are a family of transmembrane proteins. The subgroup of immunity-related (IR-)IFITMs is involved in adaptive and innate immune responses, being especially active against viruses. Here, w…
View article: Inhibition of Infectious HIV-1 Production by Rerouting the Cellular Furin Inhibitor Serpin B8
Inhibition of Infectious HIV-1 Production by Rerouting the Cellular Furin Inhibitor Serpin B8 Open
Many cellular proteases serve as dependency factors during viral infection and are hijacked by viruses for the maturation of their own (glyco)proteins. Consequently, inhibition of these cellular proteases may represent a means to inhibit t…
View article: Editorial on special issue on “Immunobiology of Viral Infections”
Editorial on special issue on “Immunobiology of Viral Infections” Open
View article: Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests
Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests Open
View article: HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo
HIV-1 Infection of Long-Lived Hematopoietic Precursors In Vitro and In Vivo Open
Latent reservoirs in human-immunodeficiency-virus-1 (HIV-1)-infected individuals represent a major obstacle in finding a cure for HIV-1. Hematopoietic stem and progenitor cells (HSPCs) have been described as potential HIV-1 targets, but th…
View article: Functional cross-species conservation of guanylate-binding proteins in innate immunity
Functional cross-species conservation of guanylate-binding proteins in innate immunity Open
View article: Impaired detection of omicron by SARS-CoV-2 rapid antigen tests
Impaired detection of omicron by SARS-CoV-2 rapid antigen tests Open
View article: Evolution of Guanylate Binding Protein (GBP) Genes in Muroid Rodents (Muridae and Cricetidae) Reveals an Outstanding Pattern of Gain and Loss
Evolution of Guanylate Binding Protein (GBP) Genes in Muroid Rodents (Muridae and Cricetidae) Reveals an Outstanding Pattern of Gain and Loss Open
Guanylate binding proteins (GBPs) are paramount in the host immunity by providing defense against invading pathogens. Multigene families related to the immune system usually show that the duplicated genes can either undergo deletion, gain …
View article: Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SA…
View article: P01.04 Lentiviral protein Vpx delivery systems as potential weapons to improve cytarabine treatment response against acute myeloid leukemia
P01.04 Lentiviral protein Vpx delivery systems as potential weapons to improve cytarabine treatment response against acute myeloid leukemia Open
Background Acute myeloid leukemia (AML) is an aggressive cancer of the blood, where malignant myeloid blasts accumulate in the bone marrow. One of the challenges of effective AML treatment is resistance to cytarabine (or ara-C), a standard…
View article: Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern
Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern Open
View article: Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Summary Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. H…
View article: Evaluation of a Configurable, Mobile and Modular Floor-Pen System for Group-Housing of Laboratory Rabbits
Evaluation of a Configurable, Mobile and Modular Floor-Pen System for Group-Housing of Laboratory Rabbits Open
The major responsibility of researchers and laboratory animal facilities is to ensure animal well-being during the time of acclimatization, experiments, and recovery. In this context, animal housing conditions are of utmost importance. Her…
View article: Thermal Inactivation of Carcasses of Mice and Rabbits Infected with Pathogens of Risk Groups Two to Four
Thermal Inactivation of Carcasses of Mice and Rabbits Infected with Pathogens of Risk Groups Two to Four Open
Pathogenesis of viruses or other agents that are infectious to humans is frequently studied in vivo using natural or genetically modified animals. Depending on the risk group of the pathogen, the majority of such experimental studies are p…
View article: Additional file 15 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Additional file 15 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Additional file 15: Supplementary Table 6. Concentrations that reduce the cell viability by 50% (IC50 values), determined by MTT assay after 96 h incubation.
View article: Additional file 13 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells
Additional file 13 of Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells Open
Additional file 13: Supplementary Table 4. Characteristics of AML patients analysed in the data presented in Fig. 3.
View article: The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists
The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists Open
A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. …
View article: Rabbits as a model to study HIV-1 infection and the search for new innate immunity players in resting CD4 T cells
Rabbits as a model to study HIV-1 infection and the search for new innate immunity players in resting CD4 T cells Open
Once infected with human immunodeficiency virus (HIV), currently available pharmacotherapies can only partly control, but not cure infection. Thus, there remains an urgent need for more potent and conceptually novel antiviral therapeutics,…
View article: Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia
Correction: Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia Open
View article: Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy Patients
Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy Patients Open
Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations in the AIRE gene. Although mainly an endocrine disease, a substantial fraction of patients have gastrointestinal …
View article: Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells
Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells Open
DCs express intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. Thus, DCs are productively infected only at very low levels with HIV-1, and this non-permissiveness of DCs is suggested to go along with viral eva…